Protein Alignment CG7766 and PHKA1

DIOPT Version :10

• Sequence 1: NP_001245588.1
• Gene: CG7766 / 31839
• FlyBaseID: FBgn0030087
• Length: 1358
• Species: Drosophila melanogaster
• Sequence 2: NP_001417997.1
• Gene: PHKA1 / 5255
• HGNCID: 8925
• Length: 1240
• Species: Homo sapiens
• Alignment Length: 1433
• Identity: 632/1433 - (44%)
• Similarity: 815/1433 - (56%)
• Gaps: 300/1433 - (20%)

  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIA 65
            ||||||||||||.|.|:|.:.||.||.|||||.|||.....||:|||||.|||||||.:||:|.|
Human     1 MRSRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSILAVWGLGLAYRKNA 65

  Fly    66 DQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEW 130
            |:|||:||.||||||.||||||||..|:.|.||||.||.:||..|||||||::|....||.|::|
Human    66 DRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQW 130

  Fly   131 GHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEP 195
            ||||:||.|:|||.|||||||||.|:.|||||:||||||||||:||...|:||||||||||.|..
Human   131 GHLQLDATSVYLLFLAQMTASGLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGIS 195

  Fly   196 ELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLL 260
            ||||||:|||||||||::||||||.:|||.|||||||||...||::|.|:|||.|.|||:|:.||
Human   196 ELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNSLLPRASTSKEVDASLL 260

  Fly   261 CVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIE 325
            .|:.||||||:|:||:..||..|:::|||:|||.|||||||:||||||:|||||..||::|||||
Human   261 SVVSFPAFAVEDSQLVELTKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFENIE 325

  Fly   326 CEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQ 390
            ||||||:.|.||...|..:...|:||...||.::::.::|:.|:||.|:||.|.|..|||.|.:.
Human   326 CEWPLFWTYFILDGVFSGNAEQVQEYKEALEAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTV 390

  Fly   391 VREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKL 455
            .|..:|:.|.:|||||:|||.|:.|||||.||:||||||.....||||||||.|:||..||:..|
Human   391 DRVPMGKLPHMWGQSLYILGSLMAEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTIL 455

  Fly   456 AEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAF 520
            .:..::|:|||||.||.|||||:|||:|:.||.|.::.||||..|.:|:|.|||||.::..||.|
Human   456 KDKGIYVETIAEVYPIRVQPARILSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFTF 520

  Fly   521 TPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYMLDQDKIPL--AMIQ 583
            |||.||.:::|...|..::.....|:|::|.:.|| |.|:||||...:|.|||:|...|  :::.
Human   521 TPQFIDQQQFYLALDNKMIVEMLRTDLSYLCSRWR-MTGQPTITFPISHSMLDEDGTSLNSSILA 584

  Fly   584 TMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFLGSTEDG------YPD--------------- 627
            .:||::.||..|.||..|.|.:||.||..|.|||:....:|      |.|
Human   585 ALRKMQDGYFGGARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNYDYLESGNWMNDYD 649

  Fly   628 -----RLHPDVQTYLDEHLLRSFSNRSTM---NLRGG----QLRPRTLRRRMSCKGAIKKTRSIN 680
                 |...:|..||| |||...:....:   :.:||    |...:|....||   .:.|.:.::
Human   650 STSHARCGDEVARYLD-HLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMS---LVTKAKELH 710

  Fly   681 VDSDNLGMEGPSPLTERRLSSIVPPPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENIYP 745
            |  .|:.|..|:.|             .||::.|.                          |:
Human   711 V--QNVHMYLPTKL-------------FQASRPSF--------------------------NL-- 732

  Fly   746 VDPHHSRSAIDRRSEFVRQQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGDILQY 810
            :|..|.|            ||..||.:.::.|.......:.:.:.|:..|:||.:|:||.|||..
Human   733 LDSPHPR------------QENQVPSVRVEIHLPRDQSGEVDFKALVLQLKETSSLQEQADILYM 785

  Fly   811 LVDTQGLDFNTAGLGFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDGAKKS 875
            |...:|.|:||.
Human   786 LYTMKGPDWNTE----------------------------------------------------- 797

  Fly   876 PTIVLPTVIIDAATIPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNMSPHE 940
                                                                             
Human   798 ----------------------------------------------------------------- 797

  Fly   941 NNHDSSQSEGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDLLVRQ 1005
                       |...|..|||:||..||.|..:.:.|||:|:.:|:|.|:||.|.:|.||||..|
Human   798 -----------LYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQ 851

  Fly  1006 KQVTVGMPPN-NEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLFHEML 1069
            |.:|||:||. .|.||:||||...|.|||.:|...|.|.::||||:||||||::||:|.||.||.
Human   852 KHLTVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAEMF 916

  Fly  1070 RLRVGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEFAVSSVAR---GNLS 1131
            |||:||||||||.||:.:|.|..|.|:|.|:||||..|||||:||||||||.|....|   .|:|
Human   917 RLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHHILSGKEFGVERSVRPTDSNVS 981

  Fly  1132 --------------------IVSCKSS---------RVSKKSQIGLGDPEGEDALIATI------ 1161
                                |:..||.         .:|.:||...|.|.|.|.:..:.
Human   982 PAISIHEIGAVGATKTERTGIMQLKSEIKQVEFRRLSISAESQSNGGHPLGIDLMSPSFMSPGTS 1046

  Fly  1162 ------------------DDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLEKCQGLAIEGRVLQQ 1208
                              |.|||||.|||||||||||||..||.:||.||:||.||::||.||..
Human  1047 MTPSSGSFPSAYDQQSSKDSRQGQWQRRRRLDGALNRVPVGFYQKVWKVLQKCHGLSVEGFVLPS 1111

  Fly  1209 SLTQEMTPGELKFALEVETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPSLGGVIYVEHLVHKA 1273
            |.|:||||||:||::.||:.||::||||||||:|||::|||::.:.. :.|:|.:|.||.:||.|
Human  1112 STTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADIE-IHSIGSIIAVEKIVHIA 1175

  Fly  1274 NQLFLEDQRKVQGDATLCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSR 1338
            |.|||::|:.:..|.|:..   ||      .|||         ||..||||||||.:|||||:|:
Human  1176 NDLFLQEQKTLGADDTMLA---KD------PASG---------ICTLLYDSAPSGRFGTMTYLSK 1222

  Fly  1339 AVA 1341
            |.|
Human  1223 AAA 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:395586	276/430 (64%)
		Bac_rhamnosid6H	<959..1075	CDD:481215	64/116 (55%)
		KPBB_C	1086..>1260	CDD:437124	98/229 (43%)
PHKA1	NP_001417997.1	Glyco_hydro_15	8..>439	CDD:395586	276/430 (64%)
		Bac_rhamnosid6H	<804..922	CDD:481215	64/117 (55%)
		Calmodulin-binding. /evidence=ECO:0000255	810..840		13/29 (45%)
		Calmodulin-binding. /evidence=ECO:0000255	1063..1103		28/39 (72%)
		KPBB_C	<1077..>1151	CDD:437124	48/73 (66%)