DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and ap2a2

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_031755830.1	Gene:	ap2a2 / 407867	XenbaseID:	XB-GENE-486024	Length:	1011	Species:	Xenopus tropicalis

Alignment Length:	778	Identity:	205/778 - (26%)
Similarity:	368/778 - (47%)	Gaps:	109/778 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
Frog     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65

  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162
            .:||:...||.:|.:.|.:|.::|:|:||||...:|::...::..||.|.:||||:|.....:||
Frog    66 FLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMGL 130

  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELM--EIFLPATRSL 223
            ||..:..:.|.|||...|.|:.|::.:.:|.  :::.|.||..|:.|..|:|:  ..:......|
Frog   131 ALHCIANVGSREMAEAFAGEIPRILVAGDTMDSVKQSAALCLLRLYRTSPDLVLTNEWTSRVVHL 195

  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286
            |::::.|::....:|||.:.:.:.:   .||..      |...|..|..::....:...|.:  .
Frog   196 LNDQHLGVVTAATSLITTLAQKNPE---EFKTS------VSLAVSRLSRIVTSASTDLQDYTYYF 251

  Fly   287 VSDPFLQVKILRLLRILGHNDPDA-----SEAMNDILAQVATNTETSK----NVGNTILYETVLS 342
            |..|:|.||:||||:.....:..|     :|.:..||.:.....::.|    |..|.:|:|.:..
Frog   252 VPAPWLSVKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISL 316

  Fly   343 IMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK-DP 404
            |:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..|| :.
Frog   317 IIYHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTER 381

  Fly   405 DVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQ 469
            |||:|:||::|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|::||.
Frog   382 DVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTI 446

  Fly   470 LSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEY 534
            |:::..||:||.::|....||:|.:.. ..|.|.....:|:|| |..|.:.  |::|..:.:||:
Frog   447 LNLIRIAGDYVSEEVWYRVIQIVINRD-DVQGYAAKTVFEALQ-APACHEN--LVKVGGYILGEF 507

  Fly   535 GD----------LFMYGANEDEFER---PTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTR 586
            |:          |..:.....:|..   ||.:.|::.|.||:.......|:.|..|.|.::|
Frog   508 GNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSAYIKFINLFPEIKTTIQDVLRSDSQL--- 569

  Fly   587 LQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKH-LRPPLLEKMPAMQ------ISRISS 644
                            .:.:|:||||.||:.:|.....: :...:||:||...      ::::..
Frog   570 ----------------RNADVELQQRAVEYLRLSSIASNDILATVLEEMPPFPERESSILAKLKK 618

  Fly   645 QNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDN----------TNILLDLLGSTD 699
            :.|.|.....::...:  ::..:..|...|:.:.:....:.::          .::|:..|.|:.
Frog   619 KKGPSTVTDLEETKKE--KSNSDLNGITEHAPLSTTQQPVFEDKATYAVRQRPLSLLVPTLSSSQ 681

  Fly   700 LSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLD-LSAPSSTTTGAPAGG 761
            ....|....|||.....:....::                 |||.|. .|..|||.|.||:.|
Frog   682 SLYSGTSHRVAALPFCQSTPSPSA-----------------DLLGLGAASGSSSTPTTAPSAG 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	170/589 (29%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
ap2a2	XP_031755830.1	Adaptin_N	29..591	CDD:396262	171/593 (29%)
		HEAT repeat	332..355	CDD:293787	10/22 (45%)
		HEAT repeat	369..398	CDD:293787	12/28 (43%)
		HEAT repeat	408..434	CDD:293787	7/25 (28%)
		Alpha_adaptinC2	789..892	CDD:197886
		Alpha_adaptin_C	898..1006	CDD:367023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920