DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and HSP60

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_013360.1	Gene:	HSP60 / 850963	SGDID:	S000004249	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	586	Identity:	139/586 - (23%)
Similarity:	233/586 - (39%)	Gaps:	116/586 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VRVLKNEAQEEKAEM-----ARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDG 67
            :|.|...|.....|:     .|.|...|...:.:.|.:||||||.:   |...:..|..::|.||
Yeast    13 LRPLLRRAYSSHKELKFGVEGRASLLKGVETLAEAVAATLGPKGRN---VLIEQPFGPPKITKDG 74

  Fly    68 ATILRAVGV----DNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVS 128
            .|:.:::.:    :|..||:|.:::...:|..||||||.|||...:..|:.|.|....:|..:..
Yeast    75 VTVAKSIVLKDKFENMGAKLLQEVASKTNEAAGDGTTSATVLGRAIFTESVKNVAAGCNPMDLRR 139

  Fly   129 GWRQATQVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGS 193
            |.:.|.:..:|.|:|..::.::|:|        ||:....|.....|   ...|...|:.::...
Yeast   140 GSQVAVEKVIEFLSANKKEITTSEE--------IAQVATISANGDSH---VGKLLASAMEKVGKE 193

  Fly   194 GELKSIQIIKKSGGTLGDSF-LDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIK 257
            |     .|..:.|.||.|.. :.||...|:  |...|..|.:.:    ::.::.:|..:..|..|
Yeast   194 G-----VITIREGRTLEDELEVTEGMRFDR--GFISPYFITDPK----SSKVEFEKPLLLLSEKK 247

  Fly   258 VDSLAKIAD-LEMAEKEK-----MKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHAD 316
            :.|:..|.. ||::.:.:     :.|.||......|        |.|   :|....:|.:::...
Yeast   248 ISSIQDILPALEISNQSRRPLLIIAEDVDGEALAAC--------ILN---KLRGQVKVCAVKAPG 301

  Fly   317 F-----DGIERLAYCTGGEIVS----------TFENPSLVKLGECDVIEQVMIGEDT-LLRFSGV 365
            |     :.|..:|..|||.:.:          |.||     ||.||.|  .:..||| :|..||.
Yeast   302 FGDNRKNTIGDIAVLTGGTVFTEELDLKPEQCTIEN-----LGSCDSI--TVTKEDTVILNGSGP 359

  Fly   366 K----------------------------------LGEACTIVIRGATQQILDEADRSLHDALCV 396
            |                                  .|....|.:.||::..:.|......|||..
Yeast   360 KEAIQERIEQIKGSIDITTTNSYEKEKLQERLAKLSGGVAVIRVGGASEVEVGEKKDRYDDALNA 424

  Fly   397 LAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYDSAQL 461
            ..|.|:|.  |..||.:..:.|:.||.:.......:.:.::...:|:......|.:|||.:.:.:
Yeast   425 TRAAVEEG--ILPGGGTALVKASRVLDEVVVDNFDQKLGVDIIRKAITRPAKQIIENAGEEGSVI 487

  Fly   462 VSEL--RAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNIIRCA 524
            :.:|  ..|....|   |.|....:..|:...||.:.|.|.|..|:.||..|.::...:..|..|
Yeast   488 IGKLIDEYGDDFAK---GYDASKSEYTDMLATGIIDPFKVVRSGLVDASGVASLLATTEVAIVDA 549

  Fly   525 P 525
            |
Yeast   550 P 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	139/586 (24%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	138/584 (24%)
HSP60	NP_013360.1	GroEL	25..548	CDD:239460	134/570 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810