DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7766 and PHKA2

DIOPT Version :9

Sequence 1:	NP_001245588.1	Gene:	CG7766 / 31839	FlyBaseID:	FBgn0030087	Length:	1358	Species:	Drosophila melanogaster
Sequence 2:	XP_006724559.1	Gene:	PHKA2 / 5256	HGNCID:	8926	Length:	1243	Species:	Homo sapiens

Alignment Length:	1458	Identity:	646/1458 - (44%)
Similarity:	830/1458 - (56%)	Gaps:	326/1458 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIA 65
            ||||||||||||.|.|:|.:.||.:|.|||||..||:....||:|||:|.|||||||.|||:|.|
Human     1 MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHEQKDAWVRDNIYSILAVWGLGMAYRKNA 65

  Fly    66 DQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEW 130
            |:|||:||.|||||:.||||||||..||.|..||||||.|||..|||||||::.....||.|::|
Human    66 DRDEDKAKAYELEQNVVKLMRGLLQCMMRQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVGDDQW 130

  Fly   131 GHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEP 195
            ||||:||.||:||.|||||||||:|:|:||||:||||||||||:||.:.|||:||||||||.|.|
Human   131 GHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIP 195

  Fly   196 ELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLL 260
            ||||||:|||||||||::|||||||.||..||||||.||...||::|.|||||.|.|||:|:|||
Human   196 ELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLL 260

  Fly   261 CVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIE 325
            .:|.||||||:|..|::.||:.|:|:|||:|||.|||||||:||:|||:||:|:..||::|||||
Human   261 SIISFPAFAVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKLFENIE 325

  Fly   326 CEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQ 390
            ||||:|:.|.|:...|..|...|:||...||.|::|.::||.||||.||||.:.|..||:.|.:.
Human   326 CEWPVFWTYFIIDGVFSGDAVQVQEYREALEGILIRGKNGIRLVPELYAVPPNKVDEEYKNPHTV 390

  Fly   391 VREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKL 455
            .|..:|:.|.||||||:||..||.|||||.||:||||||.....||||||||.::||:|.|:|.|
Human   391 DRVPMGKVPHLWGQSLYILSSLLAEGFLAAGEIDPLNRRFSTSVKPDVVVQVTVLAENNHIKDLL 455

  Fly   456 AEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAF 520
            .:|.::||:||::.||:|||.|:|||:|..||||:.:.||||..|.:|:|.|||||.::::||.|
Human   456 RKHGVNVQSIADIHPIQVQPGRILSHIYAKLGRNKNMNLSGRPYRHIGVLGTSKLYVIRNQIFTF 520

  Fly   521 TPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYMLDQD--KIPLAMIQ 583
            |||..|...:|...|.:::.......||:|...|| |.||||:|...:..||..|  .|..|::.
Human   521 TPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWR-MTGRPTLTFPISRTMLTNDGSDIHSAVLS 584

  Fly   584 TMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFLGSTED---------------------GY-P 626
            |:|||:.||..|.||.||:|.:||.||..|.|:||....|                     || .
Human   585 TIRKLEDGYFGGARVKLGNLSEFLTTSFYTYLTFLDPDCDEKLFDNASEGTFSPDSDSDLVGYLE 649

  Fly   627 DRLHPDVQTYLD---EHLLRSFSNRSTMNLRGGQLRPRTLRRRMSCK--------GAIKKTRSI- 679
            |..:.:.|..||   .|||:|.|.||       .|.|       .||        .||..||.|
Human   650 DTCNQESQDELDHYINHLLQSTSLRS-------YLPP-------LCKNTEDRHVFSAIHSTRDIL 700

  Fly   680 NVDSDNLGMEGP-SPLTERRLSSIVPPPWLQANKQSHVSVFATTP--EEGPTSSPLSLGNDLIRE 741
            :|.:...|:|.| .|:|       :|...|.|:::|...|.:..|  |:.|.|           :
Human   701 SVMAKAKGLEVPFVPMT-------LPTKVLSAHRKSLNLVDSPQPLLEKVPES-----------D 747

  Fly   742 NIYPVDPHHSRSAIDRRSEFVRQQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGD 806
            ..:|.|.|                                  .|.:.|:|:..|::..||::|.|
Human   748 FQWPRDDH----------------------------------GDVDCEKLVEQLKDCSNLQDQAD 778

  Fly   807 ILQYLVDTQGLDFNTAGLGFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDG 871
            ||..|...:|..::|
Human   779 ILYILYVIKGPSWDT-------------------------------------------------- 793

  Fly   872 AKKSPTIVLPTVIIDAATIPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNM 936
                                                                     |:|..:.
Human   794 ---------------------------------------------------------NLSGQHG- 800

  Fly   937 SPHENNHDSSQSEGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDL 1001
                                 |||::||..||.||...:.|||:|:.:|:|.|:||.||:|.|||
Human   801 ---------------------VTVQNLLGELYGKAGLNQEWGLIRYISGLLRKKVEVLAEACTDL 844

  Fly  1002 LVRQKQVTVGMPPN-NEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLF 1065
            |..|||:|||:||. .|..|:||||..||.:||::|.|.|.|.|:||||::|||||::|.:|.||
Human   845 LSHQKQLTVGLPPEPREKIISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLF 909

  Fly  1066 HEMLRLRVGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEF---------- 1120
            .||||||:||||||||.||:|:|||.||.|||.|:|||||:|||||:||||||||
Human   910 VEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSGKEFGVERSVRPIH 974

  Fly  1121 ---------------------------------------------------AVSSVARGNLSIVS 1134
                                                               |.||.|..:.|.|:
Human   975 SSTSSPTISIHEVGHTGVTKTERSGINRLRSEMKQMTRRFSADEQFFSVGQAASSSAHSSKSAVT 1039

  Fly  1135 -----CKSSRVSKKSQIGLGDPEGEDALIATIDDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLE 1194
                 |:||..|..:.....|..|..   ....:||||||||||||||:||||..||.|||.:|:
Human  1040 VPRDYCRSSTPSSPTGTSSSDSGGHH---IGWGERQGQWLRRRRLDGAINRVPVGFYQRVWKILQ 1101

  Fly  1195 KCQGLAIEGRVLQQSLTQEMTPGELKFALEVETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPS 1259
            ||.||:|:|.||..|.|:||||.|:|||:.||:.||::||||||||:|||:|||||:::..|. |
Human  1102 KCHGLSIDGYVLPSSTTREMTPHEIKFAVHVESVLNRVPQPEYRQLLVEAIMVLTLLSDTEMT-S 1165

  Fly  1260 LGGVIYVEHLVHKANQLFLEDQRKVQGDATLCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDS 1324
            :||:|:|:.:|..|:||||:||..:....||         |:.||..          ||...|||
Human  1166 IGGIIHVDQIVQMASQLFLQDQVSIGAMDTL---------EKDQATG----------ICHFFYDS 1211

  Fly  1325 APSGSYGTMTYMSRAVALVL-DCVPKHG 1351
            ||||:||||||::||||..| :.:|..|
Human  1212 APSGAYGTMTYLTRAVASYLQELLPNSG 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:279112	276/430 (64%)
CG7766	NP_001245588.1	Glyco_hydro_15	<959..1075	CDD:279112	66/116 (57%)
PHKA2	XP_006724559.1	Glyco_hydro_15	8..>439	CDD:279112	276/430 (64%)
PHKA2	XP_006724559.1	Glyco_hydro_15	<802..919	CDD:279112	66/116 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160266
Domainoid	1	1.000	860	1.000	Domainoid score	I57
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H246
Inparanoid	1	1.050	1108	1.000	Inparanoid score	I230
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52853
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0004979
OrthoInspector	1	1.000	-	-		otm42182
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	1	1.100	-	-	LDO	PTHR10749
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4621
SonicParanoid	1	1.000	-	-		X2995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840