DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and Ap4e1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001178671.1	Gene:	Ap4e1 / 311404	RGDID:	1562199	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	1057	Identity:	241/1057 - (22%)
Similarity:	420/1057 - (39%)	Gaps:	203/1057 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RMPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRN--IAKLLYIHMLGYP 103
            |.|..:||..|||.:.|..:..||..::.:|.:.:::|.....:..:...  :.:|:|..||||.
  Rat    28 RAPFFSRLGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYD 92

  Fly   104 AHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLG 168
            |.||.:..:||.......:||:|||...|.|.|..::.||:.|.:..||.|:....|.:||..:.
  Rat    93 ASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVS 157

  Fly   169 AIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILI 233
            .|...||...:...:|..::.....||:||.|..::.....|..::......|..|.:::.|::.
  Rat   158 QIFPREMIPAVLPLIEEKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHTKFRKALCDRDVGVMA 222

  Fly   234 TGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILR 298
            ..:.:...|.:.:|         ||.:::..:.|.|||.::.|....|.....|..|:||:::||
  Rat   223 ASLHIYLRMIKENS---------SGYKDLTESFVTILKQVVGGKLPVEFSYHSVPAPWLQIQLLR 278

  Fly   299 LLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRF 363
            :|.:||.:|...||.|.|:|.:.....|.:.||...||:|.|.:|..|..:..|...|...:|:|
  Rat   279 ILGLLGKDDERTSELMYDVLDESLRRAELNHNVTYAILFECVHTIYSIYPKSELLEKAAKCIGKF 343

  Fly   364 LLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTM 428
            :|:...|::|:.|..|...:..|.|...:|:.||:|||..||..|:|..:||.:.:.||||:..:
  Rat   344 VLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETLELLYRITNAQNVVVI 408

  Fly   429 TKELLLFLEKADAEFKAQCSSGMIL-AAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLV 492
            .:::|.:|.::..|:......|.|. .||:|:|...|.:.|..:|....|:.:..|::|:.::|:
  Rat   409 VQKMLEYLHQSKEEYIIINLVGKIAELAEKYAPDNVWFIQTMNAVFSVGGDVMHPDILSNFLRLL 473

  Fly   493 SSSPVPE-----------QTYIT-----NRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYG 541
            :.....|           |:|:|     |.|:           .|..|||..|.:|||..|
  Rat   474 AEGFDDETEDQQLRLYAVQSYLTLLDMENTFY-----------PQRFLQVMSWVLGEYSYL---- 523

  Fly   542 ANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLN 606
                 .:|.:...::...||.|.|..:|:.:|.:...::.||:.:.... ..::.||..|...||
  Rat   524 -----LDRESPEAVMTRLYKLLRSDSISSETKAWLFAAVTKLTPQAHSS-PIVENLIQEFTVSLN 582

  Fly   607 VDLQQRGVEFTQLFGHYKHLRPPLLE------------------------------------KMP 635
            ..|:|...|...|..: :.|...||:                                    :..
  Rat   583 TCLRQHAFELKHLHEN-EELMKSLLQSAQNCDDIMADASLSFLDGFVAEGLSQGAAPYKPRHQRQ 646

  Fly   636 AMQISRISSQNGESGGGSFDDN------SPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDL 694
            ..|:|:....|.|..|.||..:      ||..:..|.:..|....:.::...:...|....|...
  Rat   647 EEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGVSLGSDISGNSAETGLKEAGSLKMDGIKKLWGK 711

  Fly   695 LGSTDLSAGGAGDLVAAT----------DLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDL-- 747
            .|.......||.|.:.|.          ::..|:.:|:....:.........|.|...|.:.|
  Rat   712 EGYLPKKESGAADKLEAAHAPAESAMMENVDQAMTRKDQAQGHTPSTEEKEKQLLASSLFVGLGP 776

  Fly   748 -----------------------------------SAPSSTTTGAPAGGGGGGGIVALVGDNNQS 777
                                               :|||||.  :|.....|       ||.:..
  Rat   777 ENTINLLGKADVVSYKFRRKSKPKVAQSDKMPSAHAAPSSTL--SPVSDVAG-------GDEDSL 832

  Fly   778 SAANMNNMLGGLDLGGFGSGLD-------SSASIPTN----GNDLASMLGGLGAPPAASPSLAAS 831
            |||:..:...|.:|.|..|.|:       ||.|:|.:    |||:.     :..||::|.:.|..
  Rat   833 SAADRGDGELGSELLGSESVLELPSVENLSSVSLPVSSLFAGNDME-----VFHPPSSSATSAVK 892

  Fly   832 APVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPRLTALD---KDGLLVQLVSVRGSDCMRIYMT 893
            ..          ||.|.|..|         |:..|...::   .:.:.|....|...:|:.:..:
  Rat   893 EV----------SLAALLEET---------PECRRSALVEICSNETVAVSSYKVWKDECLLLVCS 938

  Fly   894 TTNNSDNTLDQYLLQAAVQRSFQLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYVLD 958
            .|:.:|:......|:.....:|:         ::...|..:..|...:|.:        .||.:.
  Rat   939 VTSKTDSEFTDAQLEIFPLENFK---------IIEQPGCPSPVMEAESTKS--------FQYGVQ 986

  Fly   959 GQQQVEQTEVSGFPEQQ 975
            .:....:..:|||.:.|
  Rat   987 MESPCVEGTLSGFIKYQ 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	153/574 (27%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	14/105 (13%)
Ap4e1	NP_001178671.1	Adaptin_N	51..595	CDD:279882	153/573 (27%)
Ap4e1	NP_001178671.1	AP4E_app_platf	1026..1125	CDD:291473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820