DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ost48 and DDOST

DIOPT Version :9

Sequence 1:	NP_511096.2	Gene:	Ost48 / 31849	FlyBaseID:	FBgn0014868	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_005207.3	Gene:	DDOST / 1650	HGNCID:	2728	Length:	439	Species:	Homo sapiens

Alignment Length:	437	Identity:	263/437 - (60%)
Similarity:	334/437 - (76%)	Gaps:	14/437 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMWKALLIAVLAIAHCQAVLETDANTLVLLDNLAIRETHSIFFKSLQDRGFKLTYKLADDSSLLL 65
            :.|  ||:.:|.     ||..:...||||||||.:|||||:||:||:||||:||:|.|||.||.|
Human    12 LFW--LLLPLLG-----AVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSL 69

  Fly    66 SKYGEYLYKNVIIFAPSVEEFGGDVSVERLAQFVDDGGNVLVAGSEKSGDALREFASECGFELDE 130
            .||||:||.|:|||:||||:|||:::||.::.|:|.||:||||.|...||.|||..||||.|.||
Human    70 IKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDE 134

  Fly   131 ENAAVIDHLHYDVSDAGEHTTILTSAKNLIQADTIVGKANRQADAAPLLYRGTGLIADKENPLVL 195
            |..|||||.:||:||.|:||.|:...:||::|.|||||::..    |:|:||.|::||.:|||||
Human   135 EKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLN----PILFRGVGMVADPDNPLVL 195

  Fly   196 KLLTAESTAYSYNPEASVSDYPHAVGRGTLLIAALQARNNARVVFSGSLLFFSDESFTTAVQYAQ 260
            .:||..||:||:.|:..::.||||||:.|||||.|||||||||:|||||.||||..|.:|||.|.
Human   196 DILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAA 260

  Fly   261 SG-VFHKLAGNRDVAESISKWVFGETGRLRVASVQHHKEGELLPPDQAYTITDPVVYTIGIEELV 324
            .| ..:...||.::|.::|:|||.|.|.|||..|.||:.||..||: |||:||.|.|:|.|::|.
Human   261 PGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN-AYTVTDLVEYSIVIQQLS 324

  Fly   325 QGEWRAFKASDIQLEFVRIDPFVRTYLKQTNTGAYQAKFKIPDVYGVYQFKVDYNRVGYTHLYST 389
            .|:|..|...|||||||||||||||:||:.. |.|..:||:||||||:||||||||:|||||||:
Human   325 NGKWVPFDGDDIQLEFVRIDPFVRTFLKKKG-GKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSS 388

  Fly   390 TQVSVRPLEHTQYERFIPSAFPYYTSAFSMMIGVFVFSFVFLHFKDE 436
            ||||||||:|||||||||||:|||.||||||:|:|:||.||||.|::
Human   389 TQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ost48	NP_511096.2	DDOST_48kD	27..437	CDD:281356	256/411 (62%)
DDOST	NP_005207.3	DDOST_48kD	30..438	CDD:367455	257/412 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159792
Domainoid	1	1.000	524	1.000	Domainoid score	I298
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3821
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54376
OrthoDB	1	1.010	-	-		D308610at33208
OrthoFinder	1	1.000	-	-		FOG0004192
OrthoInspector	1	1.000	-	-		oto89783
orthoMCL	1	0.900	-	-		OOG6_103031
Panther	1	1.100	-	-	LDO	PTHR10830
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R878
SonicParanoid	1	1.000	-	-		X2938
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940