DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and Cct6b

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_017452911.1	Gene:	Cct6b / 363658	RGDID:	1359453	Length:	543	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	147/549 - (26%)
Similarity:	284/549 - (51%)	Gaps:	51/549 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILR 72
            :::....|:..:::.|...:...|..:.|:::.:|||||..|:||:   .||.:::|.||..:|.
  Rat     4 IKIANPGAEVTRSQAALAVNICAARGLQDVLRPSLGPKGALKMLVS---GAGDIKLTKDGNVLLH 65

  Fly    73 AVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVA 137
            .:.:.:|.|.|:..::..||...||||||..::..|||::|:..:.:.|||:||..|:..|...|
  Rat    66 EMQIQHPTASIIAKVAAAQDHITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFDVAKTKA 130

  Fly   138 LEALTAAAQDNSSSDEKFRND-LLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSG---ELKS 198
            ||.|     |.....::.:.: ||::|||:|.:|:..:..|......||:|:.::..|   :|..
  Rat   131 LEVL-----DKIKVQKEMKREMLLDVARTSLRTKVHTELADILTEAVVDSVLAIRRPGIPIDLFM 190

  Fly   199 IQIIK-----KSGGTLGDSF-------LDEGFLLDKKPGVHQP---QRIENARILIANTPMDTDK 248
            ::|::     ::....||..       |..|.:||.  |...|   :::::|.|||.|..::.:|
  Rat   191 VEIVEMRHKSETDTQAGDRTQGLALPRLVRGLVLDH--GARHPRMKKQVQDAYILICNVSLEYEK 253

  Fly   249 IKVFGSSIKVDSLAKIADLEMAEKEKMKEKVDKIL---------KHKCNVFINRQLIYNYPEQLF 304
            .:| .|.....::.:...|..||::.::::|.||:         .:|..|.||::.|.....::.
  Rat   254 TEV-SSGFFYKTVEEKEKLVKAERKFIEDRVQKIIDLKQKVCAESNKGFVVINQKGIDPVSLEML 317

  Fly   305 ADARVMSIEHADFDGIERLAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGE 369
            |...::::..|....:|||....||..|::.|:.|...||...::.:..:||:   :|:.:   |
  Rat   318 AKHNIVALRRAKRRNLERLTLACGGLAVNSLEDLSEECLGHAGLVFEYTLGEE---KFTFI---E 376

  Fly   370 AC------TIVIRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAET 428
            .|      |::::|..:..|.:...:|.|.|..:...:::..::.|.|..|..:|.|::......
  Rat   377 DCVNPLSVTLLVKGPNKHTLIQIKDALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHCV 441

  Fly   429 PGKEAIAIEAFARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGI 493
            .|:..:.|:|||.|||.:|..:|.|:|||..:.:.:::..||:.|:.:|:|:..|:.....|.||
  Rat   442 QGRARLGIQAFADALLIIPKVLAQNSGYDLQETLIKIQTKHAESKELVGIDLNTGEPMVAAEAGI 506

  Fly   494 TESFAVKRQVLMSASEAAEMILRVDNIIR 522
            .:::.||:.:|.|.:..|..:|.||.|:|
  Rat   507 WDNYCVKKHILHSCTVIATNVLLVDEIMR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	147/549 (27%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	147/547 (27%)
Cct6b	XP_017452911.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810