DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zpr1 and zpr1

DIOPT Version :9

Sequence 1:	NP_572532.1	Gene:	Zpr1 / 31851	FlyBaseID:	FBgn0030096	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_998273.1	Gene:	zpr1 / 406382	ZFINID:	ZDB-GENE-040426-2110	Length:	441	Species:	Danio rerio

Alignment Length:	440	Identity:	213/440 - (48%)
Similarity:	301/440 - (68%)	Gaps:	18/440 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IFREINAEQTD-EIVEVESACMNCFETGVTRLLPTKIPFFREVVLMSFKCDHCGHINNEMQSASE 87
            :|::||||..| :...:||.||||:|.|.||||.||||||:|:::.||.|.||...|.|:|||..
Zfish    13 VFKDINAEDEDQQPTVIESLCMNCYENGSTRLLLTKIPFFKEIIISSFACPHCNWSNTEIQSAGR 77

  Fly    88 IQKSGIRIELRVQSVADLNRRVVRSDNSSISIPEIELEIPVQSQKGEVTTVEGIIERTIAGLSQD 152
            ||:.|::..|:|::..|:||.||:||::|..||:::.|||..:|||.::|:||:::|.:|||.||
Zfish    78 IQEQGVQYTLQVKTKRDMNREVVKSDSASTRIPQLDFEIPAFTQKGSLSTIEGLLDRAVAGLEQD 142

  Fly   153 QEKRRIDHPETAASIEKYIERLHRLKEVTTPFQVLLEDISGNSFIENPLAPAADPQLKTSYFTRS 217
            |..|:...|..|..||::|:||.:||||...|.::::|.|||||||||.||..|..|..:|:.|:
Zfish   143 QPIRKATDPTVADKIEEFIQRLKKLKEVEDEFSLIIDDPSGNSFIENPFAPQKDAALSVTYYKRT 207

  Fly   218 QQQNEQLGLYEQNHEEQHLLKPIAEDSWP---IENLHGEVLQFPTNCPSCQAPCETNMKLTNIPH 279
            .|||..||:  :..|||      |::| |   ::.|..|||.|.||||.|.||..|||||..|||
Zfish   208 PQQNAALGI--EVEEEQ------ADES-PGNDLDTLRNEVLVFNTNCPECNAPANTNMKLVQIPH 263

  Fly   280 FKEVVIMATVCGACGHKTNEVKSGGGVEAQGVRFRVQIASREDLTRDVLKSETCSMSIPELDLEV 344
            ||||:||||.|.:|||:||||||||..|..|.|..:.:....|::||:|||||||:.||||:.|:
Zfish   264 FKEVIIMATNCDSCGHRTNEVKSGGATEELGTRITLHLTDPSDMSRDLLKSETCSVLIPELEFEL 328

  Fly   345 GPHALCGRFTTVEGLLVAMRDQL---DGTLFHDSADDATKQQMQRFLDTFEDVMNLKRVITLVLE 406
            |..||.|:||||||||..:::.:   :..:..||:.....:::|.|....:.:|..:..:.:||:
Zfish   329 GMAALGGKFTTVEGLLKDIKELIVSKNPFMCGDSSASDRVEKLQLFGQKIDKIMAGEMDVHIVLD 393

  Fly   407 DPAGNTYVQSLSDDDSEPDDKLTVERYDRSYEDNEDLGLNDMKTEGYEEK 456
            |||||:|:|::...|  ||.::.:|:|.|::|.||||||||||||||.||
Zfish   394 DPAGNSYLQNVYAPD--PDPEMKIEKYTRTFEQNEDLGLNDMKTEGYAEK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zpr1	NP_572532.1	Zpr1	41..199	CDD:128949	79/157 (50%)
Zpr1	NP_572532.1	Zpr1	259..416	CDD:128949	78/159 (49%)
zpr1	NP_998273.1	zf-ZPR1	31..188	CDD:281375	78/156 (50%)
zpr1	NP_998273.1	zf-ZPR1	243..402	CDD:281375	78/158 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595454
Domainoid	1	1.000	175	1.000	Domainoid score	I3610
eggNOG	1	0.900	-	-		E1_COG1779
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2900
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1784
OMA	1	1.010	-	-		QHG54073
OrthoDB	1	1.010	-	-		D250130at33208
OrthoFinder	1	1.000	-	-		FOG0004365
OrthoInspector	1	1.000	-	-		oto39668
orthoMCL	1	0.900	-	-		OOG6_101443
Panther	1	1.100	-	-	LDO	PTHR10876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2015
SonicParanoid	1	1.000	-	-		X3087
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800