DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1gamma and AP4E1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_031373.2	Gene:	AP4E1 / 23431	HGNCID:	573	Length:	1137	Species:	Homo sapiens

Alignment Length:	797	Identity:	192/797 - (24%)
Similarity:	344/797 - (43%)	Gaps:	118/797 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRN--IAKLLYIHMLGYPAHFGQ 108
            :||..|:|.|.|..:..||..::.:|.:.:::|.....:..:...  :.:|:|..||||.|.||.
Human    34 SRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGY 98

  Fly   109 LECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASP 173
            :..:||.......:||:|||...|.|.|..::.||:.|.:..||.|:....|.:||..:..|...
Human    99 IHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPC 163

  Fly   174 EMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGVTL 238
            ||...:...:|..::.....:|:||.|..::.....|..::......|..|.:::.|::...:.:
Human   164 EMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHI 228

  Fly   239 ITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLLRIL 303
            ...|.:.:|         ||.:::..:.|.|||.::.|....|.:...|..|:||:::||:|.:|
Human   229 YLRMIKENS---------SGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLL 284

  Fly   304 GHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLNSD 368
            |.:|...||.|.|:|.:.....|.:.||...||:|.|.::..|..:..|...|...:|:|:|:..
Human   285 GKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPK 349

  Fly   369 KNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTMTKELL 433
            .|::|:.|..|...:..|.:...:|:.||:|||..||..|:|..:||.:.:.|||||..:.:::|
Human   350 INLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKML 414

  Fly   434 LFLEKADAEFKAQCSSGMIL-AAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPV 497
            .:|.::..|:......|.|. .||:|:|...|.:.|..:|....|:.:..|:.::.::|::....
Human   415 EYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFD 479

  Fly   498 PE-----------QTYIT-----NRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYGANEDE 546
            .|           |:|:|     |.|:           .|..|||..|.:|||..|
Human   480 DETEDQQLRLYAVQSYLTLLDMENVFY-----------PQRFLQVMSWVLGEYSYL--------- 524

  Fly   547 FERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLNVDLQQ 611
            .::.|..::||..||.|.:..||:.:|.:.:.::.||:::.... ..::.||..|...|:..::|
Human   525 LDKETPEEVIAKLYKLLMNDSVSSETKAWLIAAVTKLTSQAHSS-NTVERLIHEFTISLDTCMRQ 588

  Fly   612 RGVEFTQLFGHYKHLRPPLLEKMPAMQISRISSQNGESGGGSFDDNSPDVIENGVEGGGGGGHSL 676
            ...|.       |||... :|.|.::.              ..|.:..|::
Human   589 HAFEL-------KHLHEN-VELMKSLL--------------PVDRSCEDLV-------------- 617

  Fly   677 IESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNNQDLLD 741
            ::::::        .||...:..||.|.|.        ....|::.....        :.:.:|:
Human   618 VDASLS--------FLDGFVAEGLSQGAAP--------YKPPHQRQEEKL--------SQEKVLN 658

  Fly   742 LLDLDLSAPSSTTTG--APAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASI 804
            .....||..||..||  :|||       ::|..|.:.:||.........|.|.|..........:
Human   659 FEPYGLSFSSSGFTGRQSPAG-------ISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYL 716

  Fly   805 PTNGNDLASMLGGLGAP 821
            |...:......|.|..|
Human   717 PKKESKTGDESGALPVP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	149/574 (26%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
AP4E1	NP_031373.2	Adaptin_N	52..596	CDD:331138	151/580 (26%)
		Interaction with TEPSIN. /evidence=ECO:0000269\|PubMed:26542808	727..1137		3/7 (43%)
		AP4E_app_platf	1033..1132	CDD:317244
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820