DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7766 and phka1

DIOPT Version :9

Sequence 1:	NP_001245588.1	Gene:	CG7766 / 31839	FlyBaseID:	FBgn0030087	Length:	1358	Species:	Drosophila melanogaster
Sequence 2:	XP_031746091.1	Gene:	phka1 / 100158624	XenbaseID:	XB-GENE-5969937	Length:	1233	Species:	Xenopus tropicalis

Alignment Length:	1435	Identity:	631/1435 - (43%)
Similarity:	822/1435 - (57%)	Gaps:	290/1435 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIA 65
            ||||||||||||.|.::|.:.||.||.|||||.|||:....||:|||||.|||||||.:||:|.|
Frog     1 MRSRSNSGVRLDRYAKLVQQTILCHQNPVTGLLPASSDQKDAWVRDNVYTILAVWGLGLAYRKNA 65

  Fly    66 DQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEW 130
            |:|||:||.|||||:.||||||||..||.|..|||:||.:|:..|:|||||::.....||.|::|
Frog    66 DRDEDKAKAYELEQNVVKLMRGLLQCMMRQVSKVEEFKYSQNTKDALHAKYNTNTCSTVVGDDQW 130

  Fly   131 GHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEP 195
            ||||:||.|:|||.|||||||||.|:::||||:||||||||:|:||...|:|:||||||||.|..
Frog   131 GHLQLDATSIYLLFLAQMTASGLHIIYNLDEVNFIQNLVFYVEAAYKTADFGMWERGDKTNQGIT 195

  Fly   196 ELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLL 260
            ||||||:||||||||:::||:||||:|||.||||||:||...||::|.|||||.|.|||:|:|:|
Frog   196 ELNASSVGMAKAALESLDELNLFGAKGGPQSVIHVLSDEIQHCQSILHSMLPRASTSKEIDAGVL 260

  Fly   261 CVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIE 325
            .||.||||||:|:.|:..||..|:.:|||:|||.||||||||||||||.|||||..||::|||||
Frog   261 SVISFPAFAVEDSHLVRITKQEIIDKLQGRYGCCRFLRDGYRTPKEDPGRLYYEPAELKLFENIE 325

  Fly   326 CEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQ 390
            ||||||:.|.||...|.|:...|:||...:::::::.:.|:.||||.|:||:|.|..||:.|.:.
Frog   326 CEWPLFWTYFILDGIFSSNHEQVQEYKQAIDEVLIKGKSGVRLVPELYSVPEDKVEVEYEHPHTV 390

  Fly   391 VREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKL 455
            .|..:|:.|.:|||||:|||.|:.|||||.||:||||||.....||||||||.|:||.:||::.|
Frog   391 DRIPLGKLPHMWGQSLYILGCLMSEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETDEIQEIL 455

  Fly   456 AEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAF 520
            .:|.:..:|:|.|.||.|||||:|||:|..||||||:.||||..|::|:|.|||||:::..||||
Frog   456 KKHGIEAETVAGVYPIRVQPARILSHIYARLGRNRKMNLSGRPYRNMGVLGTSKLYTIRQNIFAF 520

  Fly   521 TPQHIDYEEYYTTRDPDLLASNFTTNLAFLTNNWRHMLGRPTITLMATHYMLDQ-----DKIPLA 580
            |||.||.:::|...|..::.....|:|::|.:.|| |.||||||...:|.|||.     |.:.||
Frog   521 TPQFIDQQQFYLALDNRMIVEMLRTDLSYLCSRWR-MTGRPTITFPISHTMLDDSGNDLDPVVLA 584

  Fly   581 MIQTMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFL-----------GSTEDG-------YPD 627
               |:|||:.||..|.|...|.|..|||||....|||:           ||...|       .||
Frog   585 ---TIRKLQDGYFGGARTQTGFLSKFLNTSCCKHLSFMDAGVEGKLSTWGSVNRGGQPIIVREPD 646

  Fly   628 R--------LHPDVQTYLDEHLLRSFSNRSTMNLRGGQLRPRTLRRRMSCKGAIKKTRSINVDSD 684
            .        :..:|..||::.|..|....|..:.|||:.|         .|.||..||      |
Frog   647 EAPSADDEDVDDEVSLYLNQLLGMSSPKPSPTSQRGGRHR---------FKAAIHSTR------D 696

  Fly   685 NLGMEGPSP-LTERRLSSIVPPPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENIYPVDP 748
            .|.:...:. |..:.:...:|.....|::.|.                     ||:..     .|
Frog   697 MLSLRSKAKGLNVQDIQMYLPSKLFLASQPSF---------------------DLLES-----AP 735

  Fly   749 HHSRSAIDRRSEFVRQQEITVPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGDILQYLVD 813
            .:..|.             .:|.|..:.|..:......:...::..||||.||:||.|||..|..
Frog   736 SYQASG-------------RIPTIHAELHLPKDTEGQVDYAAMVDHLRETNNLQEQADILYLLYT 787

  Fly   814 TQGLDFNTAGLGFKNKSEENATPNANNAELEQAFVDDAVLELADGGGGAGAGAGGGDGAKKSPTI 878
            .:|.|::|...|
Frog   788 MKGGDWDTKIYG----------------------------------------------------- 799

  Fly   879 VLPTVIIDAATIPAGTGTDPDNAAHPSSATANSNNSHCIGNTSNISSSSSNISNHNNMSPHENNH 943

Frog   800 ----------------------------------------------------------------- 799

  Fly   944 DSSQSEGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDLLVRQKQV 1008
                     :.|  |||:||||.||.|....:.|.|:|..:|:|.|:||.|.:|.||||..|||:
Frog   800 ---------QPG--VTVKDLLKDLYGKVGSMRQWALIRGISGILKKKVEALDEACTDLLSHQKQL 853

  Fly  1009 TVGMPPN-NEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLFHEMLRLR 1072
            |||:||. .|..||||||..:|.:||.:|...:.:.::||||:||||||::||:|.||.||.|||
Frog   854 TVGLPPEPREIAITAPLPYEKLIRLIDEASEQNRTISILTQEIMVYLAMYMRTQPSLFAEMFRLR 918

  Fly  1073 VGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEFAVSSVARGNLSIVS--- 1134
            :||||||||.|||.:|.|..|.|:|.|:||||.:|||||:||||||||.|....||....||
Frog   919 IGLIIQVMATELSHSLRCSAEEATESLMNLSPSDMKNLLHHILSGKEFGVERSVRGGEPWVSPAI 983

  Fly  1135 ----------CKSSRVS---KKSQIGLGD-------PEGEDALI--------------------A 1159
                      .||.|..   .||:|.|.|       .||:|..:                    :
Frog   984 SIHELGAVGATKSERAGITRLKSEIKLLDKRRLSLAAEGQDMDLSSGMSLKPGDSLSVSGDLSTS 1048

  Fly  1160 TI-------DDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLEKCQGLAIEGRVLQQSLTQEMTPG 1217
            ||       |.|||||||||||||||||||..||.:||.:|:||.||::||.||..|.|:|||||
Frog  1049 TISDSDSANDSRQGQWLRRRRLDGALNRVPIGFYQKVWLILQKCHGLSVEGFVLPSSSTREMTPG 1113

  Fly  1218 ELKFALEVETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPSLGGVIYVEHLVHKANQLFLEDQR 1282
            ||||:..||:.||::||||||||:|||::|||::.:.: :.|:||:|:||.:||.||:||.::|:
Frog  1114 ELKFSAHVESVLNRVPQPEYRQLLVEAILVLTMLADVD-IQSVGGIIHVEKIVHIANELFCQEQK 1177

  Fly  1283 KVQGDATLCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSRAVALVL-DC 1346
            .:..|.|                  ||.......||..||||||||.:|||||:|::||:.| :.
Frog  1178 VLGADDT------------------MLDVDPTTGICHLLYDSAPSGRFGTMTYLSKSVAITLQES 1224

  Fly  1347 VPKHG 1351
            :|..|
Frog  1225 LPHSG 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7766	NP_001245588.1	Glyco_hydro_15	8..>439	CDD:279112	267/430 (62%)
CG7766	NP_001245588.1	Glyco_hydro_15	<959..1075	CDD:279112	62/116 (53%)
phka1	XP_031746091.1	Glyco_hydro_15	8..571	CDD:395586	335/563 (60%)
phka1	XP_031746091.1	Glyco_hydro_15	<804..921	CDD:395586	62/116 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	859	1.000	Domainoid score	I61
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1107	1.000	Inparanoid score	I234
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0004979
OrthoInspector	1	1.000	-	-		otm49409
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060