Protein Alignment AP-1gamma and APL4

DIOPT Version :10

• Sequence 1: NP_788891.2
• Gene: AP-1gamma / 31842
• FlyBaseID: FBgn0030089
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_015354.1
• Gene: APL4 / 856141
• SGDID: S000006233
• Length: 832
• Species: Saccharomyces cerevisiae
• Alignment Length: 972
• Identity: 278/972 - (28%)
• Similarity: 444/972 - (45%)
• Gaps: 213/972 - (21%)

  Fly    48 LRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCR--NIAKLLYIHMLGYPAHFGQLE 110
            ||..|:.:|.|:|.|:|||::.|:.|.||:..|::......|  ||.||||:::||...||||:|
Yeast     5 LRSFIKDVRGAKTLADERAIITKQSAKIRTKLRDDHLPHEKRRVNIQKLLYLYILGEKTHFGQVE 69

  Fly   111 CLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASPEM 175
            .:.|.||..|.|||:|||.|.|||||.:|:..|:||.|.|||:...::.|.|||.:||.::|||:
Yeast    70 SINLIASDDFVDKRLGYLAATLLLDESEDLLTLLTNMLNNDLHHPNKYAVSLALTSLGFLSSPEL 134

  Fly   176 ARDLASEVERLMK-SPNTYIRKKATLCAFRVIRRVPELMEIF-LPATRSLLSEKN---HGILITG 235
            ||||..:||.::| |.:.::.|||..||.::|.:...|:||| :.....:||..:   ||:|: |
Yeast   135 ARDLYPDVENIIKNSRDPFLLKKALQCAAKLIFKDVSLLEIFNIEDITKILSSHSICTHGVLL-G 198

  Fly   236 VTLITEMCENSSDTL--MHFKKDSG--------NREIVPNLVRILK-------NLILGGYSPEHD 283
            ||.|.:     |..|  ::.|||..        :.:|:..|..:|:       |:......|.:|
Yeast   199 VTKIIQ-----SILLIGLNRKKDEDEDEDGIDYSNDILSPLSLLLRDFFIRLENMNSKNIEPGYD 258

  Fly   284 VSGVSDPFLQVKILRLLRIL--------GHNDPDASEAMNDILAQVATNTETSKNVGNTILYETV 340
            |.|:.|||||.:|:..|::.        .:|..|..:...|:|.::||||:::||.|..||||||
Yeast   259 VQGICDPFLQCEIIYTLKLYFQVGELLNSNNVLDYKDNFCDLLTRIATNTDSTKNSGQAILYETV 323

  Fly   341 LSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPD 405
            .:|..:.....||||.:|||.:||...|.|.:||:|||||:.|..:.:||||||..|..||:|.|
Yeast   324 KTIFSLDLNQPLRVLGINILAKFLAGKDNNTKYVSLNTLLKVVPQEPTAVQRHRKFISHCLQDTD 388

  Fly   406 VSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPT--TR----- 463
            ||||.||:|||||:::..|:..:..||:.||.|.|.:.|    ..:|...:....|  ||
Yeast   389 VSIRMRALELSFAILDDSNLVELVNELMKFLAKQDEDSK----DLIIYTIDHLIDTFDTRVVKDE 449

  Fly   464 -WHLDTQLSVLIAAGNYVRDD-------VVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDK 520
             |.||...::|...|:::..:       ::::|.||...|....:....:....|.:::   |:.
Yeast   450 SWKLDVFFNILKLVGSFINYEKINDILIIINNTSQLSDKSEFLRKMLTISLNGTSAEIS---EEN 511

  Fly   521 QPLLQVAVWAIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSK--QYALVSLAKL 583
            .....|.:|.|||||||.:...|::..:...||. |..|...|.....:|..|  .|.|.:..||
Yeast   512 IGWQLVLIWCIGEYGDLVLNEGNKNGADIINESS-ITDYLLTLQELYTATNLKIINYILTAALKL 575

  Fly   584 STRLQQC--VEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKHLRPPLLEKMPAMQISRISSQN 646
            |.|....  :|:::.||.|:....::.||.:..::...|.....::..:||.||..:.......|
Yeast   576 SVRFHDAKNIEKLRQLILSYTDSTDLSLQMKSNQYEIFFNQSISVKKIILETMPKFEKITEEQDN 640

  Fly   647 GESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLG--STDLSAGGAGDLV 709
            |::...:...|.|                            .::|.||||  |...|....||.|
Yeast   641 GKALSKNLISNEP----------------------------VDLLSDLLGEDSKAESKASTGDNV 677

  Fly   710 AATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDN 774
            ...|:...:..:.    || :|.|..|.:..:.:
Yeast   678 KPIDILEEIFGEK----ND-IAQVPKNANKEESI------------------------------- 706

  Fly   775 NQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDL--ASMLGGLGAPPAASPSLAASAPVGNL 837
            |.|||...|                |..::|.:.|.:  :|.|.      ..:..|:|::.:.:|
Yeast   707 NHSSAVEAN----------------SGVTLPLDANKIYDSSSLN------VYASLLSANSGLAHL 749

  Fly   838 -IDGHAGSLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNT 901
             :...|.||::||....|      .|:..:||       |.||           |.::|.|:..
Yeast   750 DLYFQAKSLISDLKTFCA------VPKAQKLT-------LGQL-----------YPSSTINASQ- 789

  Fly   902 LDQYLLQAAVQRSFQLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYVLDGQQQV 963
                                          :..|.:::  :.:..|::|:::.:.|:|...:
Yeast   790 ------------------------------ICKQSLKI--SGSGKLKLRVKLDFHLNGSSSI 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:396262	211/606 (35%)
		Alpha_adaptinC2	869..972	CDD:197886	11/95 (12%)
APL4	NP_015354.1	Adaptin_N	21..617	CDD:396262	214/609 (35%)
		Alpha_adaptinC2	727..828	CDD:197886	25/156 (16%)