DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and Ap4e1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_006498611.1	Gene:	Ap4e1 / 108011	MGIID:	1336993	Length:	1131	Species:	Mus musculus

Alignment Length:	1002	Identity:	228/1002 - (22%)
Similarity:	394/1002 - (39%)	Gaps:	191/1002 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RMPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRN--IAKLLYIHMLGYP 103
            |.|..:||..|||.:.|..:..||..::.:|.:.:::|.....:..:...  :.:|:|..||||.
Mouse    28 RAPFFSRLGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKTMKECMVRLIYCEMLGYD 92

  Fly   104 AHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITN---------CLKNDLNSSTQFV 159
            |.||.:..:||.......:||:|||...|.|.|..::.||:.|         ||..||.|:....
Mouse    93 ASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKTVFFACLWQDLQSTNLVE 157

  Fly   160 VGLALCTLGAIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLL 224
            |.:||..:..|...||...:...:|..::.....||:||.|..::.....|..::......|..|
Mouse   158 VCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHTKFRKAL 222

  Fly   225 SEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSD 289
            .:::.|::...:.:...|.:.::         ||.:::..:.|.|||.::.|....|.....|..
Mouse   223 CDRDVGVMAASLHIYLRMIKENA---------SGYKDLTESFVTILKQVVGGKLPVEFSYHSVPA 278

  Fly   290 PFLQVKILRLLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRV 354
            |:||:::||:|.:||.:|...||.|.|:|.:.....|.:.||...||:|.|.:|..|..:..|..
Mouse   279 PWLQIQLLRILGLLGKDDERTSELMYDVLDESLRRAELNHNVTYAILFECVHTIYSIYPKSELLE 343

  Fly   355 LAVNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFAL 419
            .|...:|:|:|:...|::|:.|..|...:..|.|...:|:.||:|||..||..|:|..:||.:.:
Mouse   344 KAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETLELLYRI 408

  Fly   420 INAQNIRTMTKELLLFLEKADAEFKAQCSSGMIL-AAERYSPTTRWHLDTQLSVLIAAGNYVRDD 483
            .||||:..:.:::|.:|.::..|.......|.|. .||:|:|...|.:.|..:|....|:.:..|
Mouse   409 TNAQNVVVIVQKMLEYLHQSKEEHIIISLVGRIAELAEKYAPDNVWFIQTMNAVFSVGGDVMHPD 473

  Fly   484 VVSSTIQLVSSSPVPE-----------QTYIT-----NRFWESLQVANHCEDKQPLLQVAVWAIG 532
            ::|:.::|::.....|           |:|:|     |.|:           .|..|||..|.:|
Mouse   474 ILSNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENTFY-----------PQRFLQVMSWVLG 527

  Fly   533 EYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQAL 597
            ||..|         .::.:..::|...||.|.|..:|:.:|.:...::.||:.:.... ..::.|
Mouse   528 EYSYL---------LDKESPEEVITRLYKLLMSDSISSETKAWLFAAVTKLTPQAHSS-PLVEKL 582

  Fly   598 ITSFGSHLNVDLQQRGVEFTQLFGHYKHLRPPLLE------------------------------ 632
            |..|...||..|:|...|...|..: ..|...||:
Mouse   583 IQEFTVSLNTCLRQHAFELKHLHEN-TELMKSLLQGAQNCEDIVADASLSFLDGFVAEGLSQGAA 646

  Fly   633 ------KMPAMQISRISSQNGESGGGSFDDN------SPDVIENGVEGGGGGGHSLIESNMNTLG 685
                  :....|:|:....|.|..|.||..:      ||..|..|.:..|....:.::...:...
Mouse   647 PYKPHHQRQEEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDISGNSAETGLKETSSLKM 711

  Fly   686 DNTNILLDLLGSTDLSAGGAGDLVAAT----------DLSNAVHKKNSRNAN------------- 727
            :....|....|.......|.||...|:          ::..|..:|:....:
Mouse   712 EGIKKLWGKEGYLPKKESGTGDKPEASHVPAEGATVENVDQATTRKDQAQGHIPSTEEKEKQLLA 776

  Fly   728 -------------------DVVAPVSNNQDLLDLLDLDL--SAP----SSTTTGAPAGGGGGGGI 767
                               |||:.....:..|.:...|.  |||    |:.:.|:...||...|:
Mouse   777 SSLFVGLGPENTVDLLGKADVVSHKFRRKSKLKVAQSDKTPSAPTAPCSALSLGSDVAGGDEDGL 841

  Fly   768 VAL-VGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAAS 831
            .|: .||...||....:..|.|                                ||:|....:.|
Mouse   842 SAVDRGDGELSSELFRSESLSG--------------------------------PPSAEKLESVS 874

  Fly   832 APVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPR------LTALDKDGLLVQLVSVRGSDCMRI 890
            .||.:|.   |.:.:...||.::|....|..:.|.      :.....:.:.|....|...||:.:
Mouse   875 LPVPSLF---ADNNMEVFNPPSSSATSTVKEETPECRHSGLVEICSNEAVSVSSYKVWRDDCLLV 936

  Fly   891 YMTTTNNSDNTLDQYLLQAAVQRSFQL 917
            ....|:.:|:......|:.....:|::
Mouse   937 IWAVTSKTDSEFTDAQLEIFPVENFKI 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	154/583 (26%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	8/49 (16%)
Ap4e1	XP_006498611.1	Adaptin_N	51..601	CDD:366724	153/579 (26%)
Ap4e1	XP_006498611.1	AP4E_app_platf	1027..1127	CDD:373308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810