DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7766 and phka2

DIOPT Version :9

Sequence 1:	NP_001245588.1	Gene:	CG7766 / 31839	FlyBaseID:	FBgn0030087	Length:	1358	Species:	Drosophila melanogaster
Sequence 2:	XP_021335546.1	Gene:	phka2 / 556199	ZFINID:	ZDB-GENE-130422-1	Length:	1224	Species:	Danio rerio

Alignment Length:	1425	Identity:	634/1425 - (44%)
Similarity:	803/1425 - (56%)	Gaps:	285/1425 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIA 65
            ||||||||||||.:.|:||..||.||.|||||.|||.....||:|||||.|||||||.|||:|.|
Zfish     1 MRSRSNSGVRLDGFARLVHETILCHQNPVTGLLPASEQQKDAWVRDNVYSILAVWGLGMAYRKNA 65

  Fly    66 DQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEW 130
            |:|||:||.||||||.||||:|||..||.|.:||||||.|||..|.|||||.:.....||.|::|
Zfish    66 DRDEDKAKAYELEQSVVKLMQGLLQCMMRQVEKVEKFKHTQSTKDCLHAKYHTPTCATVVGDDQW 130

  Fly   131 GHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEP 195
            ||||:||.|||||.|||||||||.|:.:||||:||||||||||:||.:.|||:||||||||.|.|
Zfish   131 GHLQVDATSLYLLTLAQMTASGLHIISNLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195

  Fly   196 ELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLL 260
            |||.||:|||||||||::|||||||.|||.||||||.||...||::|.|||||.|.|||:|:|||
Zfish   196 ELNGSSVGMAKAALEAIDELDLFGAHGGPKSVIHVLPDEVEHCQSILCSMLPRASTSKEIDAGLL 260

  Fly   261 CVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIE 325
            .||.||||||:||.|::.||..|:::|||:|||.||:|||||||||||:||:|:..||::|||||
Zfish   261 SVISFPAFAVEDADLVNITKAEIITKLQGRYGCCRFIRDGYRTPKEDPTRLHYDPAELKLFENIE 325

  Fly   326 CEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQ 390
            ||||:|:.||||...|.:|...||||...|:.:::|.:.||.||||.||||.|.|..||:.|.|.
Zfish   326 CEWPVFWTYLILDGIFNADHEQVEEYREALDGVLIRGKHGIRLVPELYAVPADKVEEEYRNPHSV 390

  Fly   391 VREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKL 455
            .|...|:.|.:|||||:|||.||.|||||.||:||||||...:.||||||||.::||..:|:..|
Zfish   391 ERVAFGQLPHMWGQSLYILGSLLTEGFLAPGEIDPLNRRFSKEFKPDVVVQVSVVAESVQIQQLL 455

  Fly   456 AEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAF 520
            .:|.:.|||:::|:||.|.|||:|||:|..||..:||.||||..|.:|:|.|||.|.:::..:.|
Zfish   456 RDHGIEVQTVSDVSPIRVMPARILSHIYVKLGNCKKLNLSGRPYRHIGVLGTSKFYEIRNGTYTF 520

  Fly   521 TPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYML--DQDKIPLAMIQ 583
            |||.||...:|...|..::.....|.||:|::.|| |.||||:|...|..||  |.|.|...::.
Zfish   521 TPQFIDQHHFYLALDNQMIVEMLRTELAYLSSCWR-MTGRPTLTFPITQSMLVEDGDSIDPCILS 584

  Fly   584 TMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFL--GSTEDGYPDRLHPDVQT----------- 635
            |:|||:.||..|.||.:.:|..||.||..|.||||  .|.||...:....|.:.
Zfish   585 TLRKLQDGYFGGARVQMANLSSFLTTSFHTQLSFLDGDSEEDLLEEEEEEDEEASAGGSGDMFDQ 649

  Fly   636 YLDEHLLRSFSNRSTMNLRGGQLRPRTLRRRMSCKGAIKKTRSI-----NVDSDNLGMEGPSPLT 695
            ||.: ||.|.:.:..:        |...|.:.....|...||.|     .|...|:    |.|
Zfish   650 YLTD-LLHSTTTKCHL--------PPIQRGQHHVFSAEHTTRDILSFMAQVQGHNM----PKP-- 699

  Fly   696 ERRLSSIVP-PPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENIYPVDPHHSRSAIDRRS 759
                |..:| .|.:..:::|                          .|:..| |.|..|...:..
Zfish   700 ----SMYLPVAPIMSKHRKS--------------------------LNLLDV-PQHKASPQTKAD 733

  Fly   760 EFVRQQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGDILQYLVDTQGLDFNTAGL 824
            .             :..|....:..:|:...|:..|:....|::|.|||..|.
Zfish   734 N-------------VDLHLPRDSHGNTDFVHLVDQLKHCPTLQDQADILYVLY------------ 773

  Fly   825 GFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDGAKKSPTIVLPTVIIDAAT 889
                                                           |.|.|..|:..
Zfish   774 -----------------------------------------------AMKGPNWVVSL------- 784

  Fly   890 IPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNMSPHENNHDSSQSEGMLEE 954
                                                                   |.|.|
Zfish   785 -------------------------------------------------------SGQGE----- 789

  Fly   955 GRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDLLVRQKQVTVGMPPN-NEH 1018
               .|||.||:.||.:|...|.|||:|:.:|:|.||||.||:|.|||:...||:|||:||. .|.
Zfish   790 ---ATVRSLLEELYVRAGACKEWGLIRYISGILKKRVEVLAEACTDLISHHKQLTVGLPPEPREK 851

  Fly  1019 TITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLFHEMLRLRVGLIIQVMAKE 1083
            .||.|||..||..||::|.|.|.|.|:||||:||||||::|::|.||.:|||||:|||:||||.|
Zfish   852 VITVPLPPEELISLIYEASGQDISIAVLTQEIMVYLAMYVRSQPSLFGDMLRLRIGLIMQVMATE 916

  Fly  1084 LSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEFAV--------SSVARGNLSI-------- 1132
            |:|:|:|.||.|||.|::||||:|||||:||||||||.|        ||.....:||
Zfish   917 LARSLHCSGEEASESLMSLSPFDMKNLLHHILSGKEFGVERSMRPIQSSATSPAISIHELGHTGA 981

  Fly  1133 -------------------------------------VSCKSSRVSKKS-QIGLGDPEGEDALIA 1159
                                                 .|.:|:|.|..| ..|:..|.|......
Zfish   982 TKTERTGIRKLKTEIKQLDDSRPISIYSSSHSISSNVTSPRSTRCSSPSTPSGILSPTGTGDCHL 1046

  Fly  1160 TIDDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLEKCQGLAIEGRVLQQSLTQEMTPGELKFALE 1224
            ..::||||||||||||||:||||..||.:||.:|:||.||:|.|.||..|.|:|||.||:|||:.
Zfish  1047 QWEERQGQWLRRRRLDGAINRVPMGFYQKVWKILQKCHGLSIAGYVLPSSTTREMTEGEIKFAVH 1111

  Fly  1225 VETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPSLGGVIYVEHLVHKANQLFLEDQRKVQGDAT 1289
            ||:.||.:||||||||:|||:||||||.:.. :||:||:|:::.:||.||.||.:|||....:..
Zfish  1112 VESVLNHVPQPEYRQLLVEAIMVLTLVADME-IPSVGGIIHIDRIVHMANDLFQQDQRSSGANEY 1175

  Fly  1290 LCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSRA-VALVLDCVP 1348
            ..         :|..|:|         ||...||||||||||||||:|:| |..|.|.:|
Zfish  1176 FL---------EQDPATG---------ICNFFYDSAPSGSYGTMTYLSKAVVTYVQDFLP 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:279112	283/430 (66%)
CG7766	NP_001245588.1	Glyco_hydro_15	<959..1075	CDD:279112	66/116 (57%)
phka2	XP_021335546.1	Glyco_hydro_15	8..>437	CDD:307049	281/428 (66%)
phka2	XP_021335546.1	Glyco_hydro_15	<790..908	CDD:330284	66/117 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596602
Domainoid	1	1.000	877	1.000	Domainoid score	I54
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H246
Inparanoid	1	1.050	1130	1.000	Inparanoid score	I211
OMA	1	1.010	-	-		QHG52853
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0004979
OrthoInspector	1	1.000	-	-		otm26510
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	1	1.100	-	-	LDO	PTHR10749
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4621
SonicParanoid	1	1.000	-	-		X2995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.930