DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1gamma and GBA2

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_006716872.1	Gene:	GBA2 / 57704	HGNCID:	18986	Length:	933	Species:	Homo sapiens

Alignment Length:	388	Identity:	70/388 - (18%)
Similarity:	126/388 - (32%)	Gaps:	144/388 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIH---MLGYPA-HFGQLECLKL 114
            |:...::..:.|.....:|.      ..|||       .:|:..:   .:||.. .||...||
Human    41 QVTDCKSPEDSRPPKETDCC------NPEDS-------GQLMVSYEGKAMGYQVPPFGWRICL-- 90

  Fly   115 TASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKN---------------DLNSSTQFV----- 159
              :..||:||..:          |..::.::|.:|:               .:...|.|:
Human    91 --AHEFTEKRKPF----------QANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINS 143

  Fly   160 VGLAL---CTLGAIASPEMARDLASEVERLMKSPNTYIRK-----------KATLCAFRVIRRV- 209
            |.|..   |.||.|....:.|....:..|...:|..|..:           |.|:|..|..:.|
Human   144 VPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQPICPLKFTVCLRREGQTVY 208

  Fly   210 PELMEIFLPATRSLLSEKNHGIL------------------ITGVTLITEMCENSSDTLMHFKKD 256
            .:::.:..|   |:|...|.|:.                  :.|.. :|..|...:..|.|..:|
Human   209 QQVLSLERP---SVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQN-VTLTCRQITPILPHDYQD 269

  Fly   257 S--------------GNREIVPNLVRILKNLILGGYSPEHDVSG--VSDPFLQVKILRLLR-ILG 304
            |              |:..:..:::..::|.:.||    .|..|  .::||...:....:| :|.
Human   270 SSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGG----DDAPGGLWNEPFCLERSGETVRGLLL 330

  Fly   305 HN---------------------------DPDAS--EAMNDIL------AQVATNTETSKNVG 332
            |:                           |||::  :...|:|      :....:|.|.|.||
Human   331 HHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQDGQLDSPTGQSTPTQKGVG 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	68/374 (18%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
GBA2	XP_006716872.1	GBA2_N	166..461	CDD:289023	41/236 (17%)
		DUF608	527..890	CDD:282531
		GDE_C	<625..>753	CDD:283786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900