DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HNRNPD and sqd

DIOPT Version :9

Sequence 1:	NP_112738.1	Gene:	HNRNPD / 3184	HGNCID:	5036	Length:	355	Species:	Homo sapiens
Sequence 2:	NP_731825.1	Gene:	sqd / 41666	FlyBaseID:	FBgn0263396	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	124/306 - (40%)
Similarity:	177/306 - (57%)	Gaps:	31/306 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    51 TASG-GTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQR-EEWKMFIGGLSWDTTKKDL 113
            ||.| |:|.|.|.:.|:             :|.|..:..||:.|| ::.|:|:|||||:||:|:|
  Fly    21 TADGPGSENGDAGAAGS-------------TNGSSDNQSAASGQRDDDRKLFVGGLSWETTEKEL 72

Human   114 KDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTK 178
            :|:|.|:||:....:|.||.|||||||.|::|..:|::|||....||.:|.|.:|||:|||..
  Fly    73 RDHFGKYGEIESINVKTDPQTGRSRGFAFIVFTNTEAIDKVSAADEHIINSKKVDPKKAKARH-- 135

Human   179 EPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKK 243
               .|||||||:.:..:|:|:.|||.||.:..:|:|.|.:.::|:|||||||..|:.|..:::..
  Fly   136 ---GKIFVGGLTTEISDEEIKTYFGQFGNIVEVEMPFDKQKSQRKGFCFITFDSEQVVTDLLKTP 197

Human   244 YHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYN 308
            ...:...:.::|.|..|.  :.|...|.|||..|..||..||  .....||:|.|: |.|:||
  Fly   198 KQKIAGKEVDVKRATPKP--ENQMMGGMRGGPRGGMRGGRGG--YGGRGGYNNQWD-GQGSYG-- 255

Human   309 SQGY-GGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQ-NSY 352
              || ||||||...||.:||..|.|:....||......||.: |.|
  Fly   256 --GYGGGYGGYGAGGYGDYYAGGYYNGYDYGYDGYGYGGGFEGNGY 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPD	NP_112738.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		12/41 (29%)
		CBFNT	<60..78	CDD:311868	2/17 (12%)
		RRM1_hnRNPD	99..172	CDD:410150	38/72 (53%)
		RRM2_hnRNPD	183..257	CDD:241027	28/73 (38%)
sqd	NP_731825.1	RRM_SF	58..129	CDD:302621	36/70 (51%)
sqd	NP_731825.1	RRM2_hnRNPD_like	137..211	CDD:240775	28/73 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3498
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45859
OrthoDB	1	1.010	-	-		D1055256at2759
OrthoFinder	1	1.000	-	-		FOG0001417
OrthoInspector	1	1.000	-	-		oto91036
orthoMCL	1	0.900	-	-		OOG6_112757
Panther	1	1.100	-	-	O	PTHR48033
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X985
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.940