Protein Alignment AP-1gamma and AP1G2

DIOPT Version :10

• Sequence 1: NP_788891.2
• Gene: AP-1gamma / 31842
• FlyBaseID: FBgn0030089
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: XP_047287805.1
• Gene: AP1G2 / 8906
• HGNCID: 556
• Length: 876
• Species: Homo sapiens
• Alignment Length: 1006
• Identity: 417/1006 - (41%)
• Similarity: 545/1006 - (54%)
• Gaps: 238/1006 - (23%)

  Fly    39 RVRMPTPT-RLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGY 102
            |.||..|: :|:|||.:||.|:|.|:||.|:.||||:||::||:.|.|.|.|.:|||||:|||||
Human    32 RERMVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGY 96

  Fly   103 PAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTL 167
            ||||||:|||||.||:||||||:||||||||||||.|.||||||.:||||:...|.|.|||||||
Human    97 PAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTL 161

  Fly   168 GAIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNH--- 229
            ..:.|.||.||||.|||:|:..|:.|:||||.|.|..:||:||||..:|||....||.|::|
Human   162 STMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHERHHGKA 226

  Fly   230 ------------------------------------------------------GILITGVTLIT 240
                                                                  |||:..:||||
Human   227 VGPPILCFRSMDRRIENRMGTPAHRRRVVHTHRHTRNRLSCPWPPPFTSPTLTPGILLGTITLIT 291

  Fly   241 EMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLLRILGH 305
            |:||.|...|.||:|      :||.||.||:.|:..|||.||.:||||||||||:|||||||||.
Human   292 ELCERSPAALRHFRK------VVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGR 350

  Fly   306 NDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLNSDKN 370
            |..::||.|||:||||||||:||:|.||.:|:||||:||||||..||||||||||||||||||:|
Human   351 NHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGRFLLNSDRN 415

  Fly   371 IRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTMTKELLLF 435
            ||||||.:|||.|.:|.|||||||.|::|||::.|.|:.|||:|||.||:|:.|:|.|.:||..|
Human   416 IRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLALVNSSNVRAMMQELQAF 480

  Fly   436 LEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQ 500
            ||....:.:|.|:||::|||||::||.|||:||.|.||..||.:||||.|::..||:..:. ...
Human   481 LESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQ-ELH 544

  Fly   501 TYITNRFWESLQVANHCED--KQPLLQVAVWAIGEYGDLFMYGANEDEFE--RPTESDLIAVYYK 561
            .|...|.:.:|     .||  :|||:|||.|.|||||||.:.| |.:|.|  :..|.:::|:..|
Human   545 AYSVRRLYNAL-----AEDISQQPLVQVAAWCIGEYGDLLLAG-NCEEIEPLQVDEEEVLALLEK 603

  Fly   562 FLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKHL 626
            .|.|......::.|||.:|.||||||......|:.:::.:||.|:|:||||.||:..||..|.|:
Human   604 VLQSHMSLPATRGYALTALMKLSTRLCGDNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHM 668

  Fly   627 RPPLLEKMPAMQISRISSQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNIL 691
            |..:|||||.:          |..|...|:.:.:..|
Human   669 RAAILEKMPLV----------ERDGPQADEEAKESKE---------------------------- 695

  Fly   692 LDLLGSTDLSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNN---QDLLDLLDLDLSAPSST 753
                               |..||.|             |||...   ..|||||||
Human   696 -------------------AAQLSEA-------------APVPTEPQASQLLDLLDL-------- 720

  Fly   754 TTGAPAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGL 818
                                                        ||.::             |.:
Human   721 --------------------------------------------LDGAS-------------GDV 728

  Fly   819 GAPPAASPSLAASAPVGNLIDGHAGSLLADLNPTAASNNVVVPPQG--PRLTALDKDGLLVQLVS 881
            ..||...||     |.|.|:.      |.||       ..|.||..  |.|...:::|:.:.|..
Human   729 QHPPHLDPS-----PGGALVH------LLDL-------PCVPPPPAPIPDLKVFEREGVQLNLSF 775

  Fly   882 VRGSD---CMRIYMTTTNNSDNTLDQYLLQAAVQRSFQLQMLTPSGSVLPP-GGV-ITQEMRVVA 941
            :|..:   .:.|.:|.||.|:..:..::.||||.:|.|||:..|||:.:|. ||: |||..|::.
Human   776 IRPPENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILN 840

  Fly   942 TSNATLRMRLRIQYVLDGQQQVEQTEVSGFP 972
            .:.|.||::||:.|....|...|..||:..|
Human   841 PNKAPLRLKLRLTYDHFHQSVQEIFEVNNLP 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:396262	320/616 (52%)
		Alpha_adaptinC2	869..972	CDD:197886	36/107 (34%)
AP1G2	XP_047287805.1	Adaptin_N	58..666	CDD:396262	323/620 (52%)
		Alpha_adaptinC2	763..871	CDD:197886	36/107 (34%)