DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and CCT5

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	180/524 - (34%)
Similarity:	292/524 - (55%)	Gaps:	15/524 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PVRVLKNEAQEEK--AEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGAT 69
            |..:|:::.::::  ...|..:..:.|..|...:|::|||||:|||:|:..   |.|.|||||||
  Fly    16 PFIILRDQERQKRITGTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPD---GDVTVTNDGAT 77

  Fly    70 ILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQAT 134
            |::.:.||:..||::|.:|:.||:|:|||||.|.|||..||.:||.|:::.:||..|..|:..|.
  Fly    78 IMKLMEVDHEIAKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAA 142

  Fly   135 QVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRL----KGSGE 195
            |.|::.|.|.||. ...|.|.:..|:.||.|||.|||:::.....|.:|||||:.:    |....
  Fly   143 QCAIKQLDAIAQP-FPVDPKNKEPLIQIAMTTLGSKIVNKCHRQMAEMAVDAVLNVADIEKKDVN 206

  Fly   196 LKSIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQ-PQRIENARILIANTPMDTDKIKVFGSSIKVD 259
            .:.|:|..|.||.:.||.|.:|.::||.....| |:.:.|.::.|...|.:..|.|. ...:.|.
  Fly   207 FELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKT-KHKLDVT 270

  Fly   260 SLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIERLA 324
            |......|...|:||..:.|.::......:.|.:....:....|.....:.::.......||.:|
  Fly   271 SAEDYRALREYEQEKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPAVRWVGGPEIELIA 335

  Fly   325 YCTGGEIVSTFENPSLVKLGECDVIEQVMIG--EDTLLRFSGVKLGEACTIVIRGATQQILDEAD 387
            ..|||.||..||..:..|||...::.::..|  :|.:|.....|..:|.||.:||....|:.||.
  Fly   336 IATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAEAK 400

  Fly   388 RSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIAD 452
            ||:|||:||:.:.||:|||::|||.:|...:.||.|:|.:....|..|..||:.||.|:|.|:|:
  Fly   401 RSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLALAE 465

  Fly   453 NAGYDSAQLVSELRAGH-AQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILR 516
            |:|....:.:|||:|.. |:.|.:||:|..|...:|::...:.||...|:|.::.:::..:|||:
  Fly   466 NSGLHPIETLSELKARQVAEKKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMILK 530

  Fly   517 VDNI 520
            :|::
  Fly   531 IDDV 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	180/524 (34%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	179/521 (34%)
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	180/524 (34%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	176/493 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840