DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT2 and CCT7

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_012424.1	Gene:	CCT7 / 853333	SGDID:	S000003647	Length:	550	Species:	Saccharomyces cerevisiae

Alignment Length:	519	Identity:	169/519 - (32%)
Similarity:	286/519 - (55%)	Gaps:	13/519 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLK--NEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILR 72
            |||  .:|.:.|.::  :|:....:|:.:.:|.||||.|.|.::|.:.:.   ..::|||||||:
Yeast    12 VLKEGTDASQGKGQI--ISNINACVAVQEALKPTLGPLGSDILIVTSNQK---TTISNDGATILK 71

  Fly    73 AVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVA 137
            .:.|.:||||.|||:||.||.||||||||||:||.||::||:..:|:.:...:|:.|:|:|..:|
Yeast    72 LLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLA 136

  Fly   138 LEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRL-KGSGELKSIQI 201
            :|.:...|.|.:|.....|..|...|||.:|||::|.:.|||..:.||||:.| :...:.|.|.|
Yeast   137 VEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGI 201

  Fly   202 IKKSGGTLGDSFLDEGFLLDKKPGV----HQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLA 262
            .|..||.:.:|....|....|....    .||::..|.:||..|..::. |.:...:.::|:.:.
Yeast   202 KKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELEL-KAEKDNAEVRVEHVE 265

  Fly   263 KIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCT 327
            ....:..||.:.:.||:.::.:...|:.:::..|.:...|.|||..:........|.:.|:....
Yeast   266 DYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAV 330

  Fly   328 GGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQQILDEADRSLHD 392
            ||.|.||..:.....||.|.:.|::.||.:....|.|....:.||:::||..:|::.|.:|||||
Yeast   331 GGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHD 395

  Fly   393 ALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYD 457
            |:.::...::...|:.|||.:|..::..:...:....||:.:.|.|||:||..:|..:.:|||:|
Yeast   396 AIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFD 460

  Fly   458 SAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNII 521
            :.:::::||..|::|::..|:..|...:.|.....:.|...||...|.||:||..:||.||..|
Yeast   461 AIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	169/519 (33%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	169/519 (33%)
CCT7	NP_012424.1	TCP1_eta	9..529	CDD:239456	169/519 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820