DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and CCT4

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_010138.1	Gene:	CCT4 / 851412	SGDID:	S000002302	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	525	Identity:	173/525 - (32%)
Similarity:	285/525 - (54%)	Gaps:	35/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGVDNPAA 81
            :||.:..|.::.|.|.::.|.::::|||||||| ::.|.|  |.:.::|||.|||:.:.:.:|.|
Yeast    14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDK-MIKTSR--GEIIISNDGHTILKQMAILHPVA 75

  Fly    82 KILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQ 146
            ::||::|..||.|.|||||||.:|...||..||:|:.:.:||.||...::.|.:.:::.|.....
Yeast    76 RMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCH 140

  Fly   147 DNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSG----ELKSIQIIKKSGG 207
            ..|.||   |..|:..|.|:|||||:.|:..|.|.||||:|:::....    :|..|:::||.||
Yeast   141 KVSLSD---REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGG 202

  Fly   208 TLGDSFLDEGFLLD----KKPGVHQPQRIENARI-----LIANTPMDTDKIKVFGSSIKVDSLAK 263
            |:.|:.:.:|.:|.    |..|  .|.|.|.|:|     .|:....||:...:.....::|.:.|
Yeast   203 TIDDTEMIDGVVLTQTAIKSAG--GPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILK 265

  Fly   264 IADLEMAEKEKMKEKVDKILKHKCNVF-----INRQLIYNYPEQLFADARVMSIEHADFDGIERL 323
                  .|:..:.....||.|.||||.     |.|..:.:......:...:|.::..:.:.||.|
Yeast   266 ------EERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFL 324

  Fly   324 AYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEA---CTIVIRGATQQILDE 385
            :...|.:.::..|..:..:||..|::|::......::|.:|::...|   .::|||||...|:||
Yeast   325 SKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDE 389

  Fly   386 ADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAI 450
            .:|||||||||:...|||..:|.|||..|..::..:.|:|....|.:|...:.||.||..:||.:
Yeast   390 TERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTL 454

  Fly   451 ADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMIL 515
            |:|||.:|.::|:|||:.|..|:...|:.:......:..|..|.:...|....:..|||..:.||
Yeast   455 AENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSIL 519

  Fly   516 RVDNI 520
            |:|:|
Yeast   520 RIDDI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	173/525 (33%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	173/525 (33%)
CCT4	NP_010138.1	chap_CCT_delta	11..528	CDD:274083	173/525 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820