DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT2 and fab1

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	84/440 - (19%)
Similarity:	153/440 - (34%)	Gaps:	94/440 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 TTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQDNSSSDEKFRNDLLNIA 163
            ||:.:.|.:......|:|:.|.|....:...|.:..|:...  |||   |....|...|||::|
  Fly   449 TTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCS--TAA---NHFKPEHCSNDLMDI- 507

  Fly   164 RTTLSSKILHQHKDFFANLAVDAVMRLKGSGELKSIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQ 228
            |..::.|                                |..||...||.:..|....|.. .|:
  Fly   508 RNYVNFK--------------------------------KVPGGRRKDSKIVHGVAFSKNV-AHK 539

  Fly   229 PQ--RIENARILIANTPMDTDKIKVFGSSIKVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFI 291
            ..  .:...|||:...|:..::|:  |..:.::::.      :.|||.::....:|:..|.||.:
  Fly   540 DMATHVPFPRILLLQCPIVYERIE--GKFVTIETVL------LQEKEYLRNVCARIMSFKPNVVL 596

  Fly   292 NRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCTGGEIVSTFE-NPSLVKLGECDVIEQVMIG 355
            ..:.:....:.|.....|..:.......:|||:.....:|||:.| |.::.|||.|:........
  Fly   597 VHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNYN 661

  Fly   356 EDTLLRFSGVKLGEACTIVIRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATA 420
            ..||:.|..:......|.::||.:...|....|                            :|:|
  Fly   662 GKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKR----------------------------VASA 698

  Fly   421 VLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDM----E 481
            :|........:.:..:..||:.|...|:...........:..:|||:     |:.:.|:.    :
  Fly   699 LLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRS-----KRPIILERKSEDK 758

  Fly   482 LGKVADVRELGITESFAVKRQVLMSASEAAEMIL-------RVDNIIRCA 524
            :..:........|:.....:...:|.|..|..::       |.||..|.|
  Fly   759 ITTIVSENVSDFTDPLRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTA 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	84/440 (19%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	84/440 (19%)
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450	63/327 (19%)
		PIPKc	1413..1797	CDD:295374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930