DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and AP2A1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_011524858.1	Gene:	AP2A1 / 160	HGNCID:	561	Length:	994	Species:	Homo sapiens

Alignment Length:	984	Identity:	243/984 - (24%)
Similarity:	420/984 - (42%)	Gaps:	208/984 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FTEAVERVRMPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKL 94
            ||:..||........:.::::.....::...|...:|||.|.|||.|:.:   |...:.:.:.||
Human    15 FTDLSERAWDLDEVVIVEVLKTCSEGKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKL 79

  Fly    95 LYIHMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFV 159
            |:|.:||:...||.:|.:.|.:|.::|:|:||||...:|::...::..||.|.:||||.|.....
Human    80 LFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTF 144

  Fly   160 VGLALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPAT 220
            :.|||..:..:.|.||....|:::.|::.:.::.  :::.|.||..|:.:..|:|:.:  :....
Human   145 MCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARV 209

  Fly   221 RSLLSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS 285
            ..||::::.|::...|:|||.:|:.:.|..         :..|...|..|..::....:...|.:
Human   210 VHLLNDQHMGVVTAAVSLITCLCKKNPDDF---------KTCVSLAVSRLSRIVSSASTDLQDYT 265

  Fly   286 --GVSDPFLQVKILRLLRILGHNDP-DAS------EAMNDILAQVATNTETSK----NVGNTILY 337
              .|..|:|.||:||||:.  :..| ||:      |.:..:|.:.....::.|    |..|.||:
Human   266 YYFVPAPWLSVKLLRLLQC--YPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILF 328

  Fly   338 ETVLSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILEC 400
            ||:..|:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..
Human   329 ETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINA 393

  Fly   401 LK-DPDVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRW 464
            || :.|||:|:||.:|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|
Human   394 LKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSW 458

  Fly   465 HLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVW 529
            ::||.|:::..||:||.::|....:|:|::.. ..|.|.....:|:|| |..|.:.  :::|..:
Human   459 YVDTILNLIRIAGDYVSEEVWYRVLQIVTNRD-DVQGYAAKTVFEALQ-APACHEN--MVKVGGY 519

  Fly   530 AIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEI 594
            .:||:|:|.   |.:.....|.:..|:  :.||   ...|..::...|.:..|......:....|
Human   520 ILGEFGNLI---AGDPRSSPPVQFSLL--HSKF---HLCSVATRALLLSTYIKFINLFPETKATI 576

  Fly   595 QALITSFGSHL---NVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRISSQNGE 648
            |.::.: ||.|   :|:||||.||:        |.:........||..|:..:: ::::..:.|.
Human   577 QGVLRA-GSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSI-LAKLKRKKGP 639

  Fly   649 SGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATD 713
            ..|.:.||...|...|.:.||       :|...:|
Human   640 GAGSALDDGRRDPSSNDINGG-------MEPTPST------------------------------ 667

  Fly   714 LSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSS 778
                               ||......|||.|..:.|.:    ||....|.|.::..|.|...:.
Human   668 -------------------VSTPSPSADLLGLRAAPPPA----APPASAGAGNLLVDVFDGPAAQ 709

  Fly   779 AANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAASAPVGNLIDGHAG 843
            .:     ||......|.|.|:                     |||....:|
Human   710 PS-----LGPTPEEAFLSELE---------------------PPAPESPMA-------------- 734

  Fly   844 SLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLLQ 908
             ||||..|.|......:.|..|     :.|.||.:.|      |        .|:....:..|||
Human   735 -LLADPAPAADPGPEDIGPPIP-----EADELLNKFV------C--------KNNGVLFENQLLQ 779

  Fly   909 AAVQRSF-----------------QLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYV 956
            ..|:..|                 |.|..:|  :|:.||.:.||  ..|.|.        |:...
Human   780 IGVKSEFRQNLGRMYLFYGNKTSVQFQNFSP--TVVHPGDLQTQ--LAVQTK--------RVAAQ 832

  Fly   957 LDGQQQVEQ 965
            :||..||:|
Human   833 VDGGAQVQQ 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	168/589 (29%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	27/114 (24%)
AP2A1	XP_011524858.1	Adaptin_N	46..608	CDD:279882	168/585 (29%)
		HEAT repeat	349..372	CDD:293787	10/22 (45%)
		HEAT repeat	386..415	CDD:293787	12/28 (43%)
		HEAT repeat	425..451	CDD:293787	7/25 (28%)
		Alpha_adaptinC2	772..875	CDD:197886	21/82 (26%)
		Alpha_adaptin_C	881..989	CDD:280460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820