DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ost48 and ddost

DIOPT Version :9

Sequence 1:	NP_511096.2	Gene:	Ost48 / 31849	FlyBaseID:	FBgn0014868	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_998258.1	Gene:	ddost / 406408	ZFINID:	ZDB-GENE-040426-2147	Length:	441	Species:	Danio rerio

Alignment Length:	434	Identity:	270/434 - (62%)
Similarity:	327/434 - (75%)	Gaps:	8/434 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KALLIAVLAIAHCQAVLETDANTLVLLDNLAIRETHSIFFKSLQDRGFKLTYKLADDSSLLLSKY 68
            |..|..:.|....|||| .|..|||||||..||:||||||:||.||||.||:|.|||..|.|.||
Zfish    11 KNALFILSAALMLQAVL-GDGKTLVLLDNPNIRDTHSIFFRSLADRGFDLTFKTADDPGLSLLKY 74

  Fly    69 GEYLYKNVIIFAPSVEEFGGDVSVERLAQFVDDGGNVLVAGSEKSGDALREFASECGFELDEENA 133
            |::||.::|:|:||||:|||:::||.:..|:|.|||||||.|...||.|||..||||.|.|||..
Zfish    75 GQFLYDHLILFSPSVEDFGGNINVETITAFIDGGGNVLVAASSDIGDPLRELGSECGIEFDEEKT 139

  Fly   134 AVIDHLHYDVSDAGEHTTILTSAKNLIQADTIVGKANRQADAAPLLYRGTGLIADKENPLVLKLL 198
            |||||.:||:||.||||.|:...:||::|.|||||...:    |:|::|.|::||.:|||||.:|
Zfish   140 AVIDHHNYDISDPGEHTLIVADPENLLKAPTIVGKPTDK----PVLFKGVGMVADPDNPLVLDIL 200

  Fly   199 TAESTAYSYNPEASVSDYPHAVGRGTLLIAALQARNNARVVFSGSLLFFSDESFTTAVQYAQSG- 262
            |..||:|||.|:..::.||||||:.|||||.|||||||||||||||.||||..|.:|||.|.:|
Zfish   201 TGSSTSYSYFPDRPITQYPHAVGKNTLLIAGLQARNNARVVFSGSLHFFSDAFFNSAVQKAATGS 265

  Fly   263 VFHKLAGNRDVAESISKWVFGETGRLRVASVQHHKEGELLPPDQAYTITDPVVYTIGIEELVQGE 327
            ..::..||:|:||::|:|||.|.|.|||..|.||..||..|| .|||:||.|.|.|.||.|..|:
Zfish   266 KRYEQTGNQDLAEALSRWVFKEAGVLRVGDVTHHPVGESTPP-AAYTVTDLVEYGIVIEMLSGGK 329

  Fly   328 WRAFKASDIQLEFVRIDPFVRTYLKQTNTGAYQAKFKIPDVYGVYQFKVDYNRVGYTHLYSTTQV 392
            |..|...||||||||||||||||||: |.|.|..:||:||||||:||||||||:|||||||:|||
Zfish   330 WVPFDGDDIQLEFVRIDPFVRTYLKK-NGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQV 393

  Fly   393 SVRPLEHTQYERFIPSAFPYYTSAFSMMIGVFVFSFVFLHFKDE 436
            |||||:|||||||||||||||.||||||.|:||||.||||.:::
Zfish   394 SVRPLQHTQYERFIPSAFPYYASAFSMMAGLFVFSVVFLHMREK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ost48	NP_511096.2	DDOST_48kD	27..437	CDD:281356	261/411 (64%)
ddost	NP_998258.1	DDOST_48kD	33..440	CDD:281356	261/411 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596029
Domainoid	1	1.000	520	1.000	Domainoid score	I291
eggNOG	1	0.900	-	-		E1_KOG2754
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3821
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1208
OMA	1	1.010	-	-		QHG54376
OrthoDB	1	1.010	-	-		D308610at33208
OrthoFinder	1	1.000	-	-		FOG0004192
OrthoInspector	1	1.000	-	-		oto40241
orthoMCL	1	0.900	-	-		OOG6_103031
Panther	1	1.100	-	-	LDO	PTHR10830
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R878
SonicParanoid	1	1.000	-	-		X2938
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840