DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7766 and phkb

DIOPT Version :9

Sequence 1:	NP_001245588.1	Gene:	CG7766 / 31839	FlyBaseID:	FBgn0030087	Length:	1358	Species:	Drosophila melanogaster
Sequence 2:	XP_005166459.1	Gene:	phkb / 569706	ZFINID:	ZDB-GENE-110411-149	Length:	1087	Species:	Danio rerio

Alignment Length:	1386	Identity:	400/1386 - (28%)
Similarity:	625/1386 - (45%)	Gaps:	378/1386 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLDYYQRIVHRLILAHQEPVTGLFPASNVNS--HAWIRDNVYCILAVWGLSMAYKKIADQDEDRA 72
            :||.:...|...||.:|.|.|||||....::  .|.:||::||..::|.|::||::|   |:|..
Zfish    43 KLDRFYSAVKSTILNYQSPTTGLFPVKTCSTCKEAKVRDSLYCAASIWALALAYRRI---DDDMG 104

  Fly    73 KCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEWGHLQIDA 137
            :.:|||.|.:|.|||::...|.|.||||.||...||...||:.::...|..|....|:.||||||
Zfish   105 RTHELEHSAIKCMRGIMYCYMRQSDKVENFKQDPSPSTCLHSIFNVDTGDEVYPYKEYNHLQIDA 169

  Fly   138 VSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEPELNASSI 202
            :||:||.|.:|..|||||:::.|||||||||||.:|.||.:||:|:||||.|.|:|..||::||:
Zfish   170 LSLFLLYLVEMICSGLQIIYNTDEVSFIQNLVFCVERAYRVPDFGMWERGSKYNNGSTELHSSSV 234

  Fly   203 GMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLLCVIGFPA 267
            |:|||||||:|..:|||.:|...|||.|..|..::.:..|.|:|||||.|...||.||..|.:||
Zfish   235 GLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNTDSALLPCISYPA 299

  Fly   268 FAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIECEWPLFY 332
            |||||..|...|.|.|:.:|:||||.|||||||:||..||.:|.:|:..|:::|:.||||:|:||
Zfish   300 FAVDDDALYSQTLDKIVRKLKGKYGFKRFLRDGFRTANEDKNRRHYKPAEMKLFDGIECEFPIFY 364

  Fly   333 CYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQVR--EVV 395
            .|:::...|:.:...|:||...|:.::.:|.:|..::|:.|.||.|.|..|.:|.|||.|  ...
Zfish   365 IYMMIDGVFRGNPDQVKEYQELLQAVIFQSFEGHAVIPKYYHVPADFVEAEQKKHGSQKRFPSNS 429

  Fly   396 GR--CPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQK--------------KPDVVVQVVI 444
            ||  ..|||||:|:.:.:||.:|.::..::||::|.:..|.              :.|||:.|.:
Zfish   430 GRDGMLFLWGQALYNIAKLLVDGLISPKDIDPIHRYVPRQDQRNVSMRYSNQGPIENDVVIHVAL 494

  Fly   445 IAEDNEIRDKLAEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSK 509
            |||...::..|..:.:..||..:|.||::.|.:.|...|.:|..|:|||||||..|.||.:.|.|
Zfish   495 IAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQKELVKAYRFLAVNKKLGLSGRPERPVGCIGTCK 559

  Fly   510 LYSLKDRIFAFTPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYMLDQ 574
            :|.:..:.....|...|..::|.::|..||..:....|.|:...|: |.|||...:     ::.:
Zfish   560 IYRILGKTVVCYPIVFDLSDFYLSQDVMLLIDDIKNALQFIKQCWK-MPGRPLFLV-----LIRE 618

  Fly   575 DKI------PLAMIQTMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFLGSTEDGYPDRLHPDV 633
            |.|      |:  :..:...|.|.|.|.:|.:..|:..::.:.:..|.||...|...|:
Zfish   619 DNIKGSRFNPI--LDMLASFKKGNIGGVKVHVDRLQTLISGAVVEQLDFLRVNEAEIPE------ 675

  Fly   634 QTYLDEHLLRSFSNRSTMNLRGGQLRPRTLRRRMSCKGAIKKTRSINVDSDNLGMEGPSPLTERR 698
                    .:||
Zfish   676 --------FKSF----------------------------------------------------- 679

  Fly   699 LSSIVPPPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENIYPVDPHHSRSAIDRRSEFVR 763
                                     ||      |.|             |.||:
Zfish   680 -------------------------EE------LEL-------------PKHSK----------- 689

  Fly   764 QQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGDILQYLVDTQGLDFNTAGLGFKN 828
                      ::|..:..|.:|               ||:|.:|
Zfish   690 ----------VKRQTSTPNASD---------------LEQQPEI--------------------- 708

  Fly   829 KSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDGAKKSPTIVLPTVIIDAATIPAG 893
              .:....|.:..|:.|.|
Zfish   709 --NDEEWFNKSTFEILQKF---------------------------------------------- 725

  Fly   894 TGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNMSPHENNHDSSQSEGMLEEGRVV 958
                              |:..|:.:.:.::|...........:.:||
Zfish   726 ------------------NDCDCLASQAQLASILLKKEGPEFFNTNEN----------------- 755

  Fly   959 TVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDLLVRQKQVTVGMPPNNEHTITAP 1023
             ::|.|:.:|.:|..:|||.:||..|.:|.|.|:.||.::|.:||..||||:|:..:.|..|:.|
Zfish   756 -LKDELERIYRRAGSRKLWSVVRLAASLLTKLVDSLAPSITSVLVHGKQVTLGLFGHEEIVISNP 819

  Fly  1024 LPEVELRQLIH---DAYGDDESTAMLTQELMVYLAMFIRTEPQLFHEMLRLRVGLIIQVMAKELS 1085
            |....::.:|:   ..:|:.|  |:|.|||::::...|...|:||..||::|||.|:|.|..||.
Zfish   820 LSPGVIKDIIYSKCSPHGERE--AVLQQELVIHIGWIISNNPELFSGMLKIRVGWIVQAMKHELK 882

  Fly  1086 RTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEFAVSSVARGNLSIVSCKSSRVSKKSQIGLGD 1150
            ...   |:...:.:..:||.::|.||..:|..::                 |.|
Zfish   883 IRA---GDMPPQDIYQMSPSDVKQLLLDVLQSQQ-----------------SGR----------- 916

  Fly  1151 PEGEDALIATIDDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLEKCQ-GLAIEGRVL-QQSLTQE 1213
                            .||.||::||:|||.|..||.|||.:||:.: |:.:.|:.| ||....:
Zfish   917 ----------------SWLNRRQIDGSLNRTPLGFYDRVWQILERTRNGIMVGGKHLPQQPTLSD 965

  Fly  1214 MTPGELKFALEVETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPSLGGVIYVEHLVHKANQLFL 1278
            ||..|:.|:|.||..|..|..|||||::||.|||:::|.|.|........:.::.||.:|...|.
Zfish   966 MTMYEMNFSLLVEDTLKNIVLPEYRQIIVELLMVVSIVLERNPELEFQEPVDLDKLVKEAFADFQ 1030

  Fly  1279 EDQRKVQGDATLCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSRAVALV 1343
            :|:.|::|         .:.::..:|                .|::...|...|.:|:::||.:.
Zfish  1031 KDRSKLEG---------TEKRDTMEA----------------FYNTPALGKQSTSSYLTKAVMIQ 1070

  Fly  1344 LDCVPKHGEME------CAIS 1358
            |    ..||::      |::|
Zfish  1071 L----LQGEVKPSKDDPCSVS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:279112	197/448 (44%)
CG7766	NP_001245588.1	Glyco_hydro_15	<959..1075	CDD:279112	43/118 (36%)
phkb	XP_005166459.1	Glyco_hydro_15	44..>465	CDD:279112	194/423 (46%)
phkb	XP_005166459.1	Glyco_hydro_15	<745..872	CDD:279112	45/146 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720