DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-1gamma and Ap2a2

DIOPT Version :10

Sequence 1:NP_788891.2 Gene:AP-1gamma / 31842 FlyBaseID:FBgn0030089 Length:982 Species:Drosophila melanogaster
Sequence 2:NP_001343997.1 Gene:Ap2a2 / 11772 MGIID:101920 Length:939 Species:Mus musculus


Alignment Length:977 Identity:234/977 - (23%)
Similarity:403/977 - (41%) Gaps:220/977 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
Mouse     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65

  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162
            .:||:...||.:|.:.|.:|.|:|:|:||||...:|::...::..||.|.:||||.|.....:||
Mouse    66 FLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGL 130

  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPATRSL 223
            ||..:..:.|.|||...|.|:.:::.:.:|.  :::.|.||..|:.|..|:|:.:  :......|
Mouse   131 ALHCIANVGSREMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHL 195

  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286
            |::::.|::....:|||.:.:.:.:   .||..      |...|..|..::....:...|.:  .
Mouse   196 LNDQHLGVVTAATSLITTLAQKNPE---EFKTS------VSLAVSRLSRIVTSASTDLQDYTYYF 251

  Fly   287 VSDPFLQVKILRLLRILGHNDPDA-----SEAMNDILAQVATNTETSK----NVGNTILYETVLS 342
            |..|:|.||:||||:.....:..|     :|.:..||.:.....::.|    |..|.:|:|.:..
Mouse   252 VPAPWLSVKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISL 316

  Fly   343 IMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK-DP 404
            |:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..|| :.
Mouse   317 IIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTER 381

  Fly   405 DVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQ 469
            |||:|:||::|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|::||.
Mouse   382 DVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTI 446

  Fly   470 LSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEY 534
            |:::..||:||.::|....||:|.:.. ..|.|.....:|:|| |..|.:.  |::|..:.:||:
Mouse   447 LNLIRIAGDYVSEEVWYRVIQIVINRD-DVQGYAAKTVFEALQ-APACHEN--LVKVGGYILGEF 507

  Fly   535 GD----------LFMYGANEDEFER---PTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTR 586
            |:          |..:.....:|..   ||.:.|::.|.||:........:.|..|.|.::|   
Mouse   508 GNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSDSQL--- 569

  Fly   587 LQQCVEEIQALITSFGSHLNVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRIS 643
                            .:.:|:||||.||:        |.:........||..|:..:: ::::.
Mouse   570 ----------------KNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSI-LAKLK 617

  Fly   644 SQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDL 708
            .:.|.|                                                           
Mouse   618 KKKGPS----------------------------------------------------------- 623

  Fly   709 VAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGD 773
             ..|||.. ..::.|.:.|....||                |:||                    
Mouse   624 -TVTDLEE-TKRERSIDVNGGPEPV----------------PAST-------------------- 650

  Fly   774 NNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAASAPVGNLI 838
                                      |:||.|:...||.    ||||.|.|......|:..|.|:
Mouse   651 --------------------------SAASTPSPSADLL----GLGAVPPAPTGPPPSSGGGLLV 685

  Fly   839 D--GHAGSLLADLNPTAASN--NVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSD 899
            |  ..:.|.:|.|.|.:..|  ..|....|   ...:...|.:.|.|....:..|:::...|.:.
Mouse   686 DVFSDSASAVAPLAPGSEDNFARFVCKNNG---VLFENQLLQIGLKSEFRQNLGRMFIFYGNKTS 747

  Fly   900 ----NTLDQYLLQAAVQRSFQLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYVLDGQ 960
                |.....:....:|.:..|| ..|....:..|..:.|.:.:...|:.|....|.||:...|.
Mouse   748 TQFLNFTPTLICADDLQTNLNLQ-TKPVDPTVDGGAQVQQVVNIECISDFTEAPVLNIQFRYGGT 811

  Fly   961 QQ 962
            .|
Mouse   812 FQ 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-1gammaNP_788891.2 Adaptin_N 68..624 CDD:396262 169/597 (28%)
Alpha_adaptinC2 869..972 CDD:197886 19/98 (19%)
Ap2a2NP_001343997.1 Adaptin_N 29..591 CDD:396262 169/593 (28%)
HEAT repeat 332..355 CDD:293787 10/22 (45%)
HEAT repeat 369..398 CDD:293787 12/28 (43%)
HEAT repeat 408..434 CDD:293787 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..682 25/192 (13%)
Alpha_adaptinC2 717..820 CDD:197886 19/98 (19%)
Alpha_adaptin_C 826..934 CDD:426707
Blue background indicates that the domain is not in the aligned region.

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