DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and Cct7

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_031664.3	Gene:	Cct7 / 12468	MGIID:	107184	Length:	544	Species:	Mus musculus

Alignment Length:	547	Identity:	198/547 - (36%)
Similarity:	303/547 - (55%)	Gaps:	28/547 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSLNPVRVLKNEAQEEKAEMARLSSFIGAI-AIGDLVKSTLGPKGMDKILVATGRNAGHVEVTND 66
            |...||.:|| |..:....:.:|.|.|.|. .|.:.|::||||:||||::| .||  |...::||
Mouse     1 MMPTPVILLK-EGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIV-DGR--GKATISND 61

  Fly    67 GATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWR 131
            |||||:.:.|.:||||.|||:::.||.||||||||||:||:|.|::.:..||:.||||||:..:|
Mouse    62 GATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126

  Fly   132 QATQVALE-----ALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLK 191
            .|||:|:.     |:|...||....    |..|...|.|.||||::.|.|.|||.:.|||||.|.
Mouse   127 TATQLAVNKIKEIAVTVKKQDKVEQ----RKMLEKCAMTALSSKLISQQKVFFAKMVVDAVMMLD 187

  Fly   192 GSGELKSIQIIKKSGGTLGDSFLDEGFLLDKK---PGVH-QPQRIENARILIANTPMDTDKIKVF 252
            ...:||.|.|.|..||.|.:|.|..|....|.   .|.. ||::.:|.:|.:.|..::. |.:..
Mouse   188 ELLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELEL-KAEKD 251

  Fly   253 GSSIKVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADF 317
            .:.|:|.::.....:..||...:.:|::||.:....|.:::..|.:...|.|||..:........
Mouse   252 NAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPE 316

  Fly   318 DGIERLAYCTGGEIVSTFENPSLVK--LGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQ 380
            :.::|.....||.|.::..  :||.  ||.|.|.|:..||.:....|:|....:.|||::||..:
Mouse   317 EDLKRTMMACGGSIQTSVN--ALVPDVLGHCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAE 379

  Fly   381 QILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLS 445
            |.::|.:||||||:.::...:|...::.|||..|..::..:...:...|||:.:.|.|:|:||..
Mouse   380 QFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEI 444

  Fly   446 LPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEA 510
            :|..:.||||:|:..::::|||.||||....|:|:....:||..:..:.|...|:...|.:||||
Mouse   445 IPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNENIADNFQAFVWEPAMVRINALTAASEA 509

  Fly   511 AEMILRVDNIIRCAPRRRV----PDRG 533
            |.:|:.||..|: .||..|    |..|
Mouse   510 ACLIVSVDETIK-NPRSTVDPPAPSAG 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	196/542 (36%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	191/528 (36%)
Cct7	NP_031664.3	chap_CCT_eta	3..525	CDD:274086	193/533 (36%)
		TCP1_eta	5..525	CDD:239456	193/531 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..544		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820