Protein Alignment AP-1gamma and Ap4e1

DIOPT Version :10

• Sequence 1: NP_788891.2
• Gene: AP-1gamma / 31842
• FlyBaseID: FBgn0030089
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_001178671.1
• Gene: Ap4e1 / 311404
• RGDID: 1562199
• Length: 1130
• Species: Rattus norvegicus
• Alignment Length: 1057
• Identity: 241/1057 - (22%)
• Similarity: 420/1057 - (39%)
• Gaps: 203/1057 - (19%)

  Fly    41 RMPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRN--IAKLLYIHMLGYP 103
            |.|..:||..|||.:.|..:..||..::.:|.:.:::|.....:..:...  :.:|:|..||||.
  Rat    28 RAPFFSRLGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYD 92

  Fly   104 AHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLG 168
            |.||.:..:||.......:||:|||...|.|.|..::.||:.|.:..||.|:....|.:||..:.
  Rat    93 ASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVS 157

  Fly   169 AIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILI 233
            .|...||...:...:|..::.....||:||.|..::.....|..::......|..|.:::.|::.
  Rat   158 QIFPREMIPAVLPLIEEKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHTKFRKALCDRDVGVMA 222

  Fly   234 TGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILR 298
            ..:.:...|.:.:|         ||.:::..:.|.|||.::.|....|.....|..|:||:::||
  Rat   223 ASLHIYLRMIKENS---------SGYKDLTESFVTILKQVVGGKLPVEFSYHSVPAPWLQIQLLR 278

  Fly   299 LLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRF 363
            :|.:||.:|...||.|.|:|.:.....|.:.||...||:|.|.:|..|..:..|...|...:|:|
  Rat   279 ILGLLGKDDERTSELMYDVLDESLRRAELNHNVTYAILFECVHTIYSIYPKSELLEKAAKCIGKF 343

  Fly   364 LLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTM 428
            :|:...|::|:.|..|...:..|.|...:|:.||:|||..||..|:|..:||.:.:.||||:..:
  Rat   344 VLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETLELLYRITNAQNVVVI 408

  Fly   429 TKELLLFLEKADAEFKAQCSSGMIL-AAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLV 492
            .:::|.:|.::..|:......|.|. .||:|:|...|.:.|..:|....|:.:..|::|:.::|:
  Rat   409 VQKMLEYLHQSKEEYIIINLVGKIAELAEKYAPDNVWFIQTMNAVFSVGGDVMHPDILSNFLRLL 473

  Fly   493 SSSPVPE-----------QTYIT-----NRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYG 541
            :.....|           |:|:|     |.|:           .|..|||..|.:|||..|
  Rat   474 AEGFDDETEDQQLRLYAVQSYLTLLDMENTFY-----------PQRFLQVMSWVLGEYSYL---- 523

  Fly   542 ANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLN 606
                 .:|.:...::...||.|.|..:|:.:|.:...::.||:.:.... ..::.||..|...||
  Rat   524 -----LDRESPEAVMTRLYKLLRSDSISSETKAWLFAAVTKLTPQAHSS-PIVENLIQEFTVSLN 582

  Fly   607 VDLQQRGVEFTQLFGHYKHLRPPLLE------------------------------------KMP 635
            ..|:|...|...|..: :.|...||:                                    :..
  Rat   583 TCLRQHAFELKHLHEN-EELMKSLLQSAQNCDDIMADASLSFLDGFVAEGLSQGAAPYKPRHQRQ 646

  Fly   636 AMQISRISSQNGESGGGSFDDN------SPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDL 694
            ..|:|:....|.|..|.||..:      ||..:..|.:..|....:.::...:...|....|...
  Rat   647 EEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGVSLGSDISGNSAETGLKEAGSLKMDGIKKLWGK 711

  Fly   695 LGSTDLSAGGAGDLVAAT----------DLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDL-- 747
            .|.......||.|.:.|.          ::..|:.:|:....:.........|.|...|.:.|
  Rat   712 EGYLPKKESGAADKLEAAHAPAESAMMENVDQAMTRKDQAQGHTPSTEEKEKQLLASSLFVGLGP 776

  Fly   748 -----------------------------------SAPSSTTTGAPAGGGGGGGIVALVGDNNQS 777
                                               :|||||.  :|.....|       ||.:..
  Rat   777 ENTINLLGKADVVSYKFRRKSKPKVAQSDKMPSAHAAPSSTL--SPVSDVAG-------GDEDSL 832

  Fly   778 SAANMNNMLGGLDLGGFGSGLD-------SSASIPTN----GNDLASMLGGLGAPPAASPSLAAS 831
            |||:..:...|.:|.|..|.|:       ||.|:|.:    |||:.     :..||::|.:.|..
  Rat   833 SAADRGDGELGSELLGSESVLELPSVENLSSVSLPVSSLFAGNDME-----VFHPPSSSATSAVK 892

  Fly   832 APVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPRLTALD---KDGLLVQLVSVRGSDCMRIYMT 893
            ..          ||.|.|..|         |:..|...::   .:.:.|....|...:|:.:..:
  Rat   893 EV----------SLAALLEET---------PECRRSALVEICSNETVAVSSYKVWKDECLLLVCS 938

  Fly   894 TTNNSDNTLDQYLLQAAVQRSFQLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYVLD 958
            .|:.:|:......|:.....:|:         ::...|..:..|...:|.:        .||.:.
  Rat   939 VTSKTDSEFTDAQLEIFPLENFK---------IIEQPGCPSPVMEAESTKS--------FQYGVQ 986

  Fly   959 GQQQVEQTEVSGFPEQQ 975
            .:....:..:|||.:.|
  Rat   987 MESPCVEGTLSGFIKYQ 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:396262	153/574 (27%)
		Alpha_adaptinC2	869..972	CDD:197886	14/105 (13%)
Ap4e1	NP_001178671.1	Adaptin_N	51..592	CDD:396262	152/570 (27%)
		AP4E_app_platf	1026..1126	CDD:464326