DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zpr1 and Zpr1

DIOPT Version :9

Sequence 1:	NP_572532.1	Gene:	Zpr1 / 31851	FlyBaseID:	FBgn0030096	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_035882.1	Gene:	Zpr1 / 22687	MGIID:	1330262	Length:	459	Species:	Mus musculus

Alignment Length:	453	Identity:	219/453 - (48%)
Similarity:	299/453 - (66%)	Gaps:	17/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PNSSNPPESAGNIRPE--PIFREINAE-QTDEIVEVESACMNCFETGVTRLLPTKIPFFREVVLM 68
            |.::..|..|....|.  |:||.::|| :..:..|:||.||||:..|.||||.||||||||:::.
Mouse    12 PGAAVGPSPAAAASPATGPLFRPLSAEDEEQQPTEIESLCMNCYRNGTTRLLLTKIPFFREIIVS 76

  Fly    69 SFKCDHCGHINNEMQSASEIQKSGIRIELRVQSVADLNRRVVRSDNSSISIPEIELEIPVQSQKG 133
            ||.|:|||..|.|:|||..||..|:|..|.|:|..|:||.||::|:::..|||::.|||..||||
Mouse    77 SFSCEHCGWNNTEIQSAGRIQDQGVRYTLTVRSQEDMNREVVKTDSATTRIPELDFEIPAFSQKG 141

  Fly   134 EVTTVEGIIERTIAGLSQDQEKRRIDHPETAASIEKYIERLHRLKEVTTPFQVLLEDISGNSFIE 198
            .:|||||:|.|.|:||.|||..||......|..|:::|.:|..||::.:||.::::|.|||||:|
Mouse   142 ALTTVEGLISRAISGLEQDQPTRRAVEGAIAERIDEFIGKLKDLKQMASPFTLVIDDPSGNSFVE 206

  Fly   199 NPLAPAADPQLKTSYFTRSQQQNEQLGLYEQNHEEQHLLKPIAEDSWPIENLHGEVLQFPTNCPS 263
            ||.||..|..|..:|:.|:.||.|.|||..:..||:      ||:    |:|..|||||.||||.
Mouse   207 NPHAPQKDNALVITYYDRTPQQAEMLGLQAEAPEEK------AEE----EDLRNEVLQFNTNCPE 261

  Fly   264 CQAPCETNMKLTNIPHFKEVVIMATVCGACGHKTNEVKSGGGVEAQGVRFRVQIASREDLTRDVL 328
            |.||.:|||||..|||||||:||||.|..|||:||||||||.||..|.|..:.|....|:|||:|
Mouse   262 CNAPAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDPSDMTRDLL 326

  Fly   329 KSETCSMSIPELDLEVGPHALCGRFTTVEGLLVAMRDQLDGTLF--HDSADDATKQQMQRFLDTF 391
            ||||||:.||||:.|:|...|.|:|||:||||..:|:.:....|  .||::....:::|.|....
Mouse   327 KSETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPDQSEKLQEFSQKL 391

  Fly   392 EDVMNLKRVITLVLEDPAGNTYVQSLSDDDSEPDDKLTVERYDRSYEDNEDLGLNDMKTEGYE 454
            ..::..|.....::.|||||:|:|::...:.:|:.|  ||||.|:::.||:||||||||||||
Mouse   392 GQIIEGKMKAHFIMNDPAGNSYLQNVYAPEDDPEMK--VERYKRTFDQNEELGLNDMKTEGYE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zpr1	NP_572532.1	Zpr1	41..199	CDD:128949	81/157 (52%)
Zpr1	NP_572532.1	Zpr1	259..416	CDD:128949	79/158 (50%)
Zpr1	NP_035882.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		9/33 (27%)
		zf-ZPR1	49..206	CDD:281375	81/156 (52%)
		Zpr1	257..416	CDD:128949	81/160 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..459		13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849685
Domainoid	1	1.000	173	1.000	Domainoid score	I3690
eggNOG	1	0.900	-	-		E1_COG1779
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2900
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1781
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54073
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004365
OrthoInspector	1	1.000	-	-		oto94757
orthoMCL	1	0.900	-	-		OOG6_101443
Panther	1	1.100	-	-	LDO	PTHR10876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3087
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760