DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and gba2

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_005172389.1	Gene:	gba2 / 559240	ZFINID:	ZDB-GENE-070522-3	Length:	851	Species:	Danio rerio

Alignment Length:	239	Identity:	47/239 - (19%)
Similarity:	79/239 - (33%)	Gaps:	73/239 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LGAIASPEMARDLASEVERLMKSPNTY-----IRKKATLCAFRVIRRVPELM--EIFLPATRSLL 224
            ||.|....:.|....|..|...:|..|     |..:.|:|    :||..:.:  ::......|.|
Zfish    98 LGGIGGGSITRGWRGEFCRWQLNPGMYHYKTVIANQFTVC----LRRDGQTVYQQVLSTERPSTL 158

  Fly   225 SEKN----------HGILITGVTL-------ITEMCENSSDTLMHFKKDSGNREIVPNLVRILKN 272
            ...|          ||:.....|:       :|..|...|..:.|..|||.    :|..|.:
Zfish   159 QGWNWGYCGEHAFYHGLFPRAWTVYNLPGQNVTLTCRQVSPVIPHDYKDSS----LPVAVFV--- 216

  Fly   273 LILGGYSPEHDVSGVSDPFLQVKILRLL---------RILGH-NDPDASEAMNDILAQVATNTET 327
                     .|:...:|..|.:.|:..:         :..|| |:|...|...:.::.|..:.:|
Zfish   217 ---------WDIENKNDYALDISIMFTMVNGSGQKDDKSGGHWNEPFHLEKEGESVSGVLLHHQT 272

  Fly   328 SKN-----------VGNTILYETVLS--------IMDIRSEGGL 352
            ..|           .|..|.::|..|        ..|:.::|.|
Zfish   273 PANPYTLCIAARQKSGQEISHQTAFSPKGTCSAVWCDLMTDGRL 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	47/239 (20%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
gba2	XP_005172389.1	GBA2_N	105..399	CDD:289023	44/232 (19%)
		DUF608	469..836	CDD:282531
		GDE_C	<567..>694	CDD:283786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900