Protein Alignment AP-1gamma and ap2a1

DIOPT Version :10

• Sequence 1: NP_788891.2
• Gene: AP-1gamma / 31842
• FlyBaseID: FBgn0030089
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_001090846.1
• Gene: ap2a1 / 100038257
• XenbaseID: XB-GENE-923183
• Length: 956
• Species: Xenopus tropicalis
• Alignment Length: 989
• Identity: 242/989 - (24%)
• Similarity: 411/989 - (41%)
• Gaps: 251/989 - (25%)

  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
 Frog     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65

  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162
            .:||:...||.:|.:.|.:|.::|:|:||||...:|::...::..||.|.:||||.|.....:.|
 Frog    66 FLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLIINAIKNDLASRNPTFMCL 130

  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEIFLPATR--SL 223
            ||..:..:.|.|||...|||:.|::.:.:|.  :::.|.||..|:.:..|:|:.:....:|  .|
 Frog   131 ALHCIANVGSREMAEAFASEIPRILVAGDTMDSVKQSAALCLLRLYKTSPDLVPMGEWTSRVVHL 195

  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286
            |::::.|::...|:|||.:|..:.|..         :..|...|..|..::....:...|.:  .
 Frog   196 LNDQHMGVVTAAVSLITCLCRKNPDDF---------KTCVSLAVSRLSRIVSSASTDLQDYTYYF 251

  Fly   287 VSDPFLQVKILRLLRILGHNDP-DAS------EAMNDILAQVATNTETSK----NVGNTILYETV 340
            |..|:|.||:||||:.  :..| ||:      |.:..||.:.....::.|    |..|.||:|.:
 Frog   252 VPAPWLSVKLLRLLQC--YPPPEDAAVKGRLVECLETILNKAQEPPKSKKVQHSNAKNAILFEAI 314

  Fly   341 LSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK- 402
            ..|:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..||
 Frog   315 SLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKT 379

  Fly   403 DPDVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLD 467
            :.|||:|:||.:|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|::|
 Frog   380 ERDVSVRQRAADLLYAMCDRTNAKQIVSEMLSYLETADYSIREEIVLKVAILAEKYAVDYSWYVD 444

  Fly   468 TQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIG 532
            |.|:::..||:||.::|....||:|.:.. ..|.|.....:|:|| |..|.:.  :::|..:.:|
 Frog   445 TILNLIRIAGDYVSEEVWYRVIQIVINRD-DVQGYAAKTVFEALQ-APACHEN--MVKVGGYILG 505

  Fly   533 EYGDLF----------MYGANEDEFER---PTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLS 584
            |:|:|.          .:.....:|..   .|.:.|::.|.||:.....:.|:.|..|.|.:::
 Frog   506 EFGNLIAGDPRSSPLVQFNLLHSKFHLCSVSTRALLLSTYIKFINLFPETKTTIQDVLRSDSQI- 569

  Fly   585 TRLQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFG-HYKHLRPPLLEKMPAMQISRISSQNGE 648
                              .:.:|:||||.||:.:|.. ....:...:||:||
 Frog   570 ------------------RNADVELQQRAVEYLKLSSIASTDVLATVLEEMP------------- 603

  Fly   649 SGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATD 713
                .|.:....::....:..|.|                                     |.:|
 Frog   604 ----PFPERESSILAKLKKKKGPG-------------------------------------AVSD 627

  Fly   714 LSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSS 778
            |......:|| ..|..|.|                .||:.:|.:|:.
 Frog   628 LEEGKKDQNS-EINGGVEP----------------TPSTASTPSPSA------------------ 657

  Fly   779 AANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAASAPVGNLIDGHAG 843
                       ||.|..|...:|::.|:.|:.|..:...   .|.:|..:|..|....|..|.|.
 Frog   658 -----------DLLGLRSTAVTSSAAPSAGSLLVDVFSD---SPTSSVPVAPGAEENFLSSGSAA 708

  Fly   844 SLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLLQ 908
            |                  :.|.|...:.|.||.:.|      |        .|:....:..|||
 Frog   709 S------------------EDPALPIAEADELLNKFV------C--------KNNGVLFENQLLQ 741

  Fly   909 AAVQRSF-----------------QLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQY- 955
            ..|:..|                 |.|..||  :|..||               .|:.::.||.
 Frog   742 IGVKSEFRQNLGRMYLFYGNKTSVQFQSFTP--TVNYPG---------------ELQSQVNIQTK 789

  Fly   956 ----VLDGQQQVEQ 965
                |::|..||:|
 Frog   790 PVDPVVEGGAQVQQ 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:396262	171/592 (29%)
		Alpha_adaptinC2	869..972	CDD:197886	26/119 (22%)
ap2a1	NP_001090846.1	Adaptin_N	29..591	CDD:396262	172/595 (29%)
		HEAT repeat	332..355	CDD:293787	10/22 (45%)
		HEAT repeat	369..398	CDD:293787	12/28 (43%)
		HEAT repeat	408..434	CDD:293787	7/25 (28%)
		Alpha_adaptinC2	734..837	CDD:197886	20/87 (23%)
		Alpha_adaptin_C	843..951	CDD:426707