DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and apd-3

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_494570.1	Gene:	apd-3 / 173701	WormBaseID:	WBGene00000162	Length:	1251	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	174/804 - (21%)
Similarity:	310/804 - (38%)	Gaps:	226/804 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LRDLIRQIRAARTAAEERAVVNKECAYIRSTFRE------EDSVW-RCRNIAKLLYIHMLGYPAH 105
            |.||||.||..:         :.|..||.....|      :||:: :...|.||.|:.||||...
Worm    18 LTDLIRGIRNNK---------DNESRYITQCMEEIKQELRQDSIYVKANAIEKLAYLQMLGYDIS 73

  Fly   106 FGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAI 170
            :.....:::.|||::|:||||||.|.....:..||.:|.||.::.|:|||..:..|:||..|...
Worm    74 WASFNVIEVMASTKYTEKRIGYLAAAQSFHDETDVLMLTTNLIRKDVNSSNMYESGIALGGLSCF 138

  Fly   171 ASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITG 235
            .:|::|||||::|..|:.....|.||:|.|..:::..:.|:.:....|..:..|.:.:.|:..:.
Worm   139 VTPDLARDLAADVVNLLSCSRNYTRKRAVLLLYKIFLKYPDALRPTFPRLKEKLEDPDPGVQSSA 203

  Fly   236 VTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLL 300
            |.:|.|:..         |.......:.|...:::              :..|:.::.:||::|.
Worm   204 VNVICELAR---------KNPKNYLTLAPVFFKLM--------------TTSSNNWMLIKIIKLF 245

  Fly   301 RILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYE---TVLSIMDIRSEGGLRV----LAVN 358
            ..|...:|...:.:.:.|..:..:|...     ::|||   ||::::...|.||...    |.|.
Worm   246 GALVPLEPRLGKKLLEPLTNLINSTSAM-----SLLYECINTVIAVLISISAGGDHTASIQLCVQ 305

  Fly   359 ILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQ 423
            .||..:.:||:|::|:.|..:.:.:.....|||.|:..:|.||.|.|.|||.|:::|.:.:::.:
Worm   306 KLGVLIEDSDQNLKYLGLLAMGKILKTHPKAVQAHKDIVLRCLDDKDESIRIRSLDLLYGMVSKK 370

  Fly   424 NIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSST 488
            ||..:.|:|:..:|.|:                                    |::.||:::|..
Worm   371 NIVEIVKKLMEHVEAAE------------------------------------GSHYRDELLSRI 399

  Fly   489 IQLVSSSPVPEQTYITNRFW-------------------------------ESL----------- 511
            |.:.|.|   ...||||..|                               ||:
Worm   400 IGICSWS---NYQYITNFEWYISVLVELTKVEGTEHGAKIAEQIQDVTVRVESIRHFSVSQMALL 461

  Fly   512 -------------QVANHCEDKQPLLQVAVWAIGEYGD------------------------LFM 539
                         |.:|.||    :|..|.|..|||..                        |.:
Worm   462 VENAHVLLAGSAQQRSNMCE----VLLAAAWICGEYSQHVRNQQGVLESMLKAKPSVMPGHILSV 522

  Fly   540 YGAN--------------EDEFERPTESD--LIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQ 588
            |..|              ||:::.....|  :::...:|..|..:....:...|:::.::..:|.
Worm   523 YVQNIGKLYCSLMSQAEEEDDWDAIDSLDNLMLSKLPQFELSEHLEAQERACNLMAIIRIVEKLH 587

  Fly   589 QCVEEIQALITSFGSHLNVDLQQRGVEFTQLF-GHYKHLRPPLLEKMPAMQISRISSQNGESGGG 652
            |                  |.|:.|.|..:|: |....:......|:|......:.:..||....
Worm   588 Q------------------DRQKMGSEVQKLYDGELNPVATKAQRKVPVPDGLDLDAWIGEEWAA 634

  Fly   653 SFDDNSPDVIENGVE---GGGGGGHSLIESNMNTLGDNTNILLDL--LGSTDLSAGGAGDLVAAT 712
            :.:|.|.|  |:.:|   |.......::|:.     :...::.||  ||......|..|..:|.:
Worm   635 ASEDESDD--ESDIEEMFGAPATRPKMLENE-----EQEPVVQDLEELGGGKKKKGKNGAEIAMS 692

  Fly   713 DLSNAVHKKNSRNANDVVAPVSNN 736
              ...:.|:......:    :.||
Worm   693 --KEEIEKRRKLREQE----IENN 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	146/665 (22%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
apd-3	NP_494570.1	Adaptin_N	32..581	CDD:279882	138/619 (22%)
		Cnd1	153..265	CDD:289487	22/134 (16%)
		HEAT repeat	184..212	CDD:293787	6/27 (22%)
		HEAT repeat	223..247	CDD:293787	5/37 (14%)
		HEAT repeat	259..292	CDD:293787	7/37 (19%)
		HEAT repeat	302..332	CDD:293787	9/29 (31%)
		HEAT repeat	341..365	CDD:293787	10/23 (43%)
		BLVR	692..853	CDD:283923	3/25 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910