DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1gamma and ap1g2

DIOPT Version :9

Sequence 1:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001276787.1	Gene:	ap1g2 / 100007877	ZFINID:	ZDB-GENE-030616-587	Length:	794	Species:	Danio rerio

Alignment Length:	947	Identity:	399/947 - (42%)
Similarity:	563/947 - (59%)	Gaps:	171/947 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TPT-RLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHFG 107
            ||: ||:::||.||:|||..|||.::.||||.||:.||:.|:..|..::|||||:||||||||||
Zfish     2 TPSVRLQEMIRVIRSARTQGEERGIIQKECAEIRAQFRQTDNGERSHSLAKLLYVHMLGYPAHFG 66

  Fly   108 QLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIAS 172
            |:||::|.||.|:::|||||||||:||||:||..|||||.:||||:.|:|:|..||||||..:.|
Zfish    67 QMECVRLIASPRYSEKRIGYLGAMMLLDEKQDASLLITNSIKNDLSHSSQYVQSLALCTLACMGS 131

  Fly   173 PEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILITGVT 237
            .||.||||.|:|||:::..:||:|||||||..:||:||||.|:|.|:.||||||||||:|...|.
Zfish   132 SEMCRDLAPEIERLLRASTSYIKKKATLCAVHIIRKVPELAELFTPSARSLLSEKNHGVLHGAVV 196

  Fly   238 LITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFLQVKILRLLRI 302
            ||||:||.:::||..|:|      .||.||.|:|.|:...|||||:|:|:|||||||:|||||||
Zfish   197 LITELCERNAETLDKFRK------AVPELVTIMKGLVTSSYSPEHNVAGISDPFLQVRILRLLRI 255

  Fly   303 LGHNDPDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLNS 367
            ||||:..||:||||:||||||||::||..|:.:||||||:||||.||.||||||||||||||||:
Zfish   256 LGHNNDSASDAMNDLLAQVATNTDSSKTAGSAVLYETVLTIMDINSESGLRVLAVNILGRFLLNN 320

  Fly   368 DKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINAQNIRTMTKEL 432
            |:||||:::.:|.:.|..|.:||||||.||::||||.|.|::|||:|||.||::..|||:|.|||
Zfish   321 DRNIRYISMTSLQKIVQTDHNAVQRHRGTIVDCLKDQDTSVKRRALELSLALVSPVNIRSMMKEL 385

  Fly   433 LLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPV 497
            |:||.....|.::|.:||:..|||||||:.|||:||.|.||..||..|||:.|.:.|||::::.
Zfish   386 LIFLSSCPVELRSQTASGIFNAAERYSPSKRWHIDTILHVLTTAGGDVRDETVPNLIQLITTAS- 449

  Fly   498 PEQTYITNRFWESLQVANHCED--KQPLLQVAVWAIGEYGDLFMYGANED-EFERPTESDLIAVY 559
            ....|..::.:.:|     .:|  :|.|:|||.|.|||||||.:.|..|: |..:.||.|::...
Zfish   450 ELHCYTVHKLYRAL-----VKDISQQSLVQVACWCIGEYGDLLLKGECEEIEPVQVTEDDVLDAL 509

  Fly   560 YKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITSFGSHLNVDLQQRGVEFTQLFGHYK 624
            ...|.|...:..::.:||.:..|||||:...|:.|:::::.:||.::::||||.||:..||..|.
Zfish   510 ETVLQSHMSAPATRGFALTATMKLSTRITDNVDRIRSIVSIYGSCIDLELQQRAVEYNALFKKYD 574

  Fly   625 HLRPPLLEKMPAMQISRISSQNGESGGGSFDDNSPDVIE-NGVEGGGGGGHSLIESNMNTLGDNT 688
            |:|..:||:||.|:.:.....||:|.|   :...|:..: ..||      ..|:....|.:.|
Zfish   575 HMRAAVLERMPLMEKNSPGHTNGDSSG---EIKEPEPAKTKPVE------PILLSEPANQVCD-- 628

  Fly   689 NILLDLLGSTDLSAGGAGDLVAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSST 753
              ||||||.||                               .||..:           |||:||
Zfish   629 --LLDLLGGTD-------------------------------TPVQPS-----------SAPTST 649

  Fly   754 TTGAPAGGGGGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGL 818
            .|                    .:|:|::.::||||:              ||
Zfish   650 AT--------------------TTSSADLLDLLGGLE--------------PT------------ 668

  Fly   819 GAPPAASPSLAASAPVGNLIDGHAGSLLADLNPTAASNNVVVPPQGPRLTALDKDG--LLVQLVS 881
                          ||                              |.:|..:|:|  |.:|..|
Zfish   669 --------------PV------------------------------PAVTVYEKNGVSLKIQCDS 689

  Fly   882 VRGSDCMRIYMTTTNNSDNTLDQYLLQAAVQRSFQLQMLTPSGSVLPPGGV--ITQEMRVVATSN 944
            ...:| :.:.:..:|::.|.:..:.|||||.:|.||||..|||:|:...|:  :||.:.:...:.
Zfish   690 QTDTD-ITVTLIASNSTQNDISNFTLQAAVPKSVQLQMKAPSGNVIAAHGLGQVTQTVLLNNPNK 753

  Fly   945 ATLRMRLRIQYVLDGQQQVEQTEVSGFP----EQQPA 977
            .:|:||:|:.|...|....:..::..||    ..||:
Zfish   754 VSLKMRVRVSYSDQGTMLQDTVQIDSFPSPSWNSQPS 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	304/558 (54%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886	31/106 (29%)
ap1g2	NP_001276787.1	Adaptin_N	23..574	CDD:279882	306/562 (54%)
ap1g2	NP_001276787.1	Alpha_adaptinC2	675..781	CDD:197886	31/106 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590485
Domainoid	1	1.000	705	1.000	Domainoid score	I122
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	804	1.000	Inparanoid score	I471
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D250202at2759
OrthoFinder	1	1.000	-	-		FOG0002071
OrthoInspector	1	1.000	-	-		otm26293
orthoMCL	1	0.900	-	-		OOG6_101228
Panther	1	1.100	-	-	O	PTHR22780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1368
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910