DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zpr1 and ZPR1

DIOPT Version :9

Sequence 1:	NP_572532.1	Gene:	Zpr1 / 31851	FlyBaseID:	FBgn0030096	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_011727.3	Gene:	ZPR1 / 853125	SGDID:	S000003443	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	483	Identity:	192/483 - (39%)
Similarity:	284/483 - (58%)	Gaps:	55/483 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ESAGNIRPEPIFREINAEQTDEIV-----------EVESACMNCFETGVTRLLPTKIPFFREVVL 67
            |:|..:..|.|..:..|....::.           |:||.||||.:.|.||||.|.||:|||:::
Yeast    14 EAAAEVEDESIAEQNKANDGVKLTGAQDAMGHPVQEIESLCMNCGKNGTTRLLLTSIPYFREIII 78

  Fly    68 MSFKCDHCGHINNEMQSASEIQKSGIRIELRVQSVADLNRRVVRSDNSSISIPEIELEIPVQSQK 132
            |||.|.|||..|.|:|.||:||:.|.|..|:|:...|.||:|::|:.::....|:::|||  :::
Yeast    79 MSFDCPHCGFKNCEIQPASQIQEKGSRYVLKVECREDFNRQVIKSETATCKFVELDIEIP--AKR 141

  Fly   133 GEVTTVEGIIERTIAGLSQDQEKRRIDHPETAASIEKYIERLH---RLKEVTTPFQVLLEDISGN 194
            |::|||||::...|..||||||.|:.........|:.:|:::.   ..:..|.|...:|:|.:||
Yeast   142 GQLTTVEGLLSEMIDDLSQDQEMRKSIDEALYKKIDDFIQKVKSYINCEPNTIPITFILDDPAGN 206

  Fly   195 SFIE-NPLAPAADPQLKTSY--FTRSQQQNEQLGL-----YEQNHEEQHLLKPIA---------- 241
            |:|| .|    .:||.|.|:  :.|:.:||.|:|:     .||..:||  ||.:|
Yeast   207 SWIEYKP----GEPQHKWSHTQYVRTDEQNVQVGIITRDQLEQRRQEQ--LKQLANRERNPSESV 265

  Fly   242 ----------EDSWPIENLHGEVLQFPTNCPSCQAPCETNMKLTNIPHFKEVVIMATVCGACGHK 296
                      .|:..|||.:.||..|..:||||...|||:||..||||||||:||:|||..||:|
Yeast   266 KVGSANPQFLSDATDIENFNNEVQTFRASCPSCTQECETHMKPVNIPHFKEVIIMSTVCDHCGYK 330

  Fly   297 TNEVKSGGGVEAQGVRFRVQIASREDLTRDVLKSETCSMSIPELDLEVGPHALCGRFTTVEGLLV 361
            :||||:||.:..:|.|..:......||:||:||||||||.||||.|::....|.|||||:||||.
Yeast   331 SNEVKTGGAIPDKGRRITLYCDDAADLSRDILKSETCSMVIPELHLDIQEGTLGGRFTTLEGLLR 395

  Fly   362 AMRDQLDGTLF---HDSADDATKQQMQRFLDTFEDVMNLKRVITLVLEDPAGNTYVQSLSDDDSE 423
            .:.::|:..:|   .||.|:|||.:...|....::.:..|...|:::|||...:|:|::...|
Yeast   396 QVYEELESRIFTQTSDSMDEATKARWVEFFAKLKEAIAGKVKFTVIMEDPLAGSYIQNVYAPD-- 458

  Fly   424 PDDKLTVERYDRSYEDNEDLGLNDMKTE 451
            ||..:|:|.|:|:.|.||||||:|:|.|
Yeast   459 PDPNMTIEDYERTKEQNEDLGLSDIKVE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zpr1	NP_572532.1	Zpr1	41..199	CDD:128949	68/161 (42%)
Zpr1	NP_572532.1	Zpr1	259..416	CDD:128949	75/159 (47%)
ZPR1	NP_011727.3	zf-ZPR1	52..210	CDD:397443	66/159 (42%)
ZPR1	NP_011727.3	ZPR1_znf	293..486	CDD:273007	92/194 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346333
Domainoid	1	1.000	155	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E1_COG1779
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2900
Inparanoid	1	1.050	332	1.000	Inparanoid score	I421
Isobase	1	0.950	-	0	Normalized mean entropy	S680
OMA	1	1.010	-	-		QHG54073
OrthoFinder	1	1.000	-	-		FOG0004365
OrthoInspector	1	1.000	-	-		oto100124
orthoMCL	1	0.900	-	-		OOG6_101443
Panther	1	1.100	-	-	LDO	PTHR10876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2015
SonicParanoid	1	1.000	-	-		X3087
TreeFam	1	0.960	-	-
	16	15.740