DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7766 and C14B9.8

DIOPT Version :9

Sequence 1:	NP_001245588.1	Gene:	CG7766 / 31839	FlyBaseID:	FBgn0030087	Length:	1358	Species:	Drosophila melanogaster
Sequence 2:	NP_001348739.1	Gene:	C14B9.8 / 176149	WormBaseID:	WBGene00015754	Length:	1232	Species:	Caenorhabditis elegans

Alignment Length:	1409	Identity:	551/1409 - (39%)
Similarity:	757/1409 - (53%)	Gaps:	251/1409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFP-ASNVNSHAWIRDNVYCILAVWGLSMAYKKI 64
            |||||.||||||....:|.:.|.:||.|:|.||. ..:...|||:|||||...|:|.|..||.|.
Worm     1 MRSRSGSGVRLDRILFMVEQTICSHQNPITALFANQKDFPGHAWVRDNVYIAQALWALYRAYMKC 65

  Fly    65 ADQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNE 129
            ||.|||..|..||..:|||:|:.:|..:|.|.:|||.||..|.|.|:||:|::......|..|.:
Worm    66 ADFDEDLTKAKELGFTCVKMMQSILECLMRQAEKVELFKKYQRPLDALHSKFAVGTKGTVCGDAD 130

  Fly   130 WGHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGE 194
            |||||:||:|||||.|||:||||||:|.:.|||:||||||:|||:.|..||||:||||||||.|.
Worm   131 WGHLQMDAISLYLLTLAQITASGLQVVRNFDEVAFIQNLVYYIETGYRTPDYGVWERGDKTNQGI 195

  Fly   195 PELNASSIGMAKAALEAMNEL-DLF--GARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELD 256
            .|||||||||.||||:|:|:: |||  |:||   ||:|||.||..:|.|||.|||||||.|||.|
Worm   196 RELNASSIGMVKAALQALNDVGDLFVDGSRG---SVVHVLPDEIEQCSAVLSSMLPRESFSKETD 257

  Fly   257 SGLLCVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMF 321
            :.||.:|.:|||.|:|.:|:..|::.|..||.|||||:||:||||:|..||.|||||.:.||:.|
Worm   258 AALLGIISYPAFCVEDPELVSQTRETITQRLLGKYGCRRFMRDGYKTVLEDASRLYYNKSELQQF 322

  Fly   322 ENIECEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQK 386
            |:||||||:|.|||||...:..|..|||.|..:||.::|.|:.|..||||.|.|.::.|..|...
Worm   323 EDIECEWPIFLCYLILDAMYSKDDDAVEAYWRQLESVLVLSDKGFRLVPELYVVLKEHVSAEKAH 387

  Fly   387 PGSQVREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGA-QKKPDVVVQVVIIAEDNE 450
            ||:|.|...|..||||.|||:::..||.||||...|||||:|||.. :|:|...|||.::||..:
Worm   388 PGTQDRVPGGATPFLWAQSLYVIICLLYEGFLLPAELDPLSRRLSVYEKRPPCEVQVTVLAESLD 452

  Fly   451 IRDKLAEHDLHVQTIAEVAPI-EVQPARVLSHLYTYLGRNRKLGLSGRK-SRDVGILSTSKLYSL 513
            ::.:|..||:|||.:.|:.|: .:.||..|..|...:|.::||.||||. .|.:|:||||:||.:
Worm   453 VQRELRAHDIHVQCVDEIDPVFTILPASALGQLLAKIGESKKLNLSGRPLDRPIGLLSTSRLYQI 517

  Fly   514 KDRIFAFTPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWR--HMLGRPTITLMATHYMLDQD- 575
            .::...||||.:|....:...|..:|...:::.|.::..:|.  .:.|||.:.|:.|..||..:
Worm   518 GNKFVIFTPQFMDSRRSHLMYDIRILTDEWSSELQYIYASWNSVSISGRPLVVLVITQGMLSTEG 582

  Fly   576 -----------KIPLAMIQTMRKLKSGYINGT---RVMLGSLKDFLNTSAITDLSFLG-STEDGY 625
                       .:...:|..::|:.:||::|.   ||::..|.||..|:|::.:.|.. |.||..
Worm   583 LSHFSNIHLNRHMKSTVIGAIKKINTGYLSGASVCRVVMKDLSDFFRTTAVSKMEFRDKSAEDTL 647

  Fly   626 PDRLHPDVQ-TYLDEHL--LRSFSNRSTMNLRGGQLRPRTLRRRMSCKG-----AIKKT----RS 678
            .......|| |.|.|..  .:..|:......||    ||||||..|.|.     |:.|.    ||
Worm   648 RSVAAEKVQFTLLTEDATEAKRSSDEKITTPRG----PRTLRRGESVKDRSAYTAVHKASMRHRS 708

  Fly   679 INVDSDNLGMEGPSPLTERRLSSIVPPPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENI 743
            |.:||::      :.|.:.||:....|    .:.|...|.:.:.|   ||.:||.|
Worm   709 IALDSND------ADLMKLRLAYKSRP----RDLQDMDSTYQSPP---PTQTPLGL--------- 751

  Fly   744 YPVDPHHS---RSAIDRRSEFVRQQEITVPKILIQRHRAET--NFADTEVEELIAMLRETENLEE 803
              |..|.|   |..:.:.:....:.|.|        ||..|  ...:.:.::|:.::.||..|||
Worm   752 --VKEHSSGELRQQLLKTTRRGAENETT--------HRDLTAEQMNEMKADDLLDLVNETTVLEE 806

  Fly   804 QGDILQYLVDTQGLDFNTAGLGFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGG 868
            |..|:..|....|.|::|. ||.::
Worm   807 QISIVHCLWMKFGPDYDTE-LGCQH---------------------------------------- 830

  Fly   869 GDGAKKSPTIVLPTVIIDAATIPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNH 933

Worm   831 ----------------------------------------------------------------- 830

  Fly   934 NNMSPHENNHDSSQSEGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAV 998
                                    :|||.|::.::.|||:.:.|.|||.|||:|.|::|:|:|||
Worm   831 ------------------------ITVRMLMEEVHTKACEAREWALVRLTAGLLKKQLEELSKAV 871

  Fly   999 TDLLVRQKQVTVGMPPNNEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQ 1063
            |.|||||||:|||:....|..||.|....||.::::.|||||.::..|.||::|||...:||||:
Worm   872 THLLVRQKQITVGIASKKEEVITCPKTNEELEKIMNRAYGDDANSFTLAQEIIVYLGSLVRTEPK 936

  Fly  1064 LFHEMLRLRVGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGK---EFA---- 1121
            ||.||.|||:||||||:|.||||..|..|..|:|.||.:||||:|::::.:|||:   |:|
Worm   937 LFLEMFRLRIGLIIQVLASELSRLRNISGAEAAETLLTVSPFELKSMIFSLLSGRLLEEYAEDGI 1001

  Fly  1122 ------------VSSVARGNLSIVSCKSSRVSKKSQIGLGDPEGEDA-LIATIDDRQ-GQWLRRR 1172
                        :.|..|   .|...||.|.|.:|..||..|:.||. ..|..||.| |.|||.|
Worm  1002 HYSDTIRETRTGIGSFRR---QIEERKSLRKSTRSVGGLEIPKEEDEDEEADEDDFQFGIWLRHR 1063

  Fly  1173 RLDGALNRVPRDFYSRVWTVLEKC-QGLAIEGRVLQQSLTQEMTPGELKFALEVETALNQIPQPE 1236
            |:||||||||..||:.:|..:.|. .|:.|...||...||||||..|:|||||.|.|||:|.:||
Worm  1064 RIDGALNRVPNGFYAILWDTVHKMPHGVKINDTVLHWGLTQEMTRKEIKFALESEEALNRIAEPE 1128

  Fly  1237 YRQLVVEALMVL-----TLVTEHNMVPSLGGVIYVEHLVHKANQLFLEDQRKVQGDATLCCAKIK 1296
            ||:||||.|.:|     .::.|...:|. ...:.|:|::|.|||:|::..:.::.....|||...
Worm  1129 YRELVVETLWLLGRLEKLVLLEQPNIPR-DRPLDVDHILHVANQIFVDHNKHLETIVMECCASSN 1192

  Fly  1297 DGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSRAV 1340
            ....:         |.||..||:|.|||||:|.|||..|:.||:
Worm  1193 PNNTR---------CDGARNICKHFYDSAPAGEYGTSHYIIRAL 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:279112	240/435 (55%)
CG7766	NP_001245588.1	Glyco_hydro_15	<959..1075	CDD:279112	60/115 (52%)
C14B9.8	NP_001348739.1	Glyco_hydro_15	8..>434	CDD:330284	238/428 (56%)
C14B9.8	NP_001348739.1	Glyco_hydro_15	<832..948	CDD:330284	60/115 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167720
Domainoid	1	1.000	699	1.000	Domainoid score	I53
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H246
Inparanoid	1	1.050	887	1.000	Inparanoid score	I198
Isobase	1	0.950	-	0	Normalized mean entropy	S4034
OMA	1	1.010	-	-		QHG52853
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0004979
OrthoInspector	1	1.000	-	-		oto17887
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	1	1.100	-	-	LDO	PTHR10749
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4621
SonicParanoid	1	1.000	-	-		X2995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.880