DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ost48 and Ddost

DIOPT Version :9

Sequence 1:	NP_511096.2	Gene:	Ost48 / 31849	FlyBaseID:	FBgn0014868	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_031864.2	Gene:	Ddost / 13200	MGIID:	1194508	Length:	441	Species:	Mus musculus

Alignment Length:	432	Identity:	265/432 - (61%)
Similarity:	332/432 - (76%)	Gaps:	12/432 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAVLAIAHCQAVLETDANTLVLLDNLAIRETHSIFFKSLQDRGFKLTYKLADDSSLLLSKYGE 70
            ||:|||.     .|..:...||||||||.:|:|||:||:||:||||:||:|.|||.||.|.||||
Mouse    17 LLLAVLG-----CVCASGPRTLVLLDNLNVRDTHSLFFRSLKDRGFELTFKTADDPSLSLIKYGE 76

  Fly    71 YLYKNVIIFAPSVEEFGGDVSVERLAQFVDDGGNVLVAGSEKSGDALREFASECGFELDEENAAV 135
            :||.|:|||:||||:|||:::||.::.|:|.||:||||.|...||.|||..||||.|.|||..||
Mouse    77 FLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAV 141

  Fly   136 IDHLHYDVSDAGEHTTILTSAKNLIQADTIVGKANRQADAAPLLYRGTGLIADKENPLVLKLLTA 200
            |||.:|||||.|:||.|:...:||::|.|||||::..    |:|:||.|::||.:|||||.:||.
Mouse   142 IDHHNYDVSDLGQHTLIVADTENLLKAPTIVGKSSLN----PILFRGVGMVADPDNPLVLDILTG 202

  Fly   201 ESTAYSYNPEASVSDYPHAVGRGTLLIAALQARNNARVVFSGSLLFFSDESFTTAVQYAQSGV-F 264
            .||:||:.|:..::.|||||||.|||||.|||||||||:|||||.||||..|.:|||.|..|. .
Mouse   203 SSTSYSFFPDKPITQYPHAVGRNTLLIAGLQARNNARVIFSGSLDFFSDAFFNSAVQKATPGAQR 267

  Fly   265 HKLAGNRDVAESISKWVFGETGRLRVASVQHHKEGELLPPDQAYTITDPVVYTIGIEELVQGEWR 329
            :...||.::|.::|:|||.|.|.|||..|.||:.||:.||: |||:||.|.|:|.||:|..|:|.
Mouse   268 YSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGEMAPPN-AYTVTDLVEYSIIIEQLSNGKWV 331

  Fly   330 AFKASDIQLEFVRIDPFVRTYLKQTNTGAYQAKFKIPDVYGVYQFKVDYNRVGYTHLYSTTQVSV 394
            .|...|||||||||||||||:||:.. |.|..:||:||||||:||||||||:|||||||:|||||
Mouse   332 PFDGDDIQLEFVRIDPFVRTFLKRKG-GKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSV 395

  Fly   395 RPLEHTQYERFIPSAFPYYTSAFSMMIGVFVFSFVFLHFKDE 436
            |||:|||||||||||:|||.||||||.|:|:||.||||.|::
Mouse   396 RPLQHTQYERFIPSAYPYYASAFSMMAGLFIFSIVFLHMKEK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ost48	NP_511096.2	DDOST_48kD	27..437	CDD:281356	258/411 (63%)
Ddost	NP_031864.2	DDOST_48kD	33..440	CDD:281356	258/411 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850162
Domainoid	1	1.000	525	1.000	Domainoid score	I298
eggNOG	1	0.900	-	-		E1_KOG2754
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3821
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1216
Isobase	1	0.950	-	0	Normalized mean entropy	S1467
OMA	1	1.010	-	-		QHG54376
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004192
OrthoInspector	1	1.000	-	-		oto93355
orthoMCL	1	0.900	-	-		OOG6_103031
Panther	1	1.100	-	-	LDO	PTHR10830
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R878
SonicParanoid	1	1.000	-	-		X2938
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740