DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and apa-2

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001370626.1	Gene:	apa-2 / 181163	WormBaseID:	WBGene00000161	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	960	Identity:	242/960 - (25%)
Similarity:	419/960 - (43%)	Gaps:	161/960 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYIHMLGYPAHFGQLECLK 113
            |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|.:||....||.:|.:.
Worm    16 ISDIRNCKSKEAELKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGNDIDFGHMEAVN 80

  Fly   114 LTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASPEMARD 178
            |.:|.::|:|:||||...:|::::.|:..||...::|||.|.....|.|||..:..:.|.||...
Worm    81 LLSSNKYTEKQIGYLFISVLIEQQSDLMKLIVQGIRNDLTSRNPVHVNLALQCISNMGSREMVEA 145

  Fly   179 LASEVERLMKSPNT--YIRKKATLCAFRVIRRVPELMEIFLPATR--SLLSEKNHGILITGVTLI 239
            ..:::.:|:.|..|  ::::.|.||..::.|..|:..:....|:|  .||::.:.|::.:..:||
Worm   146 FCTDLPKLLVSGETIDFVKQSAALCILKLFRNSPDSFQPGDYASRIVHLLNDSHMGVVTSAASLI 210

  Fly   240 TEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--GVSDPFLQVKILRLLRI 302
            ..:.:         |.....:..||..:..|..::...|:...|.:  .|..|:|.||:||||:
Worm   211 EALSK---------KWPEEYKGAVPLAISRLSRIVTATYTDLQDYTYYFVPAPWLCVKLLRLLQ- 265

  Fly   303 LGHNDPD-------ASEAMNDILAQVATNTETSK----NVGNTILYETVLSIMDIRSEGGLRVLA 356
             .:..||       ..|.:..||.:.....::.|    |..|.:|:|.:..|:.:.||..|.|.|
Worm   266 -NYPPPDDPSNKARLLECLEGILNKAQDAPKSKKVQHSNAKNAVLFEAIALIIHMDSEPQLLVRA 329

  Fly   357 VNILGRFLLNSDKNIRYVALNT--LLRTVHADTSAVQRHRTTILECLK-DPDVSIRRRAMELSFA 418
            .|.||.||.:.:.|:||:||.:  ||.|......||::|:.||:..|| :.|||:|:||::|.:|
Worm   330 CNQLGTFLSHRETNLRYLALESMCLLATSEFSHDAVKKHQDTIINSLKTERDVSVRQRAVDLLYA 394

  Fly   419 LINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDD 483
            :.:..|...:..|:|.:||.||...:.:....:.:.||:|:....|::|..|.::..||:||.::
Worm   395 MCDRSNANQIVAEMLAYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILKLIRIAGDYVSEE 459

  Fly   484 VVSSTIQLVSSSPVPEQTYITNRFWESLQ-VANHCEDKQPLLQVAVWAIGEYGDLFMYGANEDEF 547
            |....||:|.:.. ..|.|.....:|:|| .|.|    :.:::|..:.:||:|: |:.|.
Worm   460 VWYRVIQIVVNRE-DVQGYAAKTVFEALQRPACH----ENMVKVGGYILGEFGN-FIAGD----- 513

  Fly   548 ERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAK----LSTRLQQC--VEEIQALITS-FGSHL 605
            ||.|..    :.::.|.|        ::.|.|:..    |:|.::.|  ..||:.|:.. |.:..
Worm   514 ERSTAK----IQFELLHS--------KFHLCSITTRCLLLTTYIKFCNLFPEIKPLVQQVFQTDH 566

  Fly   606 NV-----DLQQRGVEFTQLFGHYKH-LRPPLLEKMPAM----------------QISRISSQNGE 648
            |:     :||||.:|:.|:.....: :...:||.|||.                |:..|..:..|
Worm   567 NLRNPDAELQQRSIEYLQMTKLASNDVLATILEVMPAFAEKESSLLAKLKKSKPQLEEIEREEKE 631

  Fly   649 SGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGS---TDLSAGG------ 704
            .      .:.|..:.:      .|..||::  .::..|.|..|.|:..:   |.|.|.|
Worm   632 K------RSKPTAVMS------EGSTSLVD--FDSTNDTTASLADVFANNSGTGLGAQGDEVEIA 682

  Fly   705 -AGDLVAATDLSNAV----------HKKNSRN---------ANDVVAPVSNNQDLL---DLLDLD 746
             ..|.:.....|||:          .|..:||         .|....|.:....::   ..|.:.
Worm   683 NKDDYLKFVTKSNAILWEDDYIQIGCKLETRNNLGRLGMFYGNKTSQPFNKFTPIITCPGALAVQ 747

  Fly   747 LSAPSSTTTGAPAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASI------- 804
            |.|.:.......|.|.....::..|..........||......|..|.....|.:..:
Worm   748 LQAQAKPVEPVVAAGTQVQQLINFVCVQEFQKMPIMNIKFTFTDRAGAVQNFDKNFYLPLFISKF 812

  Fly   805 --PTN--GNDLASMLGGLGAPP--------AASPSLAASAPVGNLIDGHAGSLLADLNPTAASNN 857
              |||  .....:....|||..        |.||  ...|.:.:.:.|...:||.|::|.  .:|
Worm   813 FEPTNMTSEQFFTRWKSLGAASQEAQKIFNALSP--IEHATIESRLKGFGANLLTDVDPN--PDN 873

  Fly   858 VVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLL 907
            .|.  .|...|...:.|.|::|...:.:   ::|..|..:|.:|:.|.|:
Worm   874 YVC--AGIIHTQTQQIGTLIRLEPNKQA---KMYRLTIRSSKDTVVQTLV 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	170/591 (29%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	9/39 (23%)
apa-2	NP_001370626.1	Adaptin_N	28..590	CDD:396262	171/595 (29%)
		Alpha_adaptinC2	698..806	CDD:197886	16/107 (15%)
		Alpha_adaptin_C	812..920	CDD:367023	28/116 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820