DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and Ap3d1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001094189.1	Gene:	Ap3d1 / 314633	RGDID:	1308659	Length:	1204	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	164/642 - (25%)
Similarity:	290/642 - (45%)	Gaps:	112/642 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LRDLIRQIRAARTAAEERAVVNKECA-YIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHFGQLEC 111
            |:||:|.||..:   |:.|....:|. .|:...::::...:...:.||.|:.||||...:.....
  Rat    18 LQDLVRGIRNHK---EDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNI 79

  Fly   112 LKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASPEMA 176
            :::.::::||.||:|||.|.....|..||.:|.||.::.||:|.:|:..|:||..|....:|::|
  Rat    80 IEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLA 144

  Fly   177 RDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGVTLITE 241
            ||||:::..||.....||||||.|..::|..:.||.:....|..:..|.:.:.|:....|.:|.|
  Rat   145 RDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICE 209

  Fly   242 MC-ENSSDTL----MHFK--KDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRL 299
            :. .|..:.|    :.||  ..|.|..:   |::|:|  :.|..:|       .:|.|..|::..
  Rat   210 LARRNPKNYLSLAPLFFKLMTSSTNNWV---LIKIIK--LFGALTP-------LEPRLGKKLIEP 262

  Fly   300 LRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYE---TVLSIMDIRSEG-----GLRVLA 356
            |..|.|    ::.||                   ::|||   ||::::...|.|     ....|.
  Rat   263 LTNLIH----STSAM-------------------SLLYECVNTVIAVLISLSSGMPNHSASIQLC 304

  Fly   357 VNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALIN 421
            |..|...:.:||:|::|:.|..:.:.:.....:||.|:..||:||.|.|.|||.||::|.:.:::
  Rat   305 VQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVS 369

  Fly   422 AQNIRTMTKELLLFLEKAD-AEFKAQCSSGM--ILAAERYSPTT--RWHLD----------TQLS 471
            .:|:..:.|:|:..::||: ..::.:..:.:  |.:...|...|  .|::.          |:..
  Rat   370 KKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHG 434

  Fly   472 VLIAAG--------NYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAV 528
            .||||.        ..:|...||....|:.|:.:..         .|.|....||    :|..|.
  Rat   435 HLIAAQMLDVAIRVKAIRKFAVSQMSSLLDSAHLVA---------SSTQRNGICE----VLYAAA 486

  Fly   529 WAIGEYGDLFMYGANE--DEFERPTESDL----IAVYYKFLTSAQVSTTSKQYALVSLAKLSTRL 587
            |..||:.: .:.|..:  :...||..:.|    .|||        |....|.||.:...|.....
  Rat   487 WICGEFSE-HLQGPQQTLEAMLRPKVTTLPGHIQAVY--------VQNVVKLYASILQQKEQAAD 542

  Fly   588 QQCVEEIQALIT----SFGSHLNVDLQQRGVEFTQLFGHYKHLRP---PLLEKMPAM 637
            .:..:|:..|:.    .|....::::|:|.....||..|.:.|:.   |:.|::.|:
  Rat   543 TEGAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKGVPVAEEVSAL 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	152/604 (25%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
Ap3d1	NP_001094189.1	Adaptin_N	32..581	CDD:279882	152/605 (25%)
		HEAT repeat	151..172	CDD:293787	9/20 (45%)
		Cnd1	155..265	CDD:289487	32/121 (26%)
		HEAT repeat	184..212	CDD:293787	6/27 (22%)
		HEAT repeat	220..262	CDD:293787	12/53 (23%)
		HEAT repeat	271..292	CDD:293787	7/39 (18%)
		HEAT repeat	301..330	CDD:293787	8/28 (29%)
		HEAT repeat	335..364	CDD:293787	14/28 (50%)
		BLVR	661..803	CDD:283923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810