DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and CCT6

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_010474.3	Gene:	CCT6 / 851768	SGDID:	S000002596	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	154/547 - (28%)
Similarity:	280/547 - (51%)	Gaps:	39/547 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSLNPVRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDG 67
            |||   ::|..:|:..:.:.|...:...|..:..::::.|||||..|:||   ..||::::|.||
Yeast     1 MSL---QLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLV---DGAGNIKLTKDG 59

  Fly    68 ATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQ 132
            ..:|..:.:.:|.|.::...:..|||..|||||:|..|..||||:|.:.:::.:||:||..|:..
Yeast    60 KVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEI 124

  Fly   133 ATQVALEALT--AAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSG- 194
            |.:.:::.|.  ..::.|.|:|.:|   ||.:||::|.:|:.....:....:..|||:.:..:.
Yeast   125 ARKESMKFLDEFKISKTNLSNDREF---LLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQA 186

  Fly   195 ---ELKSIQIIKKSGGTLGDSFLDEGFLLDKKPGVH--QPQRIENARILIANTPMDTDKIKV--- 251
               :|..::|::....:..|:...:|.:|| ..|.|  .|.|::||.:||.|..::.:|.:|
Yeast   187 DNLDLHMVEIMQMQHLSPKDTTFIKGLVLD-HGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSG 250

  Fly   252 --FGSSIKVDSLA----KIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVM 310
              :.|:.:.|.||    |..|.::.:...:|.:|..:...|..|.||::.|......:||...::
Yeast   251 FFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315

  Fly   311 SIEHADFDGIERLAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEACTIVI 375
            ::..|....:|||...||||..::.|:.|...||...::.|..|||:.....:.....::|||:|
Yeast   316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILI 380

  Fly   376 RGATQQILDEADRSLHDALCVLAATVKESRIIFGGGC-----SEALMATAVLKKAAETPGKEAIA 435
            :|:|...|.:...::.|.|..:|..:|:..||.|.|.     |..|.:..:.|..|:  ||....
Yeast   381 KGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAK--GKTKTG 443

  Fly   436 IEAFARALLSLPTAIADNAGYDSAQLVSELR-----AGHAQGKQTLGLDMELGKVADVRELGITE 495
            |||||.|||.:|..:..|:|:|...:::.:.     |..:...:.:|:|:.:|...|....||.:
Yeast   444 IEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWD 508

  Fly   496 SFAVKRQVLMSASEAAEMILRVDNIIR 522
            |:.|.|..:..|:..|..:|..|.::|
Yeast   509 SYRVLRNAITGATGIASNLLLCDELLR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	154/547 (28%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	151/540 (28%)
CCT6	NP_010474.3	chap_CCT_zeta	2..542	CDD:274088	153/546 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810