DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bx42 and skp-1

DIOPT Version :9

Sequence 1:	NP_001259370.1	Gene:	Bx42 / 31840	FlyBaseID:	FBgn0004856	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_505950.1	Gene:	skp-1 / 179598	WormBaseID:	WBGene00004806	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	293/557 - (52%)
Similarity:	382/557 - (68%)	Gaps:	34/557 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLSSLLPTPTNAIWDREDERRLVARGAPKIG--------ALVSAKIAAPPYGQRKDWVPHTDAD 57
            |.|..:||.|..|     ||.....|..|..|        ||||.:  .||||:|..:.|....|
Worm     3 MKLRDILPAPVAA-----DEAASQIRRDPWFGGRDNEPSAALVSKE--PPPYGKRTSFRPRGPED 60

  Fly    58 FGDGGAFPEIHVAQYPLGLGAPGNVGKKSDALAVRLDDKGKVKYDAIARQGHGKDKIVYSSISQL 122
            ||||||||||||||:|||||.....||..:.||::....||:::|||||.||.|||:|||.::.
Worm    61 FGDGGAFPEIHVAQFPLGLGLGDMRGKPENTLALQYGTDGKLQHDAIARIGHVKDKVVYSKLND- 124

  Fly   123 LPAEVLAEDADELQRPDEETVMETTEETRLALEKLTNQKITSALPVRHAQKAGPAQYIRYTPSQQ 187
            :.|:...||.|::|:||::.|::.||:||:||||:.|.|:.||||||||.|..||||||||||||
Worm   125 MKAKTWNEDDDDIQKPDDDAVIDATEKTRMALEKIVNSKVASALPVRHADKLAPAQYIRYTPSQQ 189

  Fly   188 GDTFNSGAKQRVIRMVEAQLDPMEPPKFRINKKIPRGPPSPPAPVLHSPSRKVTVKEQKEWKIPP 252
            ...  :|::||:|||||.|.||||||||:||:||||.||||||||:|||.||:|.|:|.:|||||
Worm   190 NGA--AGSQQRIIRMVEEQKDPMEPPKFKINQKIPRAPPSPPAPVMHSPPRKMTAKDQNDWKIPP 252

  Fly   253 CISNWKNAKGYTIPLDKRLAADGRGLQQVHINEKFAKMAEALYIADRKAREAVEARSQLEKKLAQ 317
            |||||||.||:|:.||||||||||||||.||||.|||:|:|||||||||||.||.|:|||:::||
Worm   253 CISNWKNPKGFTVGLDKRLAADGRGLQQTHINENFAKLADALYIADRKAREEVETRAQLERRVAQ 317

  Fly   318 KEKEKKEDMLRMMAQRAREERAGLRNPEAAEPSGSGATGSEVRERNDLRAERQRERQRDRNLQRA 382
            .:|.::|..:...|.:||:||:.:|..:..:       ..:|:.|.::|.:|..:.:::||:.|:
Worm   318 NKKSEQEAKMAEAAAKARQERSAMRRKDDED-------DEQVKVREEIRRDRLDDIRKERNIARS 375

  Fly   383 APEKRSKLQKERERDISEQIALGLP-AKSAGNGETLFDQRLFNTTKGMDSGYGDDEAYNVYDKPW 446
            .|:|..||:|||||||||:|.|||| ......||..||||||:.|:|:|||..||:.||.||..|
Worm   376 RPDKADKLRKERERDISEKIVLGLPDTNQKRTGEPQFDQRLFDKTQGLDSGAMDDDTYNPYDAAW 440

  Fly   447 RDSNTLGAHIYRPSKQADSDNYGGDLDAIVNTK-RFVPDKQFSGASKEAAAGQRSGPVEFEKEED 510
            |..:::..|:|||||..|:|.||||||.|:..| |||.||.||||.   .:.:.||||:|||::|
Worm   441 RGGDSVQQHVYRPSKNLDNDVYGGDLDKIIEQKNRFVADKGFSGAE---GSSRGSGPVQFEKDQD 502

  Fly   511 PFGLDQFLNMAKKAPKRAEEKNNERSSHSDRKRSKRD 547
            .|||.......|: .||..:..:.|   .:.|||:||
Worm   503 VFGLSSLFEHTKE-KKRGGDGGDSR---GESKRSRRD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx42	NP_001259370.1	SKIP_SNW	181..337	CDD:280827	107/155 (69%)
skp-1	NP_505950.1	SKIP_SNW	183..323	CDD:280827	103/141 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166985
Domainoid	1	1.000	239	1.000	Domainoid score	I1273
eggNOG	1	0.900	-	-		E1_KOG2441
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56557
Inparanoid	1	1.050	554	1.000	Inparanoid score	I606
Isobase	1	0.950	-	0	Normalized mean entropy	S1868
OMA	1	1.010	-	-		QHG55207
OrthoDB	1	1.010	-	-		D1455730at2759
OrthoFinder	1	1.000	-	-		FOG0005122
OrthoInspector	1	1.000	-	-		oto18512
orthoMCL	1	0.900	-	-		OOG6_102543
Panther	1	1.100	-	-	LDO	PTHR12096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R994
SonicParanoid	1	1.000	-	-		X3642
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790