DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7766 and Phka2

DIOPT Version :9

Sequence 1:	NP_001245588.1	Gene:	CG7766 / 31839	FlyBaseID:	FBgn0030087	Length:	1358	Species:	Drosophila melanogaster
Sequence 2:	NP_001382568.1	Gene:	Phka2 / 678739	RGDID:	1596945	Length:	1217	Species:	Rattus norvegicus

Alignment Length:	1427	Identity:	642/1427 - (44%)
Similarity:	829/1427 - (58%)	Gaps:	290/1427 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIA 65
            ||||||||||||.|.|:|.:.||.:|.|||||..||:....||:|||:|.|||||||.|||:|.|
  Rat     1 MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHDQKDAWVRDNIYSILAVWGLGMAYRKNA 65

  Fly    66 DQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEW 130
            |:|||:||.|||||:.||||||||..||.|.|||||||.|||..|||||||::.....||.|::|
  Rat    66 DRDEDKAKAYELEQNVVKLMRGLLQCMMRQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQW 130

  Fly   131 GHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEP 195
            ||||:||.||:||.|||||||||:|:|:||||:||||||||||:||.:.|||:||||||||.|.|
  Rat   131 GHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195

  Fly   196 ELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLL 260
            ||||||:|||||||||::|||||||.||..||||||.||...||::|.|||||.|.|||:|:|||
  Rat   196 ELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLL 260

  Fly   261 CVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIE 325
            .:|.||||||:|..|::.||:.|:|:|||:|||.|||||||:||:|||.||:|:..||::|||||
  Rat   261 SIISFPAFAVEDVHLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPHRLHYDPAELKLFENIE 325

  Fly   326 CEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQ 390
            ||||:|:.|||:...|..|...|:||...||.|::|.:|||.||||.||:|.|.|..||:.|.:.
  Rat   326 CEWPVFWTYLIIDGVFNGDAVQVQEYREALEGILIRGKDGIHLVPELYAIPPDKVDEEYKNPHTV 390

  Fly   391 VREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKL 455
            .|..:|:.|.||||||:||..||.|||||.||:||||||.....||||||||.::||::.|:..|
  Rat   391 DRIPLGKLPHLWGQSLYILSSLLAEGFLATGEIDPLNRRFSTSVKPDVVVQVAVLAENSHIKGLL 455

  Fly   456 AEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAF 520
            .:|.::||:||:|.||.|||.|:|||:|..||:|:.:.||||..|.:|:|.|||||.:::.||.|
  Rat   456 KQHGINVQSIADVHPIRVQPGRILSHIYAKLGQNKNMKLSGRPYRHIGVLGTSKLYVIRNHIFTF 520

  Fly   521 TPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYMLDQD--KIPLAMIQ 583
            |||..|...:|...|.:::.......||:|...|| |.||||:|...||.||..|  .|..|::.
  Rat   521 TPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWR-MTGRPTLTFPVTHTMLTNDGSDIHPAVLS 584

  Fly   584 TMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFL---------GSTED------------GY-P 626
            |:|||:.||..|.||.||.|.:||.||..|.|:||         |...|            || .
  Rat   585 TIRKLEDGYFGGARVKLGILAEFLTTSFYTYLTFLDPDCDEKLFGDISDRSFSPDSESDLGGYLE 649

  Fly   627 DRLHPDVQTYLDE---HLLRSFSNRSTMNLRGGQLRPRTLRRRMSCK--------GAIKKTRSI- 679
            |..|.:.|..||:   |||:|.|.:.       .|.|       .||        .|:..||.|
  Rat   650 DSSHQESQDELDQYISHLLQSTSLKC-------YLPP-------LCKKSEDSHVFSAVHSTRDIL 700

  Fly   680 NVDSDNLGMEGP-SPLTERRLSSIVPPPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENI 743
            :|.:...|:|.| .|:       |:|...|..:::|                 |:|
  Rat   701 SVMAKAKGLETPFFPM-------ILPTRVLSGHRKS-----------------LNL--------- 732

  Fly   744 YPVDPHHSRSAIDRRSEFVRQQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGDIL 808
                       :|....|:::    .|:...|..|.:.:  :.:.|:|:..|::..||::|.|||
  Rat   733 -----------VDSPQPFLKK----TPEYDYQWPRDDQD--EVDCEKLVGQLKDCSNLQDQADIL 780

  Fly   809 QYLVDTQGLDFNTAGLGFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDGAK 873
            ..|...:|..::|...|
  Rat   781 YILYVIKGPRWDTNLFG------------------------------------------------ 797

  Fly   874 KSPTIVLPTVIIDAATIPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNMSP 938

  Rat   798 ----------------------------------------------------------------- 797

  Fly   939 HENNHDSSQSEGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDLLV 1003
                          :.|  |||..||..||.||...:.|.|:|:.:|:|.|:||.||:|..|||.
  Rat   798 --------------QHG--VTVHSLLGELYGKAGLNQEWSLIRYISGLLRKKVEVLAEACADLLS 846

  Fly  1004 RQKQVTVGMPPN-NEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLFHE 1067
            .|||:|||:||. .|.||:.|||..||.:||::|.|.|.|.|:||||::|||||::|.:|.||.|
  Rat   847 HQKQLTVGLPPEPREKTISTPLPPEELTELIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFAE 911

  Fly  1068 MLRLRVGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEFAV--------SS 1124
            |||||:||||||||.||:|:|||.||.|||.|:|||||:||:||:||||||||.|        ||
  Rat   912 MLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKSLLHHILSGKEFGVERSVRPIHSS 976

  Fly  1125 VARGNLSIVSCKSSRVSKKSQIGLGDPEGEDALI---ATID------------------------ 1162
            ::...:||.....:.|:|..:.|:.....|...:   |:.|
  Rat   977 MSSPAISIHEVGHTGVTKTERSGISRLRSEMKQMNRRASADEQRSSTPSSPTGTSSTDSGGHHLG 1041

  Fly  1163 --DRQGQWLRRRRLDGALNRVPRDFYSRVWTVLEKCQGLAIEGRVLQQSLTQEMTPGELKFALEV 1225
              ::|||||||||||||:||||..||.|||.:|:||.||:|:|.||..|.||||||.|:|||:.|
  Rat  1042 WGEQQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSIDGYVLPSSTTQEMTPCEIKFAVHV 1106

  Fly  1226 ETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPSLGGVIYVEHLVHKANQLFLEDQRKVQGDATL 1290
            |:.||::.|||||||:|||:|||||:::..| .|:||:|:|:.:|..||||||:||  |....|
  Rat  1107 ESVLNRVSQPEYRQLLVEAIMVLTLLSDTEM-DSIGGIIHVDQIVQLANQLFLQDQ--VSFGTT- 1167

  Fly  1291 CCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSRAVALVL-DCVPKHG 1351
                  |..|:.||..          ||...|||||||:||||||:::|||..| |.:|..|
  Rat  1168 ------DILEKDQATG----------ICHLFYDSAPSGAYGTMTYLTKAVASHLQDLLPSSG 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:279112	279/430 (65%)
CG7766	NP_001245588.1	Glyco_hydro_15	<959..1075	CDD:279112	64/116 (55%)
Phka2	NP_001382568.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H246
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910