DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and cct2

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_593017.1	Gene:	cct2 / 2542212	PomBaseID:	SPAC1D4.04	Length:	527	Species:	Schizosaccharomyces pombe

Alignment Length:	526	Identity:	327/526 - (62%)
Similarity:	423/526 - (80%)	Gaps:	2/526 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSLNPVRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDG 67
            |||||.::......:|:.|.||||||:||||:|||||||||||||||||  ...::|.:.|||||
pombe     1 MSLNPHQIFNESGIQERGENARLSSFVGAIAVGDLVKSTLGPKGMDKIL--QSNSSGDIVVTNDG 63

  Fly    68 ATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQ 132
            ||||:::.:||.|||:||::|:|||:|||||||||.|.|:||||:||.:|..|:|||:|:.|:|.
pombe    64 ATILKSIALDNAAAKVLVNISKVQDDEVGDGTTSVCVFAAELLRQAEIMVNAKIHPQVIIDGYRI 128

  Fly   133 ATQVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSGELK 197
            ||:.|::||.|::.||||...|||:||.||||||||||||.|:|:.||.||||||:|||||..|.
pombe   129 ATKTAIDALRASSIDNSSDPAKFRSDLENIARTTLSSKILSQNKNHFAQLAVDAVLRLKGSTNLD 193

  Fly   198 SIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLA 262
            :|||||..||.|.||||||||:|:|..||:.|:.:|||.||||||.|||||:||||:.::||:..
pombe   194 NIQIIKILGGKLDDSFLDEGFILNKTIGVNCPKVMENANILIANTAMDTDKVKVFGARVRVDTTG 258

  Fly   263 KIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCT 327
            |:|:||.||:||||.||:||..|..|.|||||||||:||||||||.:||||||||||||||:..|
pombe   259 KLAELERAEREKMKAKVEKIKSHNINCFINRQLIYNWPEQLFADAGIMSIEHADFDGIERLSLVT 323

  Fly   328 GGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQQILDEADRSLHD 392
            ||||.|||::|.|||||.|..||:::||||.:::||||:.|||||||:||||.|:|||::|::||
pombe   324 GGEIASTFDHPELVKLGHCKKIEEIIIGEDKMIKFSGVEAGEACTIVLRGATHQLLDESERAIHD 388

  Fly   393 ALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYD 457
            ||.||:.||.|||:..||||:|.|||.||.:.|...|||:|:|:.|||:||..|||.:|||||:|
pombe   389 ALAVLSQTVAESRVTLGGGCAEMLMAKAVEEAATHEPGKKAVAVSAFAKALSQLPTILADNAGFD 453

  Fly   458 SAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNIIR 522
            |::||::|:|.|..|..|:||||:.|::||:|..||.|:..:|:.|:.|.||.|:::||||.|::
pombe   454 SSELVAQLKAAHYDGNDTMGLDMDEGEIADMRAKGILEALKLKQAVVSSGSEGAQLLLRVDTILK 518

  Fly   523 CAPRRR 528
            .|||.|
pombe   519 AAPRPR 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	327/526 (62%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	320/516 (62%)
cct2	NP_593017.1	chap_CCT_beta	7..524	CDD:274082	321/518 (62%)
cct2	NP_593017.1	TCP1_beta	8..523	CDD:239452	320/516 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	596	1.000	Domainoid score	I28
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4696
Inparanoid	1	1.050	653	1.000	Inparanoid score	I126
OMA	1	1.010	-	-		QHG60896
OrthoFinder	1	1.000	-	-		FOG0004903
OrthoInspector	1	1.000	-	-		oto100586
orthoMCL	1	0.900	-	-		OOG6_101721
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1485
SonicParanoid	1	1.000	-	-		X3458
TreeFam	1	0.960	-	-
	14	13.860