DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1gamma and Ap2a1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001382021.1	Gene:	Ap2a1 / 308578	RGDID:	1306254	Length:	977	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	250/985 - (25%)
Similarity:	425/985 - (43%)	Gaps:	222/985 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
  Rat     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65

  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162
            .:||:...||.:|.:.|.:|.::|:|:||||...:|::...::..||.|.:||||.|.....:.|
  Rat    66 FLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCL 130

  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPATRSL 223
            ||..:..:.|.||....|:::.|::.:.::.  :::.|.||..|:.:..|:|:.:  :......|
  Rat   131 ALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHL 195

  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286
            |::::.|::...|:|||.:|:.:.|..         :..|...|..|..::....:...|.:  .
  Rat   196 LNDQHMGVVTAAVSLITCLCKKNPDDF---------KTCVSLAVSRLSRIVSSASTDLQDYTYYF 251

  Fly   287 VSDPFLQVKILRLLRILGHNDP-DAS------EAMNDILAQVATNTETSK----NVGNTILYETV 340
            |..|:|.||:||||:.  :..| ||:      |.:..:|.:.....::.|    |..|.||:||:
  Rat   252 VPAPWLSVKLLRLLQC--YPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETI 314

  Fly   341 LSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK- 402
            ..|:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..||
  Rat   315 SLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKT 379

  Fly   403 DPDVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLD 467
            :.|||:|:||.:|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|::|
  Rat   380 ERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVD 444

  Fly   468 TQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIG 532
            |.|:::..||:||.::|....:|:|::.. ..|.|.....:|:|| |..|.:.  :::|..:.:|
  Rat   445 TILNLIRIAGDYVSEEVWYRVLQIVTNRD-DVQGYAAKTVFEALQ-APACHEN--MVKVGGYILG 505

  Fly   533 EYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQAL 597
            |:|:|.   |.:.....|.:..|:  :.||   ...|..::...|.:..|......:....||.:
  Rat   506 EFGNLI---AGDPRSSPPVQFSLL--HSKF---HLCSVATRALLLSTYIKFINLFPETKATIQGV 562

  Fly   598 ITSFGSHL---NVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRISSQNGESGG 651
            :.: ||.|   :|:||||.||:        |.:........||..|:..:: ::::..:.|....
  Rat   563 LRA-GSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSI-LAKLKRKKGPGAA 625

  Fly   652 GSFDDNSPDVIENGVEGGGGGGHSLIE---SNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATD 713
            .:.||:..|...|.:.||       :|   ||::|
  Rat   626 SALDDSRRDTSSNDINGG-------VEPTPSNVST------------------------------ 653

  Fly   714 LSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSS 778
                               .|.:.|||.|    .:||......||.||
  Rat   654 -------------------PSPSADLLGL----RAAPPPAAPPAPVGG----------------- 678

  Fly   779 AANMNNMLGGLDLGGFGSGLDSSASI-PTNGNDLASMLGGLGAPPAASPSLAASAPVGNLIDGHA 842
                 |:|  :|:  |..|..:..|: ||......|.|    .|||....:
  Rat   679 -----NLL--VDV--FSDGPTAQPSLGPTPEEAFLSEL----EPPAPESPM-------------- 716

  Fly   843 GSLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLL 907
             :||||..|.|......:.|..|     :.|.||.:.|      |        .||....:..||
  Rat   717 -TLLADPAPAADPGPEDIGPPIP-----EADELLNKFV------C--------KNSGVLFENQLL 761

  Fly   908 QAAVQRSF-----------------QLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQY 955
            |..|:..|                 |.|...|  :|:.||.:.||  ..|.|.        |:..
  Rat   762 QIGVKSEFRQNLGRMYLFYGNKTSVQFQSFLP--TVVHPGDLQTQ--LAVQTK--------RVAA 814

  Fly   956 VLDGQQQVEQ 965
            .:||..||:|
  Rat   815 QVDGGAQVQQ 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	168/589 (29%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	28/114 (25%)
Ap2a1	NP_001382021.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920