DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and CCT4

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	172/525 - (32%)
Similarity:	281/525 - (53%)	Gaps:	35/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGVDNPAA 81
            :.|....|||:...|.|:.|.::::|||:||||::.|   ..|.|.:||||||||:.:.|.:|||
  Fly    20 KSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQA---GNGEVSITNDGATILKQMNVLHPAA 81

  Fly    82 KILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQ 146
            |:||::||.||...|||||||.|:|..||...|||:::.|||..|...:::.:..|:|.|...:.
  Fly    82 KMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMST 146

  Fly   147 DNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSG-----ELKSIQIIKKSG 206
            .....|   |..|:..|.|:|:||::.|.....|.:|||||:::...|     :||:|::|...|
  Fly   147 PIELDD---RETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLG 208

  Fly   207 GTLGDSFLDEGFLLD-KKPGVHQPQRIENARI-----LIANTPMDTDKIKVFGSSIKVDSLAKIA 265
            ||:.|:.|.:|.:.. :..|.:.|:|||.|:|     .|:....|.|...:......:|.:.|
  Fly   209 GTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYAAMDRVLK-- 271

  Fly   266 DLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYP----EQLFAD----ARVMSIEHADFDGIER 322
                .|:..:...|.:|.|..|||.:.::.|....    .|.|.|    ..|..:|..|.:.:.:
  Fly   272 ----EERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCK 332

  Fly   323 LAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVK-LGEACTIVIRGATQQILDEA 386
            ..:|   ..:::.::.:...|...|::|:|..|.:..::.:|:: :|...:|:.||:.:.:|:||
  Fly   333 TLHC---RPIASLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSIICRGSNKLVLEEA 394

  Fly   387 DRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIA 451
            .|||||||||:...||....|.|||..|..||..:...|....|.:|....|||.||..:|:.:|
  Fly   395 ARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLA 459

  Fly   452 DNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILR 516
            :|||.:....|:|||..||||::..|:::..|.:.|:....:.:...|....:..|:|....||:
  Fly   460 ENAGLNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILK 524

  Fly   517 VDNII 521
            :|:|:
  Fly   525 IDDIV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	172/525 (33%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	172/525 (33%)
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	172/525 (33%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	165/506 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840