DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and Cct4

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_877966.1	Gene:	Cct4 / 29374	RGDID:	727937	Length:	539	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	170/516 - (32%)
Similarity:	292/516 - (56%)	Gaps:	19/516 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGVDNPAAK 82
            :|....|.|:...|.|:.|.::::|||||||| ::..|:  |.|.:||||||||:.:.|.:|||:
  Rat    28 DKPAQIRFSNISAAKAVADAIRTSLGPKGMDK-MIQDGK--GDVTITNDGATILKQMQVLHPAAR 89

  Fly    83 ILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQD 147
            :||::|:.||.|.|||||||.::|..||....||:::.:||.||...:::|.:..||.||..::.
  Rat    90 MLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRP 154

  Fly   148 NSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRL-----KGSGELKSIQIIKKSGG 207
            ...||   |..|||.|.|:|:||::.|:....:.::|:|||::     ..|.:|:.|:|:||.||
  Rat   155 VQLSD---RETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGG 216

  Fly   208 TLGDSFLDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLAKIADLEMAEK 272
            |:.|..|.||.:|.:|.......|:|.|:|.:....:...|..: .:.|.|...|::..:...|:
  Rat   217 TIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDM-DNQIVVSDYAQMDRVLREER 280

  Fly   273 EKMKEKVDKILKHKCNVF-----INRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCTGGEIV 332
            ..:...|.:|.|..|||.     |.|..:.:.........::|.::..:.:.||.:....|.:.|
  Rat   281 AYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPV 345

  Fly   333 STFENPSLVKLGECDVIEQVMI-GEDTLLRFSG-VKLGEACTIVIRGATQQILDEADRSLHDALC 395
            :..:..:...||..::.|:|.: |...|.:.:| ...|:..|||:||:.:.:::||:||:|||||
  Rat   346 AHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDALC 410

  Fly   396 VLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYDSAQ 460
            |:...||:..:|.|||..|..:|..:.:.:....|.|:..:.|||.|:..:|:.:|:|||.:...
  Rat   411 VIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPIS 475

  Fly   461 LVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNII 521
            .|:|||..||||::|.|:::..|.::::.|..:.:...|....|..|:|....||::|:::
  Rat   476 TVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	170/516 (33%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	170/516 (33%)
Cct4	NP_877966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		170/516 (33%)
		TCP1_delta	25..538	CDD:239454	170/516 (33%)
		Cpn60_TCP1	44..539	CDD:278544	165/500 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820