DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1gamma and Ap1g1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001380641.1	Gene:	Ap1g1 / 171494	RGDID:	619785	Length:	825	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	470/945 - (49%)
Similarity:	603/945 - (63%)	Gaps:	135/945 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHF 106
            ||.|.|||:|||.||.|||.||||.::.||||.|||:|||||:.:||||:|||||:|||||||||
  Rat     1 MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHF 65

  Fly   107 GQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIA 171
            ||||||||.||.:||||||||||||||||||||||||:|||:|||||.|||||.||||||||.:.
  Rat    66 GQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMG 130

  Fly   172 SPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGV 236
            |.||.||||.|||:|:|:.|:|:||||.|||..|||:||||||:|||||::||:|||||:|.|.|
  Rat   131 SSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSV 195

  Fly   237 TLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLLR 301
            .|:|||||.|.|.|.||:|   |.::||.|||||||||:.||||||||||:|||||||:||||||
  Rat   196 VLLTEMCERSPDMLAHFRK---NEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLR 257

  Fly   302 ILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLN 366
            |||.||.|:|||||||||||||||||||||||.|||||||:||||:||.||||||:|||||||||
  Rat   258 ILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLN 322

  Fly   367 SDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTMTKE 431
            :|||||||||.:||:||..|.:||||||:||::||||.||||:||||||||||:|..|||.|.||
  Rat   323 NDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKE 387

  Fly   432 LLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSP 496
            ||.||:..:.||||.|:||:.||||:|:|:.|||:||.:.||..||:|||||.|.:.|||:::|
  Rat   388 LLYFLDSCEPEFKADCASGVFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNS- 451

  Fly   497 VPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYG-ANEDEFERPTESDLIAVYY 560
            |....|...|.:::: :.::  .:|||:|||.|.|||||||.:.| ..|:|..:.||.:::.:..
  Rat   452 VEMHAYTVQRLYKAI-LGDY--SQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILE 513

  Fly   561 KFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKH 625
            ..|.|...::.::.|||.::.|||||....|..|:.:::.:||.::|:||||.||:..||..|.|
  Rat   514 SVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDH 578

  Fly   626 LRPPLLEKMPAMQ------ISRISSQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTL 684
            :|..|||:||.|:      .|.|...|||:        .|..:|......|....|
  Rat   579 MRSALLERMPVMEKVTTNGPSEIVQTNGET--------EPAPLETKPPPSGPQPTS--------- 626

  Fly   685 GDNTNILLDLLGSTDLSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSA 749
              ..|.||||||..|::.                           |.|               :|
  Rat   627 --QANDLLDLLGGNDITP---------------------------VIP---------------TA 647

  Fly   750 PSSTTTGAPAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASM 814
            |    |..||..||                 .:.::||.:.|.|..:...:.||:|.
  Rat   648 P----TSKPASAGG-----------------ELLDLLGDITLTGAPAAAPTPASVPQ-------- 683

  Fly   815 LGGLGAPPAASPSLAASAPVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQL 879
               :..||.             |:||        |:.....|::.  |..|.:||..|:||.::.
  Rat   684 ---ITQPPF-------------LLDG--------LSSQPLFNDIA--PGIPSITAYSKNGLKIEF 722

  Fly   880 VSVRGSDCMRIYMTTTNNSDNT---LDQYLLQAAVQRSFQLQMLTPSGSVLPP--GGVITQEMRV 939
            ...|.:....:.:.|...|::|   :..::.||||.::||||:|:||.||:|.  .|.|||.::|
  Rat   723 TFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKV 787

  Fly   940 VATSNATLRMRLRIQYVLDGQQQVEQTEVSGFPEQ 974
            :......||||:::.|...|....:..||:.||.|
  Rat   788 LNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQ 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	362/556 (65%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	35/107 (33%)
Ap1g1	NP_001380641.1	Adaptin_N	23..577	CDD:396262	364/560 (65%)
		HEAT repeat	142..163	CDD:293787	13/20 (65%)
		HEAT repeat	175..203	CDD:293787	19/27 (70%)
		HEAT repeat	246..276	CDD:293787	25/29 (86%)
		HEAT repeat	287..319	CDD:293787	26/31 (84%)
		Herpes_BLLF1	<593..>705	CDD:282904	40/227 (18%)
		Alpha_adaptinC2	712..820	CDD:197886	35/107 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H47995
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010