DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT2 and cct7

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_775355.1	Gene:	cct7 / 192324	ZFINID:	ZDB-GENE-020419-7	Length:	547	Species:	Danio rerio

Alignment Length:	533	Identity:	190/533 - (35%)
Similarity:	300/533 - (56%)	Gaps:	12/533 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSLNPVRVLKNEAQEEKAEMARLSSFIGAI-AIGDLVKSTLGPKGMDKILVATGRNAGHVEVTND 66
            |...||.:|| |..:....:.:|.|.|.|. .:.:.|::||||:||||::|   .|.|...::||
Zfish     1 MMSTPVILLK-EGTDTSQGVPQLVSNINACQVVAEAVRTTLGPRGMDKLVV---DNRGKATISND 61

  Fly    67 GATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWR 131
            |||||:.:.|.:||||.|||::|.||.||||||||||:||:|.|::.:..||:.||||.|:..:|
Zfish    62 GATILKLLDVVHPAAKTLVDIARSQDAEVGDGTTSVTLLAAEFLKQLKPYVEEGLHPQTIIRAFR 126

  Fly   132 QATQVALEALTAAAQDNSSSDEKFRNDLL-NIARTTLSSKILHQHKDFFANLAVDAVMRLKGSGE 195
            .|||:|::.:...|......|::.:..|| ..|.|.|:||::...||||:.:.|||||.|.....
Zfish   127 IATQLAVKKIKEIAVTIKKDDKQEQRRLLEKCAATALNSKLIAGQKDFFSKMVVDAVMMLDDLLP 191

  Fly   196 LKSIQIIKKSGGTLGDSFLDEGFLLDKK---PGVH-QPQRIENARILIANTPMDTDKIKVFGSSI 256
            ||.|.:.|..||.|.:|.|..|....|.   .|.. ||:|..|.:|.:.|..::. |.:...:.:
Zfish   192 LKMIGVKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKRYMNPKIALLNIELEL-KAEKDNAEV 255

  Fly   257 KVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIE 321
            :|:|:.....:..||...:.:|::||.|....|.:::..|.:...|.||...:........:.::
Zfish   256 RVNSMEDYQAIVDAEWNILYDKLEKIHKSGAKVVLSKLPIGDVATQYFAYRNLFCAARVVEENLK 320

  Fly   322 RLAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQQILDEA 386
            |.....||.|.::..:.:...||:|::.|:|.:|.:....|.|....:.|||::||..:|.::|.
Zfish   321 RTMMACGGSIQTSVGSLTDDVLGQCELFEEVQVGGERYNFFKGCPKAKTCTIILRGGAEQFMEET 385

  Fly   387 DRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIA 451
            |||||||:.::...:|...|:.|||..|..::..:...:...|||:.:.|.|:|:||..:|..:.
Zfish   386 DRSLHDAIMIVRRAIKNDSIVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLC 450

  Fly   452 DNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILR 516
            ||||:|:..::::|||.||||....|:|:....:||..:..:.|...|:...|.:|||||.:||.
Zfish   451 DNAGFDATNILNKLRAKHAQGGMWYGVDVNNEDIADNFQACVWEPSIVRINALTAASEAACLILS 515

  Fly   517 VDNIIRCAPRRRV 529
            ||..|: .||..|
Zfish   516 VDETIK-NPRSSV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	190/533 (36%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	185/522 (35%)
cct7	NP_775355.1	chap_CCT_eta	4..525	CDD:274086	187/526 (36%)
cct7	NP_775355.1	TCP1_eta	5..525	CDD:239456	187/525 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830