DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT2 and Cct5

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_031663.1	Gene:	Cct5 / 12465	MGIID:	107185	Length:	541	Species:	Mus musculus

Alignment Length:	526	Identity:	174/526 - (33%)
Similarity:	294/526 - (55%)	Gaps:	19/526 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PVRVLKNEAQEEKAEMARL----SSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDG 67
            |..::|:  |:.|:.:..|    |..:.|.|:.:.::::|||.|:||::|   ...|.|.:||||
Mouse    15 PFLIIKD--QDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMV---DKDGDVTITNDG 74

  Fly    68 ATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQ 132
            ||||..:.||:..||::|::|:.||:|:|||||.|.|||..||.|||:|:::.:||..|..|:.|
Mouse    75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQ 139

  Fly   133 ATQVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRL----KGS 193
            |.::|::.|...: |....|......|:..|:|||.||:::......|.:||:||:.:    :..
Mouse   140 AARIAIQHLDKIS-DKVLVDINNPEPLIQTAKTTLGSKVINSCHRQMAEIAVNAVLTVADMERRD 203

  Fly   194 GELKSIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQ-PQRIENARILIANTPMDTDKIKVFGSSIK 257
            .:.:.|::..|.||.|.|:.|.:|.::||.....| |:::.:|:|.|...|.:..|.|. ...:.
Mouse   204 VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVVDAKIAILTCPFEPPKPKT-KHKLD 267

  Fly   258 VDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIER 322
            |.|:.....|:..||||.:|.:.:|.:...|:.|.:....:....|.....:.::.......||.
Mouse   268 VMSVEDYKALQKYEKEKFEEMIKQIKETGANLAICQWGFDDEANHLLLQNGLPAVRWVGGPEIEL 332

  Fly   323 LAYCTGGEIVSTFENPSLVKLGECDVIEQVMIG--EDTLLRFSGVKLGEACTIVIRGATQQILDE 385
            :|..|||.||..|...:..|||...|::::..|  :|.:|.....|...|.||.|||..:.|::|
Mouse   333 IAIATGGRIVPRFSELTSEKLGFAGVVQEISFGTTKDKMLVIEKCKNSRAVTIFIRGGNKMIIEE 397

  Fly   386 ADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAI 450
            |.|||||||||:...::::|:::|||.:|...|.||.::|.:.|..|..|:.|||.||..:|.|:
Mouse   398 AKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMAL 462

  Fly   451 ADNAGYDSAQLVSELRAGHA-QGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMI 514
            ::|:|.:..|.::|:||... :....||:|.......|::...:.|:...|:|.:..|::...||
Mouse   463 SENSGMNPIQTMTEVRARQVKESNPALGIDCLHKGSNDMQYQHVIETLIGKKQQISLATQMVRMI 527

  Fly   515 LRVDNI 520
            |::|:|
Mouse   528 LKIDDI 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	174/526 (33%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	173/523 (33%)
Cct5	NP_031663.1	TCP1_epsilon	10..535	CDD:239455	174/526 (33%)
Cct5	NP_031663.1	Cpn60_TCP1	44..533	CDD:278544	165/493 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820