DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and ap3d1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_009294538.1	Gene:	ap3d1 / 563359	ZFINID:	ZDB-GENE-050208-437	Length:	1270	Species:	Danio rerio

Alignment Length:	680	Identity:	162/680 - (23%)
Similarity:	267/680 - (39%)	Gaps:	205/680 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LRDLIRQIRAARTAAEERAVVNKECA-YIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHFGQLEC 111
            |:||:|.||..:   |:.|.....|. .|:...::::...:...:.||.|:.||||...:.....
Zfish    18 LQDLVRGIRNHK---EDEAKYISTCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDVSWAAFNI 79

  Fly   112 LKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASPEMA 176
            :::.:|::||.||||||.|.....|..||.:|.||.::.||:|..|:..|:||..|....:|::|
Zfish    80 VEVMSSSKFTYKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPNQYDTGVALTGLSCFVTPDLA 144

  Fly   177 RDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGVTLITE 241
            ||||:::..||.....||||||.|..::|..:.||.:....|..:..|.:.:.|:....|.:|.|
Zfish   145 RDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICE 209

  Fly   242 MC-ENSSDTL----MHFK--KDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRL 299
            :. .|..:.|    :.||  ..|.|..:   |::|:|  :.|..:|       .:|.|..|::..
Zfish   210 LARRNPKNYLSLAPLFFKLMTSSTNNWV---LIKIIK--LFGALTP-------LEPRLGKKLIEP 262

  Fly   300 LRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYE---TVLSIMDIRSEG-----GLRVLA 356
            |..|.|    ::.||                   ::|||   ||::::...|.|     ....|.
Zfish   263 LTNLIH----STSAM-------------------SLLYECVNTVIAVLISLSSGMPNHSASIQLC 304

  Fly   357 VNILGRFLLNSDKN--------IRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAM 413
            |..|...:.:||:|        ::|:.|..:.:.:.....:||.|:..||:||.|.|.|||.||:
Zfish   305 VQKLRILIEDSDQNCEPSVNACMKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRAL 369

  Fly   414 ELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGN 478
            :|.:.:::.:|:..:.|:|:|.::||:                                    |.
Zfish   370 DLLYGMVSKKNLMEIVKKLMLHVDKAE------------------------------------GT 398

  Fly   479 YVRDDVVSSTIQLVSSSPVPEQTYITNRFW----------------------ESLQVA------- 514
            ..||::::..|.:.|.|   ...||||..|                      :.|.||
Zfish   399 TYRDELLTKIIDICSQS---NYQYITNFEWYISILVELTRLEGTRHGHLIASQMLDVAIRVKAIR 460

  Fly   515 ------------------------NHCEDKQPLLQVAVWAIGEYGD------------------- 536
                                    ..||    :|..|.|..||:.:
Zfish   461 AFAVAQMATLLDNAHLLTGNTQRNGICE----VLYAAAWICGEFAEHLEDPMLTLEAMLRPKVAT 521

  Fly   537 ---------------LFM------YGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSL 580
                           ||.      .|..:.:..:.|...||.....|:.||.:....:...::.|
Zfish   522 LPGHIQAVYVQNAAKLFATVLQKHEGETDSQAAQETSQLLIDRLPLFVQSANLEVQERASCILQL 586

  Fly   581 AKLSTRLQQ----CVEEIQALITSFGSHLN 606
            .|...:|||    ..||:.||   |...||
Zfish   587 VKYIQKLQQKNVEVAEEVTAL---FAGELN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	154/660 (23%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
ap3d1	XP_009294538.1	Adaptin_N	32..588	CDD:279882	144/633 (23%)
		HEAT repeat	151..172	CDD:293787	9/20 (45%)
		Cnd1	155..265	CDD:289487	32/121 (26%)
		HEAT repeat	185..209	CDD:293787	5/23 (22%)
		HEAT repeat	221..250	CDD:293787	8/33 (24%)
		HEAT repeat	258..293	CDD:293787	12/57 (21%)
		HEAT repeat	302..332	CDD:293787	7/29 (24%)
		HEAT repeat	343..372	CDD:293787	14/28 (50%)
		BLVR	669..813	CDD:283923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910