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Protein Alignment AP-1gamma and AP2A2

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001229766.1	Gene:	AP2A2 / 161	HGNCID:	562	Length:	940	Species:	Homo sapiens

Alignment Length:	781	Identity:	204/781 - (26%)
Similarity:	356/781 - (45%)	Gaps:	137/781 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
Human     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65

  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162
            .:||:...||.:|.:.|.:|.|:|:|:||||...:|::...::..||.|.:||||.|.....:||
Human    66 FLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGL 130

  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPATRSL 223
            ||..:.::.|.|||...|.|:.:::.:.:|.  :::.|.||..|:.|..|:|:.:  :......|
Human   131 ALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHL 195

  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286
            |::::.|::....:|||.:.:.:.:   .||..      |...|..|..::....:...|.:  .
Human   196 LNDQHLGVVTAATSLITTLAQKNPE---EFKTS------VSLAVSRLSRIVTSASTDLQDYTYYF 251

  Fly   287 VSDPFLQVKILRLLRILGHNDPDA-----SEAMNDILAQVATNTETSK----NVGNTILYETVLS 342
            |..|:|.||:||||:.....:..|     :|.:..||.:.....::.|    |..|.:|:|.:..
Human   252 VPAPWLSVKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISL 316

  Fly   343 IMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK-DP 404
            |:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..|| :.
Human   317 IIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTER 381

  Fly   405 DVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQ 469
            |||:|:||::|.:|:.:..|...:..|:|.:||.||...:.:....:.:.||:|:....|::||.
Human   382 DVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTI 446

  Fly   470 LSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEY 534
            |:::..||:||.::|....||:|.:.. ..|.|.....:|:|| |..|.:.  |::|..:.:||:
Human   447 LNLIRIAGDYVSEEVWYRVIQIVINRD-DVQGYAAKTVFEALQ-APACHEN--LVKVGGYILGEF 507

  Fly   535 GD----------LFMYGANEDEFER---PTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTR 586
            |:          |..:.....:|..   ||.:.|::.|.||:........:.|..|.|.::|
Human   508 GNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKPTIQDVLRSDSQL--- 569

  Fly   587 LQQCVEEIQALITSFGSHLNVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRIS 643
                            .:.:|:||||.||:        |.:........||..|:..:: ::::.
Human   570 ----------------RNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSI-LAKLK 617

  Fly   644 SQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDL 708
            .:.|.|.....:|...|                                   .|.|:: ||....
Human   618 KKKGPSTVTDLEDTKRD-----------------------------------RSVDVN-GGPEPA 646

  Fly   709 VAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGD 773
            .|:|                  :.||......|||.|..:.|:  ..|.|...||.|.:|.:..|
Human   647 PAST------------------SAVSTPSPSADLLGLGAAPPA--PAGPPPSSGGSGLLVDVFSD 691

  Fly   774 N 774
            :
Human   692 S 692

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.