DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-1gamma and ap4e1

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_002936390.2	Gene:	ap4e1 / 100494908	XenbaseID:	XB-GENE-988221	Length:	1112	Species:	Xenopus tropicalis

Alignment Length:	1113	Identity:	239/1113 - (21%)
Similarity:	446/1113 - (40%)	Gaps:	251/1113 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TEAVERVRMPTP------------TRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVW 86
            :|.|||.....|            ::|.:|||.|.|..:..||..::.:|.|.::.|....::..
Frog     2 SEIVERTLSALPGLILQDSPSGASSKLGNLIRSITALTSRQEEEKLIQQELANLKVTVSSANTTL 66

  Fly    87 R----CRNIAKLLYIHMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNC 147
            |    |  :.:.:|..||||.:.||.:..:||.......:||:|||...|.|.|..::.||:.|.
Frog    67 RQMKEC--MVRFIYCEMLGYESGFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHENHELLLLLVNT 129

  Fly   148 LKNDLNSSTQFVVGLALCTLGAIASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPEL 212
            :..||.|:....|.:||..:..|...||.......:|..::.....:|:||.|..::.....|..
Frog   130 VLKDLQSTNLVEVCMALTVVSQIFPKEMIPAALPLIEDKLQHSKEIVRRKAVLALYKFYMIAPTQ 194

  Fly   213 MEIFLPATRSLLSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGG 277
            ::......|..|.:::.|::...:.:..::.:::         .:|.:::..:.:.|||.::.|.
Frog   195 VQHIHEKFRKALCDRDVGVMAASLHIYYQVIKDN---------PAGYKDLTGSFITILKQVVGGK 250

  Fly   278 YSPEHDVSGVSDPFLQVKILRLLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLS 342
            ...:.:...|..|:||:::||:||:||.:||.|||.:.|:|.:.....|.:.|:...||:|.|.:
Frog   251 LPADFNYHSVPAPWLQIQLLRILRLLGKDDPRASELIYDVLDESLRRAEINHNITYAILFECVQT 315

  Fly   343 IMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVS 407
            |..|..:..|...|...:|:|:|:...|::|:.|..|...:..|.:...:|:.||:|||..||..
Frog   316 IYTIYPKADLFEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPNLALQHQMTIIECLDHPDPI 380

  Fly   408 IRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILA--------AERYSPTTRW 464
            |:|..:||.:.:.|.||:..:.:::|.:|.::    |.:|:   |:|        ||:|:|..:|
Frog   381 IKRETLELLYRITNGQNVTVIVQKMLDYLTQS----KDECT---IIALVGKIADLAEKYAPNNQW 438

  Fly   465 HLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPE------QTYITNRFWESLQVANHCEDKQPL 523
            .:.|...|....|:.:..|:.::.::|::.....|      :.|....:...|:..| ....|..
Frog   439 FIQTMNVVFSIGGDVIHPDIPNNFLRLLAEGFDDEKEDRQLRLYAVQSYLALLETKN-AHYPQRF 502

  Fly   524 LQVAVWAIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQ 588
            |||..|.:|||..|..:        .|.|| ::...|:.|....|::.:|.:.:.:::||:....
Frog   503 LQVISWVLGEYAYLAKH--------IPVES-VMTNLYEVLKQRSVTSETKAWIVAAISKLTALSP 558

  Fly   589 QCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYKHLRPPLLEKM------------------- 634
            .| ..:..:|..|.:..:..::|...|...|     .:..||..|:
Frog   559 HC-SLVDRIIHEFSTCPDTVMRQHVCELKLL-----RVEGPLTHKLFPLNSSCEDFMVDASLSFL 617

  Fly   635 ----------------PAMQ-----ISRISSQNGESGGGSF----------DDNSPDV--IENGV 666
                            |..|     :||..:.|.:..|..|          |.:||..  :.:|:
Frog   618 DGFVADALSNGAATYIPRHQRQEEKMSREKALNLQPYGLCFSPSLPSASLTDGHSPSAVSVSSGI 682

  Fly   667 EGGGGGGHSLIESNMNTLGDNTNILLD----LLG---------STDLSAGGAGDLVAATD--LSN 716
            .|..|      |:...   ::|.:.||    |.|         ||.:::.....:....|  :|.
Frog   683 SGNSG------ETGQK---EDTRLKLDGVKKLWGKDGYLLKKESTSVTSVKPESMAVPLDSGISQ 738

  Fly   717 AVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQS-SAA 780
            :..||..|....:|......::...|        :||..     .|.|...|:|:|...|: ...
Frog   739 SGDKKLQRTDESLVPFTEEEKEKRQL--------ASTLF-----VGLGSSAVSLMGKAEQTPKKF 790

  Fly   781 NMNNMLGGLDLGGFGSGLDSSASI-------------PTNGNDLAS--------MLGGLGAPPAA 824
            ...:.:||..:..     :.|:|:             ||:|..|.:        .|..||....:
Frog   791 KRKSKIGGNKVMN-----EESSSLPSHLISDGEGYTPPTSGTHLLNSDSHTSPERLDALGEGDVS 850

  Fly   825 S------------PSLAASAPVGNLIDGHAGSLLADL-----NPTAAS----------------N 856
            :            |..:.|...|.....|..|||.||     :|...|                :
Frog   851 TALFANSNMDIIKPLQSTSPNQGTCSVYHVPSLLPDLAQHPHSPVKESASDENLSIYFSKVWKDD 915

  Fly   857 NVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSD-NTLD-----------QYLLQA 909
            ||::     .:..:::..|:.|.:||...|.....::::.:.. :.:|           |.|:..
Frog   916 NVLL-----AIIIVNRTSLVFQNISVHFDDSKNCTISSSLHCQLSQVDALGVQQCWGCVQMLIPC 975

  Fly   910 AVQR-----SFQLQMLTPSGSV----------LPPGGVITQEMRVVATSNAT-LRMRLRIQYVLD 958
            :.:.     |:|.::..|...:          :.|..:.|:|..::..|::. |:.:|.:
Frog   976 SAESVSGCISYQSELAEPCQIIFCVDFLLLDFIRPLSISTEEFGIMWPSHSNELKRKLTV----- 1035

  Fly   959 GQQQVEQT 966
            |||....|
Frog  1036 GQQSFTGT 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	142/573 (25%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	21/126 (17%)
ap4e1	XP_002936390.2	Adaptin_N	44..573	CDD:396262	140/557 (25%)
ap4e1	XP_002936390.2	AP4E_app_platf	1010..1108	CDD:405493	10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010