DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and Cct6a

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001028856.1	Gene:	Cct6a / 288620	RGDID:	1304763	Length:	531	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	150/538 - (27%)
Similarity:	285/538 - (52%)	Gaps:	41/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILR 72
            |:.|..:|:..:|:.|...:...|..:.|::::.|||||..|:||:   .||.:::|.||..:|.
  Rat     4 VKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVS---GAGDIKLTKDGNVLLH 65

  Fly    73 AVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVA 137
            .:.:.:|.|.::..::..||:..||||||..::..|||::|:..:.:.|||:||..|:..|.:.|
  Rat    66 EMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKA 130

  Fly   138 LEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSGE---LKSI 199
            |:.|    :....|.|..|..|:::|||:|.:|:..:..|......||:::.::...|   |..:
  Rat   131 LQFL----EQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDEPIDLFMV 191

  Fly   200 QIIKKSGGTLGDSFLDEGFLLDKKPGVHQP---QRIENARILIANTPMDTDKIKVFGSSIKVDSL 261
            :|::....:..|:.|..|.:||.  |...|   :|:|||.||..|..::.:|.:| .|.....|.
  Rat   192 EIMEMKHKSETDTSLIRGLVLDH--GARHPDMKKRVENAYILTCNVSLEYEKTEV-NSGFFYKSA 253

  Fly   262 AKIADLEMAEKEKMKEKVDKILKHK---CN------VFINRQLIYNYPEQLFADARVMSIEHADF 317
            .:...|..||::.::::|.||::.|   |.      |.||::.|..:.....|...::::..|..
  Rat   254 EEREKLVKAERKFIEDRVKKIVELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKR 318

  Fly   318 DGIERLAYCTGGEIVSTFE--NPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEAC------TIV 374
            ..:|||....||..:::|:  ||..  ||...::.:..:||:   :|:.:   |.|      |::
  Rat   319 RNMERLTLACGGIALNSFDDLNPDC--LGHAGLVYEYTLGEE---KFTFI---EKCNNPRSVTLL 375

  Fly   375 IRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAF 439
            ::|..:..|.:...::.|.|..:...:.:..::.|.|..|..:|.|::|......|:..:.::||
  Rat   376 VKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAF 440

  Fly   440 ARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVL 504
            |.|||.:|..:|.|:|:|..:.:.:::|.|::..|.:|:|:..|:.....|:|:.:::.||:|:|
  Rat   441 ADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEMGVWDNYCVKKQLL 505

  Fly   505 MSASEAAEMILRVDNIIR 522
            .|.:..|..||.||.|:|
  Rat   506 HSCTVIATNILLVDEIMR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	150/538 (28%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	149/536 (28%)
Cct6a	NP_001028856.1	chap_CCT_zeta	3..530	CDD:274088	150/538 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810