DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and ap4e1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_699042.2	Gene:	ap4e1 / 570467	ZFINID:	ZDB-GENE-061221-3	Length:	1121	Species:	Danio rerio

Alignment Length:	955	Identity:	216/955 - (22%)
Similarity:	385/955 - (40%)	Gaps:	187/955 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TEAVERVRMPTPT-------------RLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREE--- 82
            ::.||:.....|:             ||:.||:.|....:..:|.:::.:|.    |..:|:
Zfish     2 SDVVEKTLTALPSLFDSQTGAAKISNRLKQLIKSITELTSKHDEESLIKQEL----SAMKEQVSA 62

  Fly    83 --DSVWRCRNI-AKLLYIHMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLI 144
              .|:.:.|.| .:.:|..||||.|.|..:..:||.......:||:|||...|.|.|..::.||:
Zfish    63 PSTSMKQMREIMVRSMYCEMLGYDASFSYIHAIKLAQQGGVMEKRVGYLAVSLFLSEGHELLLLL 127

  Fly   145 TNCLKNDLNSSTQFVVGLALCTLGAIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRV 209
            .|.:..||.|:......:||..:..:...:|...:...||..:..|...||:||.|..::.....
Zfish   128 VNTVLKDLQSTNLIEACMALTVVAQVFPKDMIPAVLPLVEDKLSHPKEIIRRKAVLALYKFYLIA 192

  Fly   210 PELMEIFLPATRSLLSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLI 274
            |..::......|..|.:|:.|::.:.:.:..::.:.|.|..         :::..:.|.|||.::
Zfish   193 PNQVQHIHAKFRKALCDKDPGVMTSSLHIYLQLIQESPDAY---------KDLTGSFVTILKQVV 248

  Fly   275 LGGYSPEHDVSGVSDPFLQVKILRLLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYET 339
            .|....:.:...|..|:||:::||:|.:||.:|...||.|.::|.:.....|.:.|:...||:|.
Zfish   249 GGKLPLDFNYHSVPAPWLQIQLLRILSLLGRDDQSTSELMYEVLDESLRRAEMNHNITYAILFEC 313

  Fly   340 VLSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDP 404
            |.::..|..:..|...|...:|.|:|:...|::|:.|..|...|..|.....:|:.||:|||...
Zfish   314 VKAVYTIHPKAELLEKAARCIGNFVLSPKINLKYLGLKALTYVVQHDAKLALQHQMTIIECLDHS 378

  Fly   405 DVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMIL-AAERYSPTTRWHLDT 468
            |.:|:|..:||.|.:.||||:..:.:::|.||.....|......:|.:. .||:::|...|.:.|
Zfish   379 DFTIKRETLELLFRITNAQNVSVIVEKMLDFLRSCSDEHTIIHLAGKVAELAEKFAPDNSWFIQT 443

  Fly   469 QLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQ------TYITNRFWESLQ-VANHCEDKQPLLQV 526
            ...|....|:.::.|:.::.::|::.....::      .|..:.:...|. .|:|.  .|..:||
Zfish   444 MNDVFSIGGDLLQQDISNNFLRLLAEGSESKEEDDQLRLYAVDSYLTLLNGDASHL--PQRFIQV 506

  Fly   527 AVWAIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCV 591
            ..|.:|||..|         .|...:|::|.:..|.|....||:.::.:.|.:|.|:|......:
Zfish   507 MSWVVGEYSHL---------QECVDQSEVIRLLMKLLEQKSVSSETRVWILSALTKISDGQTDLI 562

  Fly   592 EEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKHLRPPLLEKMPAMQISRISSQNGESGGGSFDD 656
            .|   |..|..|..:..|:|:..|.       :||  .|..|:....:.|         |.::||
Zfish   563 LE---LAESISSSQDTILRQQAHEL-------RHL--SLDSKLHEWVLPR---------GAAWDD 606

  Fly   657 NSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATDLSNAVHKK 721
            ..                  ::|:::        .||...|..|:||.            |.:|.
Zfish   607 ME------------------VDSSLS--------FLDGFVSEALAAGA------------APYKP 633

  Fly   722 NSRNANDVVAPVSNNQDLLDL------LDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSSAA 780
            ..:...::.     .|..|:|      |.:.||:.|.|...:|.......|:.....:.:|.:.|
Zfish   634 PHQRQEELC-----EQRALNLEPYSFSLPVSLSSCSITDRHSPTLLSVSSGLSGNSTELSQKAGA 693

  Fly   781 NMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAASAPVG---------- 835
            :...:.|...:.|....|....:..|             |.|...|| ||..|||
Zfish   694 STLILEGVKRVWGKDGYLPQKETAVT-------------ASPVDEPS-AAVQPVGQQEAAERLEP 744

  Fly   836 --------NLIDGHAGSLLADLNPTAASNNVV----VP---------PQGPRLTALDKDGLLVQL 879
                    |.....|.||...|: |.:|.:::    .|         |.|..|::....|
Zfish   745 QPEPSTQTNDKQQLASSLFVGLS-TQSSTSLLGKSEAPPPRFRKKPRPHGSSLSSSSSSG----- 803

  Fly   880 VSVRGSDCMRIYMTTTNNSDNTLDQYLLQAAVQRSFQLQMLTPSG 924
            .|.:.|        ::..|.||.|.:|..:.::..       |:|
Zfish   804 TSEKSS--------SSRTSHNTTDSFLYGSLLEEE-------PAG 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	144/569 (25%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	10/56 (18%)
ap4e1	XP_699042.2	Adaptin_N	45..592	CDD:279882	148/582 (25%)
ap4e1	XP_699042.2	AP4E_app_platf	1016..1116	CDD:291473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920